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1.
基于千年生态系统评估对生态系统服务的分类方法,将天津市地下水生态系统服务功能划分为供给、调节、
支持和文化 4 个方面,以此为基础建立地下水生态系统服务价值评估指标体系,采用价值量评估方法构建货币化
的价值评估模型,对地下水生态系统服务价值进行测算,并重点分析南水北调中线工程通水前后天津市地下水生
态系统服务价值演变特征。结果表明:2008—2019 年,天津市地下水生态系统年均总服务价值为 83.71 亿元,其
中,南水北调中线工程通水前(2008—2014 年)为 69.81 亿元,通水后(2015—2019 年)为 103.18 亿元;通水后,地
下水调节服务价值、支持服务价值增大,供给服务价值减小;南水北调中线工程对地下水生态系统服务价值的贡
献呈增大趋势,由 2015 年 2.64 亿元增加至 2019 年 24.01 亿元。 相似文献
2.
基于历史实测降水数据与全球气候模型预估数据,使用 Morlet 小波方法分析滇中引水工程水源区与受水区
降水序列的周期变化和未来的降水趋势。同时,采用 Copula 函数计算历史时期(1960—2021 年)与未来时期
(2022—2100 年)水源区与受水区降水丰枯异步或丰枯同步的概率。结果表明:1960—2021 年降水序列存在
26~39?a、18~25?a、4~7?a 的 3 类时间尺度的周期变化,2022—2100 年降水序列存在 38~55?a、18~30?a、5~12?a 的 3
类时间尺度的周期变化,降水量呈现“多—少—多”的循环交替,预计未来 10~20?a 将持续处于降水较多的时期;
过去 62?a,水源区和受水区降水丰枯异步频率 36.4%,同期丰水年频率为 25.3%,同期枯水年频率小于 30%,水源区
和受水区具有水量互补的引水条件,两区域之间存在着水量补偿特征;与历史丰枯遭遇对比,未来降水量丰枯同
步频率均呈现减小的趋势,丰枯异步呈现增加的趋势,同枯和源枯受丰的频率减少,未来有利于调水的降水丰枯
组合概率平均增加 3.75%;在近、中、远期预估中,从 SSP1-2.6 情景过渡到 SSP5-8.5 情景,SSP5-8.5 情景下降水量
丰枯异步频率比 SSP1-2.6 情景大,说明水源区与受水区的降水区域差异变大,降水时空差异更加显著。通过对滇
中引水工程水源区与受水区降水量丰枯遭遇的综合分析、定量评估和模拟预测,为滇中引水工程水资源调度协同
一体化提供数据支撑及参考依据。 相似文献
3.
So Young Kim Cheol Park Min Yeong Kim Seon Yeong Ji Hyun Hwangbo Hyesook Lee Su Hyun Hong Min Ho Han Jin-Woo Jeong Gi-Young Kim Chang-Gue Son JaeHun Cheong Yung Hyun Choi 《International journal of molecular sciences》2021,22(9)
Coptidis Rhizoma is the dried rhizome from the Coptis chinensis Franch. that has been shown to have a number of beneficial pharmacological properties including antioxidant, anti-inflammatory, and anti-cancer effects. However, the anti-cancer effects of Coptidis Rhizoma on hepatocellular carcinoma (HCC) remain unclear. In this study, we investigated the anti-cancer properties of Coptidis Rhizoma ethanol extract (CR) in HCC Hep3B cells and in a xenograft mouse model. Our results showed that the CR significantly inhibited cell growth and induced apoptosis in Hep3B cells through increased expression of Bcl-2 associated x-protein (Bax) and cleavage of poly-ADP ribose polymerase (PARP), reduced expression of Bcl-2, and activated caspases. CR also increased the generation of intracellular reactive oxygen species (ROS), which caused a loss of mitochondrial membrane potential (MMP, ΔΨm) and activation of the mitochondria-mediated intrinsic apoptosis pathway. Moreover, N-acetylcysteine (NAC), a ROS inhibitor, markedly blocked the effects of CR on apoptotic pathways. CR also induced the expression of light chain 3 (LC3)-I/II, a key autophagy regulator, whereas CR-mediated autophagy was significantly suppressed by NAC. In addition, pre-treatment with NAC perfectly attenuated the inhibition of cell invasion and migration of CR-stimulated Hep3B cells. Furthermore, oral administration of CR suppressed Hep3B tumor growth in xenograft mice without toxicity, alterations to body weight, or changes in hematological and biochemical profiles. Taken together, our findings suggest that CR has anti-tumor effects that result from ROS generation, and may be a potential pharmacological intervention for HCC. 相似文献
4.
Dr. Dae-Shik Kim Dr. Atsushi Endo Dr. Francis G. Fang Dr. Kuan-Chun Huang Dr. Xingfeng Bao Dr. Hyeong-wook Choi Dr. Utpal Majumder Dr. Young Y. Shen Steven Mathieu Xiaojie Zhu Kristen Sanders Dr. Thomas Noland Dr. Ming-Hong Hao Dr. Yu Chen Dr. John Y. Wang So Yasui Karen TenDyke Jiayi Wu Christy Ingersoll Kara A. Loiacono Dr. Janna E. Hutz Dr. Nadeem Sarwar 《ChemMedChem》2021,16(11):1741-1744
A strategy for creating potent and pan-genotypic stimulator of interferon genes (STING) agonists is described. Locking a bioactive U-shaped conformation of cyclic dinucleotides by introducing a transannular macrocyclic bridge between the nucleic acid bases leads to a topologically novel macrocycle-bridged STING agonist (MBSA). In addition to substantially enhanced potency, the newly designed MBSAs, exemplified by clinical candidate E7766 , exhibit broad pan-genotypic activity in all major human STING variants. E7766 is shown to have potent antitumor activity with long lasting immune memory response in a mouse liver metastatic tumor model. Two complementary stereoselective synthetic routes to E7766 are also described. 相似文献
5.
Kyuri Kim Young Seung Lee Nam Kim Hyung-Do Choi Dong-Jun Kang Hak Rim Kim Kyung-Min Lim 《International journal of molecular sciences》2021,22(1)
With the rapid growth of wireless communication devices, the influences of electromagnetic fields (EMF) on human health are gathering increasing attention. Since the skin is the largest organ of the body and is located at the outermost layer, it is considered a major target for the health effects of EMF. Skin pigmentation represents one of the most frequent symptoms caused by various non-ionizing radiations, including ultraviolet radiation, blue light, infrared, and extremely low frequency (ELF). Here, we investigated the effects of EMFs with long-term evolution (LTE, 1.762 GHz) and 5G (28 GHz) bandwidth on skin pigmentation in vitro. Murine and Human melanoma cells (B16F10 and MNT-1) were exposed to either LTE or 5G for 4 h per day, which is considered the upper bound of average smartphone use time. It was shown that neither LTE nor 5G exposure induced significant effects on cell viability or pigmentation. The dendrites of MNT-1 were neither lengthened nor regressed after EMF exposure. Skin pigmentation effects of EMFs were further examined in the human keratinocyte cell line (MNT-1-HaCaT) co-culture system, which confirmed the absence of significant hyper-pigmentation effects of LTE and 5G EMFs. Lastly, MelanoDerm™, a 3D pigmented human epidermis model, was irradiated with LTE (1.762 GHz) or 5G (28 GHz), and image analysis and special staining were performed. No changes in the brightness of MelanoDerm™ tissues were observed in LTE- or 5G-exposed tissues, except for only minimal changes in the size of melanocytes. Collectively, these results imply that exposure to LTE and 5G EMFs may not affect melanin synthesis or skin pigmentation under normal smartphone use condition. 相似文献
6.
Myoung Su Choi Hyungtaek Jeon Seung-Min Yoo Myung-Shin Lee 《International journal of molecular sciences》2021,22(7)
Exposure to particulate matter (PM) is becoming a major global health issue. The amount and time of exposure to PM are known to be closely associated with cardiovascular diseases. However, the mechanism through which PM affects the vascular system is still not clear. Endothelial cells line the interior surface of blood vessels and actively interact with plasma proteins, including the complement system. Unregulated complement activation caused by invaders, such as pollutants, may promote endothelial inflammation. In the present study, we sought to investigate whether urban PM (UPM) acts on the endothelial environment via the complement system. UPM-treated human endothelial cells with normal human serum showed the deposition of membrane attack complexes (MACs) on the cell surface via the alternative pathway of the complement system. Despite the formation of MACs, cell death was not observed, and cell proliferation was increased in UPM-mediated complement activation. Furthermore, complement activation on endothelial cells stimulated the production of inflammation-related proteins. Our results revealed that UPM could activate the complement system in human endothelial cells and that complement activation regulated inflammatory reaction in microenvironment. These findings provide clues with regard to the role of the complement system in pathophysiologic events of vascular disease elicited by air pollution. 相似文献
7.
Hyun Sun Choi Yun Kee Jo Gwang-Noh Ahn Kye Il Joo Dong-Pyo Kim Hyung Joon Cha 《Advanced functional materials》2021,31(46):2104602
The esophagus is a tubular-shaped muscular organ where swallowed fluids and muscular contractions constitute a highly dynamic environment. The turbulent, coordinated processes that occur through the oropharyngeal conduit can often compromise targeted administration of therapeutic drugs to a lesion, significantly reducing therapeutic efficacy. Here, magnetically guidable drug vehicles capable of strongly adhering to target sites using a bioengineered mussel adhesive protein (MAP) to achieve localized delivery of therapeutic drugs against the hydrodynamic physiological conditions are proposed. A suite of highly uniform microparticles embedded with iron oxide (IO) nanoparticles (MAP@IO MPs) is microfluidically fabricated using the genipin-mediated covalent cross-linking of bioengineered MAP. The MAP@IO MPs are successfully targeted to a specific region and prolongedly retained in the tubular-structured passageway. In particular, orally administered MAP@IO MPs are effectively captured in the esophagus in vivo in a magnetically guidable manner. Moreover, doxorubicin (DOX)-loaded MAP@IO MPs exhibit a sustainable DOX release profile, effective anticancer therapeutic activity, and excellent biocompatibility. Thus, the magnetically guidable locomotion and robust underwater adhesive properties of the proteinaceous soft microbots can provide an intelligent modular approach for targeted locoregional therapeutics delivery to a specific lesion site in dynamic fluid-associated tubular organs such as the esophagus. 相似文献
8.
Xiaoqin Yang Huy Q. Ta Huimin Hu Shuyuan Liu Yu Liu Alicja Bachmatiuk Jinping Luo Lijun Liu Jin-Ho Choi Mark H. Rummeli 《Advanced functional materials》2021,31(38):2104340
In this study, in situ transmission electron microscopy is performed to study the interaction between single (monomer) and paired (dimer) Sn atoms at graphene edges. The results reveal that a single Sn atom can catalyze both the growth and etching of graphene by the addition and removal of C atoms respectively. Additionally, the frequencies of the energetically favorable configurations of an Sn atom at a graphene edge, calculated using density functional theory calculations, are compared with experimental observations and are found to be in good agreement. The remarkable dynamic processes of binary atoms (dimers) are also investigated and is the first such study to the best of the knowledge. Dimer diffusion along the graphene edges depends on the graphene edge termination. Atom pairs (dimers) involving an armchair configuration tend to diffuse with a synchronized shuffling (step-wise shift) action, while dimer diffusion at zigzag edge terminations show a strong propensity to collapse the dimer with each atom diffusing in opposite directions (monomer formation). Moreover, the data reveals the role of C feedstock availability on the choice a single Sn atom makes in terms of graphene growth or etching. This study advances the understanding single atom catalytic activity at graphene edges. 相似文献
9.
Hend Omar Mohamed Enas Taha Sayed M. Obaid Yun-Jeong Choi Sung-Gwan Park Siham Al-Qaradawi Kyu-Jung Chae 《International Journal of Hydrogen Energy》2018,43(46):21560-21571
The poor wettability and high cost of the carbonaceous electrodes materials prohibited the practical applications of microbial fuel cells (MFCs) on large scale. Here, a novel nanoparticles of metal sheathed with metal oxide is electrodeposited on carbon paper (CP) to introduce as high-performance anodes of microbial fuel cell (MFC). This thin layer of metal/metal oxide significantly enhance the microbial adhesion, the wettability of the anode surface and decrease the electron transfer resistance. The investigation of the modified CP anodes in an air-cathode MFCs fed by various biocatalyst cultures shows a significant improving in the MFC performance. Where, the generated power and current density was 140% and 210% higher as compared to the pristine CP. Mixed culture of exoelectrogenic microorganism in wastewater exhibited good performance and generated higher power and current density compared to yeast as pure culture. The excellent capacitance with a distinctive nanostructure morphology of the modified-CP open an avenues for practical applications of MFCs. 相似文献
10.
Manjunatha S. Muttigi Byoung Ju Kim Bogyu Choi Inbo Han Hansoo Park Soo-Hong Lee 《International journal of molecular sciences》2020,21(23)
Adipose-derived mesenchymal stromal cells (Ad-MSCs) are a promising tool for articular cartilage repair and regeneration. However, the terminal hypertrophic differentiation of Ad-MSC-derived cartilage is a critical barrier during hyaline cartilage regeneration. In this study, we investigated the role of matrilin-3 in preventing Ad-MSC-derived chondrocyte hypertrophy in vitro and in an osteoarthritis (OA) destabilization of the medial meniscus (DMM) model. Methacrylated hyaluron (MAHA) (1%) was used to encapsulate and make scaffolds containing Ad-MSCs and matrilin-3. Subsequently, the encapsulated cells in the scaffolds were differentiated in chondrogenic medium (TGF-β, 1–14 days) and thyroid hormone hypertrophic medium (T3, 15–28 days). The presence of matrilin-3 with Ad-MSCs in the MAHA scaffold significantly increased the chondrogenic marker and decreased the hypertrophy marker mRNA and protein expression. Furthermore, matrilin-3 significantly modified the expression of TGF-β2, BMP-2, and BMP-4. Next, we prepared the OA model and transplanted Ad-MSCs primed with matrilin-3, either as a single-cell suspension or in spheroid form. Safranin-O staining and the OA score suggested that the regenerated cartilage morphology in the matrilin-3-primed Ad-MSC spheroids was similar to the positive control. Furthermore, matrilin-3-primed Ad-MSC spheroids prevented subchondral bone sclerosis in the mouse model. Here, we show that matrilin-3 plays a major role in modulating Ad-MSCs’ therapeutic effect on cartilage regeneration and hypertrophy suppression. 相似文献