New Visions for Old Cities: The Role of Visioning in Planning

Many plans and strategies these days are underpinned by ‘visions’. This article examines the cultural and policy shift in planning in the UK toward more integrated and participative practice, and the potential role of visioning in this new climate. Reviewing examples of vision planning in the US, where the process has a longer lineage, it argues that these interventions suffer from a lack of evaluation of the effects of ‘visioning’. Yet this visioning approach has been adopted in certain cities and towns in Northern Ireland in recent years. This article assesses the impact of this approach in a detailed case study and finds the impact to have been modest.     

Addressing the information gaps associated with valuing green infrastructure in west Michigan: INtegrated Valuation of Ecosystem Services Tool (INVEST)

Land use change is profoundly influencing the environmental resources of the Great Lakes region. In West Michigan, population growth and rapid land use change have resulted in urbanization and a loss in the diversity of green infrastructure that provides a variety of benefits–ecosystem services–to regional residents and visitors. To address these changes in land use and cover in ways that are objective, transparent, and defensible, local policy makers need tools to help inform local and regional land use decisions. An interdisciplinary team, engaged by a regional policy organization, developed one such online tool, the INtegrated Valuation of Ecosystem Services Tool (INVEST). INVEST utilizes static GIS maps, graphs, and tables, to help educate local and regional decision-makers about the underlying values of ecosystem services associated with green infrastructure, particularly those services that do not pass through traditional commercial markets. In this article we provide a general overview of the development of INVEST and examine its current application as an educational tool, including the specific challenges associated with addressing the information gaps.     

A relationship between proteinase activity and clinical parameters in the treatment of periodontal disease

The objective of this research was to determine the effectiveness of a biochemical assay which measures proteolytic enzyme activity in gingival crevicular fluid (GCF) and to relate this enzyme activity to clinical parameters traditionally utilized for periodontitis detection. A clinical trial was conducted on 8 periodontitis subjects with > or =4 sites exhibiting a loss of attachment of > or =5 mm and probing depths of > or =5 mm with bleeding on probing. On each subject, a plaque index was performed, followed by GCF sampling at those sites which exhibited a loss of attachment and probing depths. GCF was analyzed for activity against benzoyl-L-arginine-p-nitroanilide in the presence (BAPNA w/gly-gly) and the absence (BAPNA w/o gly-gly) of glycyl-glycine and against MeOSuc-Ala-Ala-Pro-Val-pNA and Suc-Ala-Ala-Pro-Phe-pNA for neutrophil serine proteinases activity (elastase and cathepsin G, respectively). Subsequently, a gingival index was performed, attachment levels and probing depths were recorded using a constant force probe with bleeding on probing being noted. A split-mouth design was employed and half mouths were randomly assigned to the following treatment groups: group A, half of the mouth received scaling/root planing and polishing: group B, half of the mouth received no treatment (control). Subjects were treated, then instructed on toothbrushing and interdental cleaning. After 4 weeks, subjects returned to receive a plaque index; GCF sampling, gingival index, attachment levels, probing depths and bleeding on probing as described above. Using a paired Student t-test, the findings suggest that BAPNA w/gly-gly was significantly less in treatment sites than in non-treated control sites (p=0.05). No such correlation was found for other activities, including neutrophil serine proteinases which were shown to occur in GCF in free, proteolytically active forms. In addition, significant treatment effects were detected for probing depths (p= 0.03) which reduced by 1.3 mm and attachment levels (p=0.02) which gained 0.7 mm. The reduction of P. gingivalis from treated periodontitis sites as detected by a significant decrease in BAPNA w/ gly-gly may prove to be a valuable marker for periodontal disease activity.     

The effect varied scanning electron microscopy desiccation techniques has on demineralized dentin

The study objective was to assess (a) the effect of a rubbing‐application of ethylenediaminetetraacetic acid (EDTA) or citric acid (CA) has on the ultrastructure of surface dentin and (b) the effect of two scanning electron microscopy (SEM) desiccation preparation techniques have on the collagen surface produced. Treatment regions on proximal root surfaces of extracted human teeth were root planned to expose dentin. Cotton pellets soaked in either 30% CA or 24% EDTA solution were rubbed on the treatment region then processed for SEM using one of two desiccation techniques, that is, (a) critically point dried from liquid CO₂ (control) or (b) air‐dried from tetramethylsilane (experimental). Specimens were coated with gold/palladium and viewed/photographed with an SEM. Specimens of the control groups displayed tufted fibrils (CA > EDTA) with many dentin tubules being partially obscured by overhanging fibrils. Air‐dried specimens of both treatment groups displayed a flat intact monolayer devoid of a matted meshwork of fibrous collagen. Discrete fibril “sprigs,” emanating from the surface monolayer, were characteristic of the EDTA group only. The rubbing‐application of EDTA on dentin produces a tufted fibril surface somewhat similar to that produced by CA. Air‐drying desiccation of both resulted in marked distortion with fibril collapse/coalescence of the tufted collagen matrix.     

Protein adsorption characteristics of plasma treated polyurethane surfaces

The effect of various plasma surface treatments on the protein adsorption characteristics of two polyurethane elastomers (Acushnet E417-0 [ACx] and Texin 480 AR [TN]) were studied. Both substrates are based upon diphenylmethane 4,4-diisocyanate (MDI) hard segments and polyester soft segments. Adsorption characteristics of the untreated samples were initially established, followed by plasma treated surfaces. Contact angle and 2 h albumin adsorption were determined. (1) Results of this study indicate that the protein adsorption characteristics of crosslinked substrate ACx is more linear than that of non-crosslinked substrate TN. Further, substrate TN adsorbs seven-fold greater protein at a rate four times higher on its surface than ACx.N,N-Ethylene bis (stearamide), a processing aid used in substrate TN, may encourage greater protein adsorption on substrate TN and variation in the soft segment mobility between the substrates also may affect their adsorption characteristics. (2) Plasma treatments using CH₄ and/or C _x F _y chemistries increased the contact angle for both substrates while those with O₂ and O₂/CF₄ decreased the contact angle for the substrates considered. In general, the contact angle of the substrates exhibiting greater protein adsorption was smaller.     

Design and Application of Static Logic Directors

A digital computer program written by Westinghouse engineers aids the design of new static logic systems for metal mills. The computer program accepts logic equations specifying the functions to be performed. The program generates circuit drawings of logic circuitry plus paper tape for controlling an automatic wiring machine. The automatic wiring machine wires the back panel receptacles for plug-in cards which contain the integrated-circuit AND/NAND logic elements. The design engineer determines functional requirements to be performed by the logic circuits. He expresses these requirements in convenient logic statement form and adds comments on circuit functioning. Logic and comment statements are keypunched for input to the computer. The computer analyzes the equations, converts the functions to AND/ NAND logic circuits and generates the punched-paper tape required by the automatic wiring machine. In addition, the computer generates the circuit diagrams showing the actual AND/NAND circuits with complete (JIC) cross references and comments on circuit functioning. During computer processing diagnostic messages are generated to aid in finding design errors. Only one type of logic board is used in the new static logic system to perform all logic functions. This reduces maintenance to mere board replacement and greatly reduces spare board inventory. Triac outputs are featured in addition to normal contact closure outputs. Traic is a static ac switch which can operate pilot-operated solenoid valves, contactors, indicating lights, and other common ac loads. The logic system combines the advantages of fully wired integrated-circuit logic with the convenience and accuracy of computer aided design.     

Nested Algorithms and ``The Original Imitation Game Test': A Reply to James Moor

Minds and Machines -     

The all particle Monte Carlo method: 1990 status report

Development of the All Particle Method, a project to simulate the transport of particles via the Monte Carlo method, has proceeded on two fronts: data collection and algorithm development. In this paper we report on the status of both these aspects. The data collection is nearly complete with the addition of electron and atomic data libraries and a newly revised photon library to the existing neutron and charged particle libraries. We describe the basic organization of the Monte Carlo computer code that will actually perform the simulation. Algorithm development has proceeded less quickly than the data portion of the project. The new Response Matrix Monte Carlo method is summarized and some numerical results presented.     

The effects of ultrasound and light on indocyanine-green-treated tumour cells and tissues

Photodynamic therapy (PDT) is emerging as a treatment modality for the management of neoplastic disease. Despite considerable clinical success, its application for the treatment of deep‐seated lesions is constrained by the inability of visible light to penetrate deeply into tissues. An emerging alternative approach exploits the fact that many photosensitisers respond to ultrasound, eliciting cytotoxic effects on target cells and tissues; this has become known as sonodynamic therapy (SDT). The objectives of this study were 1) to determine whether the IR‐absorbing dye, indocyanine green (ICG), can be employed as a sonosensitiser and 2) to determine whether ultrasound can be used to enhance ICG‐mediated PDT. Exposing ICG‐treated mouse fibrosarcoma cells to ultrasound at an energy density of 30 J cm^?2 decreased cell viability by 65 %. Prior exposure of ICG‐treated cells to light (λ 830 nm) and subsequent treatment with ultrasound led to a 90 % decrease in cell viability. In combination treatments a synergistic effect was observed at lower doses of ultrasound. Microscopic examination of cell populations treated with light or ultrasound demonstrated the production of intracellular reactive oxygen species (ROS). Using a mouse tumour model, treatment with light, ultrasound, or a combination thereof led to respective decreases in tumour growth of 42, 67, and 98 % at day 27 post‐treatment. These results could provide a means of circumventing light‐penetration issues that currently challenge the widespread use of PDT in the treatment of cancer.     

Effect of machining on fracture toughness of corundum

Different machining processes such as ultrasonic machining and grinding by a diamond wheel produce varying degrees of surface damage. The amount of surface damage appeared to be related to the type of machining process. However, the degree of surface damage could not be related to the surface roughness for different machining processes. The surface damage created by the machining process can be fully or partially recovered by heat treatment subsequent to machining. The degree of recovery by heat treatment seems to be dependent on the severity of the surface damage during the machining process. Observation of the surface microcracks and determination of the fracture toughness of the material after machining or heat treatment indicated recovery of some of the microcracks during the heat treatment.