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A sensitive liquid chromatography-electrospray ionization-tandem mass spectrometric(LC-MS/MS) method for the determination of CPRC-127 in human plasma was developed and validated. The plasma was extracted using a liquid-liquid phase extraction(LLE), and the sample extract was injected onto the LC-MS/MS system. The limit of quantitation(LLOQ) for CPRC-127 is 0.5 μg•L-1. This method allows the reproducible and accurate quantification with the concentration range of 0.5-1 000 μg•L-1. This method can be applied to the quantitation of CPRC-127 in human plasma. 相似文献
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A sensitive liquid chromatography-electrospray ionization-tandem mass spectrometric(LC-MS/MS) method for determination of compound 8601, 8602, 8603 in plasma was developed. The plasma compound 8601, 8602, 8603 was extracted using a solid phase extraction(SPE), and the sample extract was injected onto the LC-MS/MS system. The limit of quantitation(LLOQ) for compound 8601, 8602, 8603 is 0.500 μg•L-1. This method can be applied to the quantitation compound 8601, 8602, 8603 in plasma. 相似文献
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A sensitive liquid chromatography-electrospray ionization-tandem mass spectrometric(LC-MS/MS) method for the simultaneous determination of TF and its metabolites M1 and M2 in human plasma were developed and validated. The plasma TF, M1, M2 were extracted using a solid phase extraction(SPE), and the sample extract was injected onto the LC-MS/MS system. The limits of quantitation(LLOQ) for TF, M1, M2 are 1 ng•L-1. This method allowes the reproducible and accurate quantification with the concentration range of 1-500 ng•L-1. This method can be applied to the quantitation of TF, M1, M2 in human plasma. 相似文献
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