《有机化学》新形态教材建设

以新形态出版的《有机化学》(第3版)教材,起步于国家优秀教材,该教材连续入选“十一·五”“十二·五”国家级规划教材。在第3版教材的建设过程中,编者通过精选纸版教材内容,满足多专业课程教学的需要;通过建设适合移动端、网络端的线上教学资源,适应新时代一流课程建设需要。纸版教材与媒体资源的融合创新,顺应一流本科课程建设和目标导向的创新人才培养要求,为使用者提供了个性化学习平台,有助于其获得“成长为有机化学家所需的知识、能力和价值观”。     

催化加氢制备1,2-二(邻氨基苯氧基)乙烷

本文介绍了以Pd/C作催化剂,1,2-二(邻硝基苯氧基)乙烷催化加氢制备1,2-二(邻氨基苯氧基)乙烷的方法,对影响反应的主要因素进行了考察,通过正交试验确定优化条件。小试产品收率接近90%,纯度99.6%。     

基于工程训练教学培养大学生创新能力的探索与实践

工程训练实践教学对培养大学的工程综合能力、工程素质和创新能力发挥着重要的作用。以培养大学生工程创新能力为目标,分析现行工程训练创新实践教学过程中存在的问题,剖析产生问题的原因,提出若干解决措施,对提高学生创新能力,培养高素质应用型人才具有促进作用。     

3,5-二氯苯胺合成4,5,7-三氯喹啉

4，5，7-三氯喹啉是一种能够迅速杀灭人体疟原虫的有效抗疟药，并可以与多种取代苯酚缩合制成杀菌剂、除草剂。介绍了以3，5-二氯苯胺、原甲酸三乙酯和氰乙酸乙酯为原料，经过缩合、成环、水解和氯代4步反应制备4，5，7-三氯喹啉的方法，对相关的试验条件进行了考察，通过红外光谱、核磁共振谱和液相色谱对4，5，7-三氯喹啉的结构和纯度进行表征和测定，试验结果为4，5，7-三氯喹啉的纯度大于96％，总收率达到53％。     

Synthesis and Tribological Behaviour of 1,3,4-Thiadiazole Schiff Base Derivatives as Multifunctional Lubricant Additives

Six new 1,3,4-thiadiazole Schiff base derivatives were synthesized and characterized by IR spectroscopy and ~1H NMR spectrometry, and their anti-corrosion properties and thermal stability were investigated via thermogravimetric analysis(TGA) and copper strip corrosion test. The tribological behavior of the said Schiff base derivatives was evaluated on an Optimol SRV~?4 oscillating reciprocating friction and wear tester. The worn surfaces of the steel discs were investigated using a scanning electron microscope(SEM) and energy dispersive X-ray spectrometer(EDS). The test results indicated that these thiadiazole Schiff base derivatives possessed favourable thermal stability, corrosion inhibiting ability and the capability of improving the tribological characteristic of the base oil effectively. It is assumed that the adsorbed additives probably reacted with the steel surfaces during the friction process, resulting in the formation of a protective film composed of sulphates, sulphides and organic nitrogen compounds.     

Pd/C催化剂选择加氢合成4,4’-二氨基二苯乙烯-2,2’-二磺酸

在水介质中,采用Pd/C-OVN复合催化剂,研究了4,4’-二硝基二苯乙烯-2,2’-二磺酸(DNS)选择加氢合成4,4’-二氨基二苯乙烯-2,2’-二磺酸。用正交设计法对工艺条件进行优化,得出最佳反应条件为:原料DNS质量浓度200 g/L,Pd/C催化剂用量2.0％,助催化剂OVN用量0.8％,反应温度65℃。在此条件下考察了催化剂的稳定性,产物结构经红外光谱确证。     

催化加氢法制备4,4′-二氨基二苯乙烯-2,2′-二磺酸

INTRODUCTION 4,4′-Diaminostilbene-2,2′-disulfonic acid(DAS) is an important intermediate which is widely used in synthesis of fluorescent whitening agents, direct dyes and reactive dyes[1,2].So far, the conventional procedure using Fe as catalyst for the production of DAS in China is greatly limited, due to industrial waste water, high labor intensity and low production capability. The electrochemical reduction method has been reported[3] overseas, but it is not suitable for China considering its large equipment investment, lower yield and great power consumption. Compared with the methods mentioned above, the catalytic hydrogenation method has attracted a great deal of attention in view of its simple and easy operation, high production capacity and high production efficiency[4-6].The relatively cheap Raney nickel is not used here since it shows a low safety performance in preparing DAS at a high reaction temperature and high pressure. In this paper, highly reactive and recyclable palladium-carbon is chosen as the catalyst. DAS of high purity and high yield is prepared under mild conditions. The catalytic hydrogenation method is a prospective method in producing DAS.     

3,5-二甲基苯甲酰胺的制备

以均三甲苯为原料，用稀硝酸回流氧化为3，5-二甲基苯甲酸；再由二氯亚砜氯化之后与氨水在低温下反应制得3，5-二甲基苯甲酰胺，产品总收率38.3%，熔点131℃-133℃。给出了中间产物3，5-二甲基苯甲酸及3，5二甲基苯甲酰胺的红外光谱数据。     

PREPARATION OF 4,4′-DIAMINOSTILBENE-2,2′-DISULFONIC ACID BY CATALYTIC HYDROGENATION

INTRODUCTION4 ,4′ Diaminostilbene 2 ,2′ disulfonicacid (DAS)isanimportantintermediatewhichiswidelyusedinsynthesisoffluorescentwhiteningagents ,directdyesandreactivedyes[1,2 ] .Sofar ,theconventionalprocedureusingFeascatalystfortheproductionofDASinChinai…     

2,3,5,6-四氟苯胺的合成

以2,3,5,6-四氟苯甲酸为原料,经过酰氯制得酰胺后,再经霍夫曼降解制得2,3,5,6-四氟苯胺,总收率76.5%,产品含量98%,是一条有望工业化的合成路线。