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排序方式: 共有417条查询结果,搜索用时 46 毫秒
1.
Patrycja Kaczara Kamil Przyborowski Tasnim Mohaissen Stefan Chlopicki 《International journal of molecular sciences》2021,22(7)
Carbon monoxide (CO)—gaseous or released by CO-RMs—both possess antiplatelet properties; however, it remains uncertain whether the mechanisms involved are the same. Here, we characterise the involvement of soluble guanylate cyclase (sGC) in the effects of CO—delivered by gaseous CO–saturated buffer (COG) and generated by CORM-A1—on platelet aggregation and energy metabolism, as well as on vasodilatation in aorta, using light transmission aggregometry, Seahorse XFe technique, and wire myography, respectively. ODQ completely prevented the inhibitory effect of COG on platelet aggregation, but did not modify antiplatelet effect of CORM-A1. In turn, COG did not affect, whereas CORM-A1 substantially inhibited energy metabolism in platelets. Even though activation of sGC by BAY 41-2272 or BAY 58-2667 inhibited significantly platelet aggregation, their effects on energy metabolism in platelets were absent or weak and could not contribute to antiplatelet effects of sGC activation. In contrast, vasodilatation of murine aortic rings, induced either by COG or CORM-A1, was dependent on sGC. We conclude that the source (COG vs. CORM-A1) and kinetics (rapid vs. slow) of CO delivery represent key determinants of the mechanism of antiplatelet action of CO, involving either impairment of energy metabolism or activation of sGG. 相似文献
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Ci̇velekler Ebru Okur Volkan D. Afacan Kamil B. 《Bulletin of Engineering Geology and the Environment》2021,80(7):5589-5607
Bulletin of Engineering Geology and the Environment - Local soil characteristics play a key role in determining soil-structure interaction and reliability of the superstructure behavior under... 相似文献
4.
Jiri Patocka Ran Wu Eugenie Nepovimova Martin Valis Wenda Wu Kamil Kuca 《International journal of molecular sciences》2021,22(4)
Mushroom poisoning has always been a threat to human health. There are a large number of reports about ingestion of poisonous mushrooms every year around the world. It attracts the attention of researchers, especially in the aspects of toxin composition, toxic mechanism and toxin application in poisonous mushroom. Inocybe is a large genus of mushrooms and contains toxic substances including muscarine, psilocybin, psilocin, aeruginascin, lectins and baeocystin. In order to prevent and remedy mushroom poisoning, it is significant to clarify the toxic effects and mechanisms of these bioactive substances. In this review article, we summarize the chemistry, most known toxic effects and mechanisms of major toxic substances in Inocybe mushrooms, especially muscarine, psilocybin and psilocin. Their available toxicity data (different species, different administration routes) published formerly are also summarized. In addition, the treatment and medical application of these toxic substances in Inocybe mushrooms are also discussed. We hope that this review will help understanding of the chemistry and toxicology of Inocybe mushrooms as well as the potential clinical application of its bioactive substances to benefit human beings. 相似文献
5.
Adamczyk-Cieślak Bogusława Koralnik Milena Kuziak Roman Majchrowicz Kamil Mizera Jarosław 《Metallurgical and Materials Transactions A》2021,52(12):5429-5442
Metallurgical and Materials Transactions A - This paper describes the development and characterisation of bainitic steel for rail applications based on carbide-free, low-alloy steel. The results... 相似文献
6.
Xuan Tang Teseo Schneider Shoaib Kamil Aurojit Panda Jinyang Li Daniele Panozzo 《Computer Graphics Forum》2020,39(5):209-219
Sparse matrix computations are among the most important computational patterns, commonly used in geometry processing, physical simulation, graph algorithms, and other situations where sparse data arises. In many cases, the structure of a sparse matrix is known a priori, but the values may change or depend on inputs to the algorithm. We propose a new methodology for compile-time specialization of algorithms relying on mixing sparse and dense linear algebra operations, using an extension to the widely-used open source Eigen package. In contrast to library approaches optimizing individual building blocks of a computation (such as sparse matrix product), we generate reusable sparsity-specific implementations for a given algorithm, utilizing vector intrinsics and reducing unnecessary scanning through matrix structures. We demonstrate the effectiveness of our technique on a benchmark of artificial expressions to quantitatively evaluate the benefit of our approach over the state-of-the-art library Intel MKL. To further demonstrate the practical applicability of our technique we show that our technique can improve performance, with minimal code changes, for mesh smoothing, mesh parametrization, volumetric deformation, optical flow, and computation of the Laplace operator. 相似文献
7.
Maj Justyna Węglewski Witold Bochenek Kamil Rogal Łukasz Woźniacka Stefania Basista Michał 《Metallurgical and Materials Transactions A》2021,52(11):4727-4736
Squeeze casting and powder metallurgy techniques were employed to fabricate AlSi12/Al2O3 composites, which are lightweight structural materials with potential applications in the automotive industry. The impact of the processing route on the material properties was studied. Comparative analyses were conducted for the Vickers hardness, flexural strength, fracture toughness, thermal conductivity, thermal residual stresses, and frictional wear. Our results show that the squeeze cast composite exhibits superior properties to those obtained using powder metallurgy.
相似文献8.
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Justyna Popi Agnieszka Gunia-Krzyak Karolina Soczyska Paulina Koczurkiewicz-Adamczyk Kamil Piska Katarzyna Wjcik-Pszczoa Dorota elaszczyk Anna Krupa Pawe mudzki Henryk Marona Elbieta Pkala 《International journal of molecular sciences》2021,22(1)
Excessive UV exposure contributes to several pathological conditions like skin burns, erythema, premature skin aging, photodermatoses, immunosuppression, and skin carcinogenesis. Effective protection from UV radiation may be achieved with the use of sunscreens containing UV filters. Currently used UV filters are characterized by some limitations including systemic absorption, endocrine disruption, skin allergy induction, and cytotoxicity. In the research centers all over the world new molecules are developed to improve the safety, photostability, solubility, and absorption profile of new derivatives. In our study, we designed and synthesized seventeen novel molecules by combining in the structures two chromophores: xanthone and (E)-cinnamoyl moiety. The ultraviolet spectroscopic properties of the tested compounds were confirmed in chloroform solutions. They acted as UVB or UVA/UVB absorbers. The most promising compound 9 (6-methoxy-9-oxo-9H-xanthen-2-yl)methyl (E)-3-(2,4-dimethoxyphenyl)acrylate) absorbed UV radiation in the range 290–369 nm. Its photoprotective activity and functional photostability were further evaluated after wet milling and incorporation in the cream base. This tested formulation with compound 9 possessed very beneficial UV protection parameters (SPFin vitro of 19.69 ± 0.46 and UVA PF of 12.64 ± 0.32) which were similar as broad-spectrum UV filter tris-biphenyl triazine. Additionally, compound 9 was characterized by high values of critical wavelength (381 nm) and UVA/UVB ratio (0.830) thus it was a good candidate for broad-spectrum UV filter and it might protect skin against UVA-induced photoaging. Compound 9 were also shown to be photostable, non-cytotoxic at concentrations up to 50 µM when tested on five cell lines, and non-mutagenic in Ames test. It also possessed no estrogenic activity, according to the results of MCF-7 breast cancer model. Additionally, its favorable lipophilicity (miLogP = 5.62) does not predispose it to penetrate across the skin after topical application. 相似文献
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