CFD Process Modeling of the Industrial Calcination of Diatomite

Calcination of diatomite is an expensive process frequently resulting in products with unpredictable structure. Alternatively, calcination in swirling flow is an energy‐saving option. Computational fluid dynamics modeling of an experimental calcination process unit is presented. Experimental results and systematic collection of process data were used to define boundary condition for steady‐state and transient simulation runs. The comparison of experimental and simulation results shows the complexity of the calcination process. The results can be used for further process optimization.     

Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma

Comprehensive scientific data provide evidence that isolated phytochemicals or whole plant foods may beneficially modify carcinogenesis. The aim of this study was to evaluate the oncostatic activities of Rhus coriaria L. (sumac) using animal models (rat and mouse), and cell lines of breast carcinoma. R. coriaria (as a powder) was administered through the diet at two concentrations (low dose: 0.1% (w/w) and high dose: 1 % (w/w)) for the duration of the experiment in a syngeneic 4T1 mouse and chemically-induced rat mammary carcinoma models. After autopsy, histopathological and molecular analyses of tumor samples in rodents were performed. Moreover, in vitro analyses using MCF-7 and MDA-MB-231 cells were conducted. The dominant metabolites present in tested R. coriaria methanolic extract were glycosides of gallic acid (possible gallotannins). In the mouse model, R. coriaria at a higher dose (1%) significantly decreased tumor volume by 27% when compared to controls. In addition, treated tumors showed significant dose-dependent decrease in mitotic activity index by 36.5% and 51% in comparison with the control group. In the chemoprevention study using rats, R. coriaria at a higher dose significantly reduced the tumor incidence by 20% and in lower dose non-significantly reduced tumor frequency by 29% when compared to controls. Evaluations of the mechanism of oncostatic action using valid clinical markers demonstrated several positive alterations in rat tumor cells after the treatment with R. coriaria. In this regard, histopathological analysis of treated tumor specimens showed robust dose-dependent decrease in the ratio of high-/low-grade carcinomas by 66% and 73% compared to controls. In treated rat carcinomas, we found significant caspase-3, Bax, and Bax/Bcl-2 expression increases; on the other side, a significant down-regulation of Bcl-2, Ki67, CD24, ALDH1, and EpCam expressions and MDA levels. When compared to control specimens, evaluation of epigenetic alterations in rat tumor cells in vivo showed significant dose-dependent decrease in lysine methylation status of H3K4m3 and H3K9m3 and dose-dependent increase in lysine acetylation in H4K16ac levels (H4K20m3 was not changed) in treated groups. However, only in lower dose of sumac were significant decreases in the expression of oncogenic miR210 and increase of tumor-suppressive miR145 (miR21, miR22, and miR155 were not changed) observed. Finally, only in lower sumac dose, significant decreases in methylation status of three out of five gene promoters–ATM, PTEN, and TIMP3 (PITX2 and RASSF1 promoters were not changed). In vitro evaluations using methanolic extract of R. coriaria showed significant anticancer efficacy in MCF-7 and MDA-MB-231 cells (using Resazurin, cell cycle, annexin V/PI, caspase-3/7, Bcl-2, PARP, and mitochondrial membrane potential analyses). In conclusion, sumac demonstrated significant oncostatic activities in rodent models of breast carcinoma that were validated by mechanistic studies in vivo and in vitro.     

Artificial shortage of surface water: how can water demand management mitigate the scarcity problem?

Water demand management stresses the crucial roles of water user motivations in balancing actual water availability and competing human needs. This paper shows how the absence of such motivations influences artificial water scarcity, even in resource‐abundant countries, and how slight modifications to economic instruments (surface water charges in particular) might solve the problem. Data from the Czech Republic are used to illustrate the rationale behind the artificial scarcity problem and its solution. A model with feedback based on historical surface water abstraction data is built to simulate the impacts of different payment modification scenarios.     

Laparoscopic surgery in esophageal achalasia--initial results

The authors present their initial results of laparoscopic operations on account of achalasia of the oesophagus. The first oesophagocardiomyotomy was performed at the author s department by the laparoscopic approach in September 1994. In the course of one year 20 of these operations were performed. The mean period of complaints before surgery was 5.9 years with a range of 1 to 40 years. Only six patients were operated during the stage of compensated achalasia, the remainder already in the stage of decompensation. As to peroperative complications twice perforation of the oesophagus occurred, in one instance treated laparoscopically and once during conversion by the classical approach. In one instance the a. epigastrica was injured and haemoperitoneum developed and subsequent revision was urgent. All patients were relieved of their dysphagic complaints, one female patient developed minor pyrosis.     

Economic Assessment of the Hydrogenation of CO2 to Liquid Fuels and Petrochemical Feedstock

To remove high concentrations of CO₂ from the off‐gas of coal‐driven power plants, a new process was proposed. The catalytic hydrogenation of the CO₂ leads to the production of C₂ – C₄ (petrochemical feedstock) and liquid C₅₊ hydrocarbons (fuel). Thus, environmentally harmful CO₂ may be converted sustainably to useful products. On the basis of a process flow sheet, the costs for processing the CO₂ are estimated for different plant sizes. The price of hydrogen contributes significantly to the overall production costs. Further price reductions may be achieved by final engineering optimization of the process as a whole and specific unit operations.     

The knowledge domain of the academy of international business studies (AIB) conferences: a longitudinal scientometric perspective for the years 2006–2011

Conferences play a major role for the development of scientific domains. While journal and article contributions in the field of international business (IB) are a general and well researched area of scientometric studies, conferences are not. The absence of a systematic assessment of international business conferences as a reference to the collective status of the Academy of International Business (AIB) community is astonishing. Whatever reasons are accountable for that fact, this paper starts to fill that gap. It establishes a knowledge network composed of the last six years AIB conferences. We collected all the contributions in full text with their abstracts and keywords from 2006 to 2011. All the data have been organized in a data system and we used the information-theoretic clustering method which allows different analytical views through the entire knowledge corpus. The results indicate significant statistical differences between topic modules and keyword threads of the yearly conferences. There are three keywords which dominate as a leitmotif between 2006 and 2011, but the detailed structure changes from conference to conference significantly.