Profiling hot isostatically pressed canister–wasteform interaction for Pu-bearing zirconolite-rich wasteforms

Zirconolite-rich full ceramic wasteforms designed to immobilize Pu-bearing wastes were produced via hot isostatic pressing (HIP) using stainless steel (SS) and nickel (Ni) HIP canisters. A detailed profiling of the elemental compositions of the major and minor phases over the canister–wasteform interaction zone was performed using scanning electron microscopy combined with energy-dispersive X-ray spectroscopy (SEM-EDS) characterization. Bulk sample analyses from regions near the center of the HIP canister were also conducted for both samples using X-ray diffraction and SEM-EDS. The sample with the Ni HIP canister showed almost no interaction zone with only minor diffusion of Ni from the inner wall of the canister into the near-surface region of the wasteform. The sample with the SS HIP canister showed ∼100–120 μm of interaction zone dominated by high-temperature Cr diffusion from canister materials to the wasteform with the Cr predominantly incorporated into the durable zirconolite phase. We also examined, for the first time, changes to the HIP canister wall thickness caused by HIPing and demonstrated that no canister wall thinning occurred. Instead, in the areas examined, the canister wall thickness was observed to increase (up to ∼20%) due to the compression occurring during the HIP cycle. Further, only sparse formation of (Cr, Mn)-rich oxide particles were noted within the HIP canister inner wall area immediately adjacent to the ceramic material, with no evidence for reverse diffusion of ceramic materials. Though the HIP canister–wasteform interaction extends to ∼120 μm when using an SS HIP canister for the system investigated, this translates to <<1 vol.% for an industrial scale HIPed wasteform. Importantly, the HIP canister–wasteform interactions did not produce any obviously less durable phases in the wasteform or had any detrimental impact on the HIP canister properties.     

The Role of Cholesterol on Triterpenoid Saponin-Induced Endolysosomal Escape of a Saporin-Based Immunotoxin

Cholesterol seems to play a central role in the augmentation of saporin-based immunotoxin (IT) cytotoxicity by triterpenoid saponins. Endolysosomal escape has been proposed as one mechanism for the saponin-mediated enhancement of targeted toxins. We investigated the effects of lipid depletion followed by repletion on Saponinum album (SA)-induced endolysosomal escape of Alexa Fluor labelled saporin and the saporin-based immunotoxin OKT10-SAP, directed against CD38, in Daudi lymphoma cells. Lipid deprived cells showed reduced SA-induced endolysosomal escape at two concentrations of SA, as determined by a flow cytometric method. The repletion of membrane cholesterol by low density lipoprotein (LDL) restored SA-induced endolysosomal escape at a concentration of 5 µg/mL SA but not at 1 µg/mL SA. When LDL was used to restore the cholesterol levels in lipid deprived cells, the SA augmentation of OKT10-SAP cytotoxicity was partially restored at 1 µg/mL SA and fully restored at 5 µg/mL SA. These results suggest that different mechanisms of action might be involved for the two different concentrations of SA and that endosomal escape may not be the main mechanism for the augmentation of saporin IT cytotoxicity by SA at the sub-lytic concentration of 1 µg/mL SA.     

Overheating and passive habitability: indoor health and heat indices

As extreme heat and weather events are predicted to increase due to global warming, the risk of human heat stress within buildings will increase. To be resilient, buildings will need the capacity to provide habitable indoor conditions without power for limited amounts of time. Additional indoor thermal standards are required for public health to address ‘passive habitability’ during power outages. Current research on building-related heat stress and numerous heat indices is examined in relation to the development of a new heat-safety metric for use in passively conditioned buildings. Most indoor overheating research relies on outdoor temperature data and has no common indoor heat index for evaluating indoor heat stress. A recommendation is made for using the wet-bulb globe temperature (WBGT) and predicted heat strain (PHS) indices for modelling and monitoring of indoor heat stress in healthy adult populations because both indices utilize the primary thermoregulation variables, have associated heat-stress thresholds, and can be assessed or tracked with existing environmental monitoring methods and predictive energy modelling techniques. Further research is recommended on health effects and exposure limits of vulnerable populations, and the variation in thermal factors within buildings and the building stock.     

What scope for integrating land management policies,land administration processes and data infrastructures for housing production in Nigeria?

Existing knowledge reveals that land as a resource is not currently managed efficiently and effectively in most countries of the world. One of the factors considered important in understanding the inefficiencies and ineffectiveness is the level of integration between agencies. The objective of this paper is to determine the level of this inefficiency in order to improve our understanding of the inter-relationship between agencies that perform land administration functions. The research methods include a synthesis of past studies and the use of case study approach. It uses as context, Lagos, in Nigeria. This approach involves a mixed method: interviews and online survey. The results revealed limited integration of processes and collaboration of agencies in the management of land for housing production. We conclude that policies are not sufficiently informed by data and there is a noticeable disconnection between agencies, and formulated policies.     

Compliant activity rather than difficulty accelerates thought probe responsiveness and inhibits deliberate mind wandering

ABSTRACT

Mind wandering is a commonly intruding cognitive state that leads to diminished performance and increased error risk during a primary task. A controversy over whether easier or more difficult tasks increase mind wandering has led to mind wandering being proposed as two different states: deliberate and spontaneous. We hypothesise that forced engagement via persistent compliant activity may both increase responsiveness and inhibit non-instrumental activities including deliberate mind wandering. Twenty-eight healthy adults interacted with 2 pairs of stimuli, each pair having one low-interactivity version and a high-interactivity version requiring compliant activity. Mind wandering was assessed by thought probes, and subjective responses were rated using visual analogue scales. Reaction times were measured using Superlab. Compliant activity decreased the prevalence of deliberate mind wandering episodes but not of overall mind wandering. Thought probe durations were accelerated significantly by compliant activity, near-significantly by thinking on-task thoughts, and additively by the combination of both. Deliberate and spontaneous mind wandering elicited equivalent thought probe durations. We conclude that compliant activity works synergistically with lack of mind wandering to accelerate the difficult task of thought probe response but not simple reaction times. These results fit with an arousal model but not the attentional resources model.     

TSTL: the template scripting testing language

International Journal on Software Tools for Technology Transfer - A test harness, in automated test generation, defines the set of valid tests for a system, as well as their correctness properties....