全文获取类型
收费全文 | 324篇 |
免费 | 31篇 |
国内免费 | 1篇 |
专业分类
电工技术 | 7篇 |
化学工业 | 75篇 |
金属工艺 | 6篇 |
机械仪表 | 13篇 |
建筑科学 | 6篇 |
矿业工程 | 1篇 |
能源动力 | 4篇 |
轻工业 | 90篇 |
水利工程 | 1篇 |
石油天然气 | 2篇 |
无线电 | 17篇 |
一般工业技术 | 54篇 |
冶金工业 | 41篇 |
原子能技术 | 3篇 |
自动化技术 | 36篇 |
出版年
2024年 | 1篇 |
2023年 | 4篇 |
2022年 | 6篇 |
2021年 | 17篇 |
2020年 | 10篇 |
2019年 | 14篇 |
2018年 | 16篇 |
2017年 | 15篇 |
2016年 | 18篇 |
2015年 | 16篇 |
2014年 | 22篇 |
2013年 | 31篇 |
2012年 | 29篇 |
2011年 | 19篇 |
2010年 | 14篇 |
2009年 | 10篇 |
2008年 | 11篇 |
2007年 | 9篇 |
2006年 | 12篇 |
2005年 | 6篇 |
2004年 | 11篇 |
2003年 | 2篇 |
2002年 | 8篇 |
2001年 | 6篇 |
2000年 | 2篇 |
1999年 | 3篇 |
1998年 | 11篇 |
1997年 | 5篇 |
1996年 | 6篇 |
1993年 | 2篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1987年 | 3篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1977年 | 1篇 |
1975年 | 1篇 |
1972年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有356条查询结果,搜索用时 125 毫秒
1.
Dr. Eduarda Mendes Enrico Cadoni Filipa Carneiro Dr. Marta B. Afonso Hugo Brito Dr. João Lavrado Dr. Daniel J. V. A. dos Santos Dr. Jorge B. Vítor Prof. Stephen Neidle Prof. Cecília M. P. Rodrigues Prof. Alexandra Paulo 《ChemMedChem》2019,14(14):1325-1328
Quadruplex nucleic acids are promising targets for cancer therapy. In this study we used a fragment-based approach to create new flexible G-quadruplex (G4) DNA-interactive small molecules with good calculated oral drug-like properties, based on quinoline and triazole heterocycles. G4 melting temperature and polymerase chain reaction (PCR)-stop assays showed that two of these compounds are selective G4 ligands, as they were able to induce and stabilize G4s in a dose- and DNA sequence-dependent manner. Molecular docking studies have suggested plausible quadruplex binding to both the G-quartet and groove, with the quinoline module playing the major role. Compounds were screened for cytotoxicity against four cancer cell lines, where 4,4′-(4,4′-(1,3-phenylene)bis(1H-1,2,3-triazole-4,1-diyl))bis(1-methylquinolin-1-ium) ( 1 d ) showed the greater activity. Importantly, dose–response curves show that 1 d is cytotoxic in the human colon cancer HT-29 cell line enriched in cancer stem-like cells, a subpopulation of cells implicated in chemoresistance. Overall, this study identified a new small molecule as a promising lead for the development of drugs targeting G4 in cancer stem cells. 相似文献
2.
Angelova Anelia Carneiro Gustavo Sünderhauf Niko Leitner Jürgen 《International Journal of Computer Vision》2020,128(5):1160-1161
International Journal of Computer Vision - 相似文献
3.
4.
Filipa Quintela Vieira ngela Marques-Magalhes Vera Miranda-Gonalves Ricardo Ferraz Mnica Vieira Cristina Prudêncio Carmen Jernimo Regina Augusta Silva 《International journal of molecular sciences》2020,21(24)
Breast (BrCa) and prostate (PCa) cancers are the most common malignancies in women and men, respectively. The available therapeutic options for these tumors are still not curative and have severe side effects. Therefore, there is an urgent need for more effective antineoplastic agents. Herein, BrCa, PCa, and benign cell lines were treated with two ionic liquids and two quinoxalines and functional experiments were performed—namely cell viability, apoptosis, cytotoxicity, and colony formation assays. At the molecular level, an array of gene expressions encompassing several molecular pathways were used to explore the impact of treatment on gene expression. Although both quinoxalines and the ionic liquid [C2OHMIM][Amp] did not show any effect on the BrCa and PCa cell lines, [C16Pyr][Amp] significantly decreased cell viability and colony formation ability, while it increased the apoptosis levels of all cell lines. Importantly, [C16Pyr][Amp] was found to be more selective for cancer cells and less toxic than cisplatin. At the molecular level, this ionic liquid was also associated with reduced expression levels of CPT2, LDHA, MCM2, and SKP2, in both BrCa and PCa cell lines. Hence, [C16Pyr][Amp] was shown to be a promising anticancer therapeutic agent for BrCa and PCa cell lines. 相似文献
5.
ABSTRACTA growing number of workers, particularly in the knowledge and service sectors, can perform their work at multiple locations, and it is decreasingly realistic to assume, as researchers and planners have traditionally done, that employment in cities occurs in fixed locations. This suggests that census data or establishment registries do not fully capture where economic activity takes place. Given the role that ICTs play in enabling daytime workplace mobility, and given that they generate substantial amounts of real-time, geolocated data, we ask whether these Big Data can shed light upon the trajectories of mobile workers at the urban scale. 相似文献
6.
Preparation and properties of polyamide‐6‐based thermoplastic laminate composites by a novel in‐mold polymerization technique 下载免费PDF全文
Nadya Dencheva Ana S. Sampaio Filipa M. Oliveira António S. Pouzada Antonio M. Brito Zlatan Denchev 《应用聚合物科学杂志》2014,131(8)
In this work, a method for preparation of polyamide‐6 (PA6) based laminates reinforced by glass fiber‐ (GFL) or polyamide‐66 (PA66) textile structures (PL) via reactive injection molding is disclosed. It is based on in‐mold anionic polymerization of ε‐caprolactam carried out at 165°C in the presence of the respective reinforcements performed in newly developed prototype equipment whose design concept and operation are described. Both composite types were produced for reaction times of 20 min, with conversion degrees of 97–99%. Initial mechanical tests in tension of GFL samples displayed almost twofold increase of the Young's modulus and stress at break values when compared with the neat anionic PA6. The improvement was proportional to the volume fraction Vf of glass fiber fabric that was varied in the 0.16–0.25 range. A 300% growth of the impact strength was registered in PL composites with Vf of PA66 textile of 0.1. Removing the surface finish of the latter was found to be a factor for improving the adhesion at the matrix–fiber interface. The mechanical behavior of GFL and PL composites was discussed in conjunction with the morphology of the samples studied by optical and electron microscopy and the matrix crystalline structure as revealed by synchrotron X‐ray diffraction. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 40083. 相似文献
7.
Dr. Louis Adriaenssens Dr. Qiang Liu Dr. Fanny Chaux‐Picquet Dr. Semra Tasan Dr. Michel Picquet Prof. Franck Denat Prof. Pierre Le Gendre Dr. Fernanda Marques Dr. Célia Fernandes Dr. Filipa Mendes Dr. Lurdes Gano Dr. Maria Paula Cabral Campello Dr. Ewen Bodio 《ChemMedChem》2014,9(7):1567-1573
A novel RuII(arene) theranostic complex is presented. It is based on a 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid macrocycle bearing a triarylphosphine and can be tracked in vivo by using the γ emission of 153Sm atoms. Notably, the heteroditopic ligand can be selectively metalated with ruthenium at the phosphorus atom despite the presence of other functionalities that are prone to metal coordination. Subsequent labeling with radionuclides such as 153Sm can then be performed easily. The resulting heterobimetallic complex exhibits favorable solubility and stability properties in biologically relevant media. It also shows in vitro cytotoxicity in line with that expected for this type of metallodrug, and is nontoxic to the organism as a whole. As a proof of concept, initial studies in healthy mice were performed to obtain information about the uptake, biodistribution, and excretion of the radiolabeled complex. 相似文献
8.
Clemente Neves Sousa Paulo Teles Vanessa Filipa Ferreira Dias João Luís Alves Apóstolo Maria Henriqueta Jesus Silva Figueiredo Maria Manuela Martins 《Hemodialysis international. International Symposium on Home Hemodialysis》2014,18(3):695-699
Vascular access is one of the leading causes of mobilization of financial resources in health systems for people with chronic kidney disease on hemodialysis. Physical examination of the arteriovenous fistula (AVF) has demonstrated its effectiveness in identifying complications. We decided to evaluate the influence of nurses' professional experience in the detection of complications of the AVF (venous stenosis and steal syndrome). The study took place in eight hemodialysis centers between May and September of 2011 in the north of Portugal. Sample was constituted by registered nurses. The nurses involved in the experiment were divided in two groups: those who had more than 5 years of experience and those who had less than 5 years of experience. Ninety‐two nurses participated in the study: 34 nurses had less than 5 years of professional experience and 58 had more than 5 years of professional experience. In the practices considered by nurses in the detection of venous stenosis, there were no differences observed between the groups (P > 0.05). In steal syndrome, there were no differences observed between the groups in the practices of the nurses in the detection of this complication of the AVF (P > 0.05). We concluded that professional experience does not influence the detection of venous stenosis and steal syndrome. 相似文献
9.
Vincenza Ferraro Ruben Ferreira Jorge Isabel B. Cruz Filipa Antunes Bruno Sarmento Paula M. L. Castro Manuela E. Pintado 《International Journal of Food Science & Technology》2014,49(1):27-33
This study reports on the intestinal permeability of salt‐containing mixtures of amino acids extracted from codfish salting wastewater. Permeability was evaluated in vitro using the Caco‐2 cell line model; cell integrity during exposure to mixtures of amino acids was estimated by measuring the transepithelial electrical resistance (TEER). The effect of salt (NaCl) on the permeability and on the intestinal cell's integrity was also examined. Permeation rate (i.e. transport) was ≥95% for all amino acids except for creatine, for which it was 6%. Values for apparent permeability coefficients, Papp > 10?5 cm s?1, for mixture with isotonic concentration of NaCl suggest that amino acids are very likely to be absorbed in humans. Mixture with a hypertonic level of NaCl exerts a cytotoxic effect in intestinal cells resulting in a loss of epithelium integrity. Results show that isotonic mixture of amino acids extracted from codfish salting wastewater could be used in food, feed, cosmetic and pharmaceutical formulations. These applications could contribute to the fish industry sustainability. 相似文献
10.
Auxetic materials are endowed with a behavior that contradicts common sense, when subjected to an axial tensile load they increase their transverse dimension. In case of a compression load, they reduce their transverse dimension. Consequently, these materials have a negative Poisson’s ratio in such direction. This paper reviews research related to these materials. It presents the theories that explain their deformation behavior and reveals the important role represented by the internal structure. Their mechanical properties are explored and some potential applications for these materials are shown. 相似文献