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排序方式: 共有644条查询结果,搜索用时 15 毫秒
1.
Cheraghi Alireza Yoozbashizadeh Hossein Ringdalen Eli Safarian Jafar 《Metallurgical and Materials Transactions B》2019,50(4):1566-1580
Metallurgical and Materials Transactions B - The calcination and the reduction behaviors of a low-grade manganese ore by methane was studied at 973 K to 1273 K by several techniques. The onset... 相似文献
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Functional Chromatography Reveals Three Natural Products that Target the Same Protein with Distinct Mechanisms of Action 下载免费PDF全文
Dr. Min Jin Kang Dr. Tongde Wu Dr. E. M. Kithsiri Wijeratne Eric C. Lau Damian J. Mason Celestina Mesa Joseph Tillotson Prof. Dr. Donna D. Zhang Prof. Dr. A. A. Leslie Gunatilaka Dr. James J. La Clair Prof. Dr. Eli Chapman 《Chembiochem : a European journal of chemical biology》2014,15(14):2125-2131
Access to lead compounds with defined molecular targets continues to be a barrier to the translation of natural product resources. As a solution, we developed a system that uses discrete, recombinant proteins as the vehicles for natural product isolation. Here, we describe the use of this functional chromatographic method to identify natural products that bind to the AAA+ chaperone, p97, a promising cancer target. Application of this method to a panel of fungal and plant extracts identified rheoemodin, 1‐hydroxydehydroherbarin, and phomapyrrolidone A as distinct p97 modulators. Excitingly, each of these molecules displayed a unique mechanism of p97 modulation. This discovery provides strong support for the application of functional chromatography to the discovery of protein modulators that would likely escape traditional high‐throughput or phenotypic screening platforms. 相似文献
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Synthesis of Gemini‐Like Methyl Acrylate‐Acrylic Acid‐Methyl Acrylate Triblock Copolymers Surfactants by RAFT Polymerization in Solution and Investigation of their Behavior at the Air–Water Interface 下载免费PDF全文
Erlei Yu Letao Zhang Yagang Zhang Zeyu Liu Tinggui Wang Xuanchi Liu Wumanjiang Eli 《Journal of surfactants and detergents》2015,18(5):729-738
A series of methyl acrylate‐acrylic acid amphiphilic triblock copolymers (PMA‐PAA‐PMA) were prepared by solution polymerization using S,S′‐bis (α,α‐dimethy1acetic acid) trithiocarbonate (BDAT) as a reversible addition fragmentation chain transfer (RAFT) agent and methyl acrylate (MA) as the first monomer. The triblock copolymers and their common MA homopolymer precursors were characterized in terms of their compositions, molecular weights and behavior at the air–water interface using 1H‐NMR spectroscopy, thermogravimetric analysis, gel permeation chromatography, surface tension, transmission electron microscopy (TEM) and dynamic light scattering respectively. The results indicated that PMA‐PAA‐PMA was successfully synthesized through RAFT polymerization. The polydispersity index (PDI) decreased when the molar ratio [n(MA)/n(AA)] increased, the lowest PDI was obtained at 5.23 wt% RAFT and the molecular weights were consistent with the theoretical value as the RAFT agent percentage varied. The polymer neutralized by sodium hydroxide solution shows a low critical micelle concentration (CMC), which was <10?2 mol L?1 in water. The Amin values increased and showed a maximum with decreased AA chain length. TEM showed that the neutralized polymer formed a special vesicle structure with large pore structure which led to a low CMC and surface tension of water. 相似文献
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Broggi Andrea Tangstad Merete Ringdalen Eli 《Metallurgical and Materials Transactions B》2019,50(6):2667-2680
Metallurgical and Materials Transactions B - The reaction between SiO(g) and CO(g) is a relevant intermediate reaction in the silicon production process. One of the products generated from this gas... 相似文献
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Eli Vandersluis Comondore Ravindran 《Transactions of the Indian Institute of Metals》2018,71(5):1231-1236
The design of improved casting systems requires accurate modeling of metal cooling processes. This can only be accomplished after determining the interfacial heat transfer coefficient (IHTC) between a solidifying casting and its mould. In the current work, a simple and robust inverse heat conduction technique was applied for the estimation of the effective IHTC between an aluminum alloy casting and a steel permanent mould during solidification. The solidification of the alloy at varying mould preheating temperatures was monitored using a thermocouple, and the experimental cooling curves were compared with curves simulated by casting solidification modeling software. The IHTC value applied to the software was varied until its output converged with the experimental data, leading to an estimation of 6000 W/m2K for this system. This technique is useful as a preliminary tool in materials modeling, and it will promote the development of improved casting processes without the need for excessive experimentation. 相似文献
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Christopher Koenigsmann Zhibo Tan Huiqing Peng Eli Sutter Jared Jacobskind Stanislaus S. Wong 《Israel journal of chemistry》2012,52(11-12):1090-1103
Segmented noble-metal nanowires (NWs) represent an exciting, multifunctional, one-dimensional, structural architecture with a variety of potential applications. However, the widespread use of electrodeposition in the preparation of these systems has limited their potential to be produced on a large scale, since this protocol is costly and requires complex processes and caustic reaction media. Given the inherent limitations of electrodeposition, we report, for the first time, an ambient, surfactantless, template-based approach that is not only sustainable but also efficient for the reliable production of Pd/Pt and Pd/Au segmented NWs, possessing two spatially separated, chemically distinctive, but elementally pure, axial subunits. Our simple two-step synthetic approach allows for direct and predictable control over the relative segment lengths in these nanomaterials. Moreover, thorough structural characterization of these as-prepared samples confirms that our segmented NWs maintain high-quality, crystalline, elementally pure subunits with a well-defined interface between the constituent metals. In the context of preparing segmented NWs as multifunctional nanostructures, we demonstrate that these as-prepared NWs achieve high levels of performance when employed as both electrocatalysts and nanomotors. 相似文献
10.
Asllan Hajderi Eli Vyshka 《机械工程与自动化:英文版》2014,(10):799-803
In this study, it shows how the main indicators of torsional vibrations of the crankshaft change when its materials change. In the study, the crankshaft of diesel engine with four cylinders in line was taken, in which the material is changing from steel to cast iron, due to the technological possibilities of production. For study of torsional vibration of crankshaft system, the construction of equivalent reduced scheme is carried. Reduced inertia moments of discs are determined for each crank of crankshaft, by receiving the impact of piston group and rod mass. Reduced rigidities of crank are determined by experimental method. The results show that the rigidity of crank for the same crankshaft varies up to 6%, while the change between crankshafts goes up 10%. At the end, frequency and vibration forms are calculated using Tole-Holxer method. From calculations, it results that the frequencies are 19% smaller, while the vibration forms varies slightly. In this case, the change of the materials leads to the first frequency in the area of engine rotations and it can worsen the level of torsional vibration, therefore, it should check the resonance areas and vibration amplitude. 相似文献