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1.
Miguel Pallares Davide Fascione Gianluca Iannotta Alessandro Laner Alessandro Leanti Enrico Pellegrini Jenny Spagnolatti Santiago Trujillo Anna Zauli Andrea Martiradonna 《世界建筑导报》2018,(5)
正Piuarch建筑师事务所负责设计了2015年米兰世博会埃内尔(意大利国家电力公司)展馆及卡里塔斯展馆。为了将客户想表达的含义与价值观更好地传达给观众,Piuarch选择了一种特殊的建筑语言来体现两个展馆的特点。埃内尔展馆沿东西大街而建,占地900平方米。设计体现出智能电网这一概念,传达出以智能科技优化世博会整体用电的理念。 相似文献
2.
Bocciarelli Massimiliano Ranzi Gianluca 《Structural and Multidisciplinary Optimization》2020,61(1):91-110
Structural and Multidisciplinary Optimization - Hygro-thermo-chemical-mechanical models, used to determine the variations over time of temperature, relative humidity and shrinkage induced... 相似文献
3.
Francesco Centurelli Pietro Monsurrò Vincenzo Stornelli Gianluca Barile Alessandro Trifiletti 《International Journal of Circuit Theory and Applications》2020,48(4):472-484
A 4th-order Butterworth class-AB current-mode low-pass filter is proposed, based on second-generation Current Conveyors (CCII). Class-AB operation allows high-power efficiency and driving large loads with small quiescent currents. The CCII topology uses the class-AB output buffer with error amplifiers: this topology is known to be sensitive to mismatch errors, which cause offsets in the error amplifiers, affecting the biasing current of the stage. This problem is solved via a control loop, which compensates the effect of mismatches. The technique is shown to be effective in Monte Carlo simulations with process variations and mismatches. Simulations have been carried out in 40 nm CMOS technology. The proposed filter achieves good power efficiency, thanks to the class-AB architecture, and good dynamic range, thanks to the closed-loop output buffer. A cut-off frequency of 6 MHz, with 184 μW of total quiescent power consumption, is achieved, with a THD of -55 dB and a SNR of 49 dB. 相似文献
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Bernardeschi Cinzia Dini Gianluca Palmieri Maurizio Racciatti Francesco 《Journal in Computer Virology》2021,17(3):249-263
Journal of Computer Virology and Hacking Techniques - When designing Wireless Sensor Networks it is important to analyze their security risks and provide adequate solutions for protecting them from... 相似文献
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Anticancer Ruthenium(III) Complex KP1019 Interferes with ATP‐Dependent Ca2+ Translocation by Sarco‐Endoplasmic Reticulum Ca2+‐ATPase (SERCA) 下载免费PDF全文
Fabrizio‐Zagros Sadafi Lara Massai Dr. Gianluca Bartolommei Prof. Maria Rosa Moncelli Prof. Luigi Messori Dr. Francesco Tadini‐Buoninsegni 《ChemMedChem》2014,9(8):1660-1664
Sarco‐endoplasmic reticulum Ca2+‐ATPase (SERCA), a P‐type ATPase that sustains Ca2+ transport and plays a major role in intracellular Ca2+ homeostasis, represents a therapeutic target for cancer therapy. Here, we investigated whether ruthenium‐based anticancer drugs, namely KP1019 (indazolium [trans‐tetrachlorobis(1H‐indazole)ruthenate(III)]), NAMI‐A (imidazolium [trans‐tetrachloro(1H‐imidazole)(S‐dimethylsulfoxide)ruthenate(III)]) and RAPTA‐C ([Ru(η6‐p‐cymene)dichloro(1,3,5‐triaza‐7‐phosphaadamantane)]), and cisplatin (cis‐diammineplatinum(II) dichloride) might act as inhibitors of SERCA. Charge displacement by SERCA adsorbed on a solid‐supported membrane was measured after ATP or Ca2+ concentration jumps. Our results show that KP1019, in contrast to the other metal compounds, is able to interfere with ATP‐dependent translocation of Ca2+ ions. An IC50 value of 1 μM was determined for inhibition of calcium translocation by KP1019. Conversely, it appears that KP1019 does not significantly affect Ca2+ binding to the ATPase from the cytoplasmic side. Inhibition of SERCA at pharmacologically relevant concentrations may represent a crucial aspect in the overall pharmacological and toxicological profile of KP1019. 相似文献
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Sara Gnavi Benedetta Elena Fornasari Chiara Tonda-Turo Rossella Laurano Marco Zanetti Gianluca Ciardelli Stefano Geuna 《International journal of molecular sciences》2015,16(6):12925-12942
Electrospun fibrous substrates mimicking extracellular matrices can be prepared by electrospinning, yielding aligned fibrous matrices as internal fillers to manufacture artificial nerves. Gelatin aligned nano-fibers were prepared by electrospinning after tuning the collector rotation speed. The effect of alignment on cell adhesion and proliferation was tested in vitro using primary cultures, the Schwann cell line, RT4-D6P2T, and the sensory neuron-like cell line, 50B11. Cell adhesion and proliferation were assessed by quantifying at several time-points. Aligned nano-fibers reduced adhesion and proliferation rate compared with random fibers. Schwann cell morphology and organization were investigated by immunostaining of the cytoskeleton. Cells were elongated with their longitudinal body parallel to the aligned fibers. B5011 neuron-like cells were aligned and had parallel axon growth when cultured on the aligned gelatin fibers. The data show that the alignment of electrospun gelatin fibers can modulate Schwann cells and axon organization in vitro, suggesting that this substrate shows promise as an internal filler for the design of artificial nerves for peripheral nerve reconstruction. 相似文献
10.
Tunable Quantum Confinement in Ultrathin,Optically Active Semiconductor Nanowires Via Reverse‐Reaction Growth 下载免费PDF全文