全文获取类型
收费全文 | 1608篇 |
免费 | 179篇 |
国内免费 | 3篇 |
专业分类
电工技术 | 14篇 |
综合类 | 1篇 |
化学工业 | 528篇 |
金属工艺 | 42篇 |
机械仪表 | 44篇 |
建筑科学 | 36篇 |
矿业工程 | 4篇 |
能源动力 | 67篇 |
轻工业 | 323篇 |
水利工程 | 5篇 |
石油天然气 | 7篇 |
无线电 | 150篇 |
一般工业技术 | 292篇 |
冶金工业 | 33篇 |
原子能技术 | 13篇 |
自动化技术 | 231篇 |
出版年
2023年 | 15篇 |
2022年 | 19篇 |
2021年 | 93篇 |
2020年 | 58篇 |
2019年 | 59篇 |
2018年 | 91篇 |
2017年 | 101篇 |
2016年 | 100篇 |
2015年 | 70篇 |
2014年 | 101篇 |
2013年 | 129篇 |
2012年 | 114篇 |
2011年 | 118篇 |
2010年 | 94篇 |
2009年 | 95篇 |
2008年 | 59篇 |
2007年 | 62篇 |
2006年 | 43篇 |
2005年 | 44篇 |
2004年 | 23篇 |
2003年 | 32篇 |
2002年 | 29篇 |
2001年 | 27篇 |
2000年 | 11篇 |
1999年 | 17篇 |
1998年 | 21篇 |
1997年 | 14篇 |
1996年 | 12篇 |
1995年 | 9篇 |
1994年 | 8篇 |
1993年 | 4篇 |
1992年 | 6篇 |
1991年 | 7篇 |
1990年 | 5篇 |
1989年 | 3篇 |
1987年 | 8篇 |
1986年 | 4篇 |
1985年 | 12篇 |
1984年 | 8篇 |
1983年 | 9篇 |
1982年 | 3篇 |
1981年 | 3篇 |
1980年 | 6篇 |
1979年 | 9篇 |
1978年 | 4篇 |
1974年 | 2篇 |
1971年 | 4篇 |
1959年 | 2篇 |
1933年 | 2篇 |
1916年 | 2篇 |
排序方式: 共有1790条查询结果,搜索用时 15 毫秒
1.
Ji Hye Yang Sae Kwang Ku IL Je Cho Je Hyeon Lee Chang-Su Na Sung Hwan Ki 《International journal of molecular sciences》2021,22(4)
Hepatic fibrosis occurs when liver tissue becomes scarred from repetitive liver injury and inflammatory responses; it can progress to cirrhosis and eventually to hepatocellular carcinoma. Previously, we reported that neoagarooligosaccharides (NAOs), produced by the hydrolysis of agar by β-agarases, have hepatoprotective effects against acetaminophen overdose-induced acute liver injury. However, the effect of NAOs on chronic liver injury, including hepatic fibrosis, has not yet been elucidated. Therefore, we examined whether NAOs protect against fibrogenesis in vitro and in vivo. NAOs ameliorated PAI-1, α-SMA, CTGF and fibronectin protein expression and decreased mRNA levels of fibrogenic genes in TGF-β-treated LX-2 cells. Furthermore, downstream of TGF-β, the Smad signaling pathway was inhibited by NAOs in LX-2 cells. Treatment with NAOs diminished the severity of hepatic injury, as evidenced by reduction in serum alanine aminotransferase and aspartate aminotransferase levels, in carbon tetrachloride (CCl4)-induced liver fibrosis mouse models. Moreover, NAOs markedly blocked histopathological changes and collagen accumulation, as shown by H&E and Sirius red staining, respectively. Finally, NAOs antagonized the CCl4-induced upregulation of the protein and mRNA levels of fibrogenic genes in the liver. In conclusion, our findings suggest that NAOs may be a promising candidate for the prevention and treatment of chronic liver injury via inhibition of the TGF-β/Smad signaling pathway. 相似文献
2.
3.
Photonic Network Communications - Optical packet switching is a prominent technology proposing not only a reduction in the energy consumption by the elimination of numerous... 相似文献
4.
Vitamin D Compounds PRI-2191 and PRI-2205 Enhance Anastrozole Activity in Human Breast Cancer Models
Beata Filip-Psurska Mateusz Psurski Artur Anisiewicz Patrycja Libako Ewa Zbrojewicz Magdalena Maciejewska Micha Chodyski Andrzej Kutner Joanna Wietrzyk 《International journal of molecular sciences》2021,22(5)
1,25-Dihydroxycholecalciferol, the hormonally active vitamin D3 metabolite, is known to exhibit therapeutic effects against breast cancer, mainly by lowering the expression of estrogen receptors and aromatase activity. Previously, the safety of the vitamin D active metabolite (24R)-1,24-dihydroxycholecalciferol (PRI-2191) and 1,25(OH)2D3 analog PRI-2205 was tested, and the in vitro activity of these analogs against different cancer cell lines was studied. We determined the effect of the two vitamin D compounds on anastrozole (An) activity against breast cancer based on antiproliferative activity, ELISA, flow cytometry, enzyme inhibition potency, PCR, and xenograft study. Both the vitamin D active metabolite and synthetic analog regulated the growth of not only estrogen receptor-positive cells (T47D and MCF-7, in vitro and in vivo), but also hormone-independent cancer cells such as SKBR-3 (HER-2-positive) and MDA-MB-231 (triple-negative), despite their relatively low VDR expression. Combined with An, PRI-2191 and PRI-2205 significantly inhibited the tumor growth of MCF-7 cells. Potentiation of the antitumor activity in combined treatment of MCF-7 tumor-bearing mice is related to the reduced activity of aromatase by both An (enzyme inhibition) and vitamin D compounds (switched off/decreased aromatase gene expression, decreased expression of other genes related to estrogen signaling) and by regulation of the expression of the estrogen receptor ERα and VDR. 相似文献
5.
Lydia Saidi Dr. Djenisa H. A. Rocha Dr. Oualid Talhi Dr. Yamina Bentarzi Prof. Dr. Bellara Nedjar-Kolli Dr. Khaldoun Bachari Dr. Filipe A. Almeida Paz Dr. Luisa A. Helguero Prof. Dr. Artur M. S. Silva 《ChemMedChem》2019,14(10):1041-1048
Breast and prostate cancers are frequently treated with chemotherapy. Several novel chemicals are being reported for this purpose, particularly synthetic and natural benzophenones. This work reports the synthesis of substituted 2-hydroxybenzophenones through 1,4-conjugate addition/intramolecular cycloaddition/dehydration of nitromethane on key intermediate chromones. Structures were extensively studied by means of 2D NMR spectroscopy and single-crystal XRD. Their cytotoxicity was evaluated in vitro in two breast cancer cell lines (MDA-MB-231 and T47-D) and one prostate cancer cell line (PC3). The most potent compound exhibited good cytotoxic effects against the three cancer cell lines (IC50 values ranging from 12.09 to 26.49 μm ) and induced cell-cycle retardation only on prostate cancer cells, which suggested that it might exert cell-type-specific effects. 相似文献
6.
7.
Yi‐Hung Chen Ching‐Yuan Chang Wei‐Ling Su Chun‐Yu Chiu Yue‐Hwa Yu Pen‐Chi Chiang Chiung‐Fen Chang Je‐Lueng Shie Chyow‐San Chiou Sally IM Chiang 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2005,80(1):68-75
This study investigates the ozonation of CI Reactive Black 5 (RB5) by using the rotating packed bed (RPB) and completely stirred tank reactor (CSTR) as ozone contactors. The RPB, which provides high gravitational force by adjusting the rotational speed, was employed as a novel ozone contactor. The same ozone dosage was separately introduced into either the RPB or the CSTR for the investigation, while the experimental solution was continuously circulated within the apparatus consisting of the RPB and CSTR. The decolorization and mineralization efficiencies of RB5 in the course of ozonation are compared for these two methods. Moreover, the dissolved and off‐gas ozone concentrations were simultaneously monitored for the further analysis. As a result, the ozone mass transfer rate per unit volume of the RPB was significantly higher because of its higher mass transfer coefficient and gas–liquid concentration driving force. Furthermore, ozonation kinetics was found to be independent of the gravitational magnitude of an ozone gas–liquid contactor. Therefore, the results suggest employing RPBs as ozone‐contacting devices with the advantage of volume reduction. The experimental results, which can be used for further modeling of the ozonation process in the RPB, also show the requirement of correct design for the RPB. Consequently, the present study is useful for the understanding of practical application of RPBs. Copyright © 2004 Society of Chemical Industry 相似文献
8.
Further evidence was delivered that certain impurities, which could be contained in MgO samples, might be responsible for observed variability in MgO basicity and catalytic performance in oxidative coupling of methane. The surface basicity/base strength distribution of a series of MgO samples containing or not containing Ca and Na impurities was determined by a temperature-programmed desorption of CO2. It was revealed that samples containing Ca and Na impurities have much more medium, strong and very strong basic sites. The surface basicity of MgO samples containing added alkali or alkaline earth compounds or water was characterized by a test reaction of transformation of 2-butanol. It was confirmed that the introduction of these compounds to a pure MgO enhanced both its basicity and activity in oxidative coupling of methane. 相似文献
9.
10.