老空间的魅力新生 海牙某历史建筑改造

<正>该建筑坐落在海牙市中心,邻近海牙森林,矗立在Bezuidenhoutseweg大街——一条连接皇家宫殿Huisten Bosch和荷兰国会建筑Het Binnenhof的历史性轴线。这个具有强烈而独特风格的雄伟建筑始建于1917年,由当时的政府首席建筑师DanielE.C. Knuttel设计,为财政紧缩时期的外交部办公所用,1994年由Hans     

Psychological interventions for arthritis pain management in adults: A meta-analysis.

Context: The psychosocial impact of arthritis can be profound. There is growing interest in psychosocial interventions for managing pain and disability in arthritis patients. Objective: This meta-analysis reports on the efficacy of psychosocial interventions for arthritis pain and disability. Data Sources: Articles evaluating psychosocial interventions for arthritis were identified through Cochrane Controlled Trials, EMBASE, Ovid MEDLINE, and Ovid PsycINFO data sources. Study Selection: Randomized controlled trials testing the efficacy of psychosocial interventions in arthritis pain management were reviewed. Data Extraction: Twenty-seven randomized controlled trials were analyzed. Pain intensity was the primary outcome. Secondary outcomes included psychological, physical, and biological functioning. Data Synthesis: An overall effect size of 0.177 (95% CI = 0.256-0.094) indicated that patients receiving psychosocial interventions reported significantly lower pain than patients in control conditions (combined p = .01). Meta-analyses also supported the efficacy of psychosocial interventions for the secondary outcomes. Conclusions: These findings indicate that psychosocial interventions may have significant effects on pain and other outcomes in arthritis patients. Ample evidence for the additional benefit of such interventions over and above that of standard medical care was found. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

重振城市景观的的“乌托邦” 阿尔斯特图书馆和表演艺术学院

<正>阿尔斯特图书馆和表演艺术学院坐落在比利时阿尔斯特,由一栋8000m~2的砖结构建筑和一栋引人注目的 19世纪后期的历史建筑组成。项目的名称为"乌托邦",与托马斯莫尔的著作《乌托邦》同名,这本书是由阿尔斯特市民德克马滕斯首先出版。     

A simple protocol for paraffin-embedded myelin sheath staining with osmium tetroxide for light microscope observation

Experimental investigation of peripheral nerve fiber regeneration is attracting more and more attention among both basic and clinical researchers. Assessment of myelinated nerve fiber morphology is a pillar of peripheral nerve regeneration research. The gold standard for light microscopic imaging of myelinated nerve fibers is toluidine blue staining of resin-embedded semithin sections. However, many researchers are unaware that the dark staining of myelin sheaths typically produced by this procedure is due to osmium tetroxide postfixation and not due to toluidine blue. In this article, we describe a simple pre-embedding protocol for staining myelin sheaths in paraffin-embedded nerve specimens using osmium tetroxide. The method involves immersing the specimen in 2% osmium tetroxide for 2 h after paraformaldehyde fixation, followed by routine dehydration and paraffin embedding. Sections can then be observed directly under the microscope or counterstained using routine histological methods. Particularly good results were obtained with Masson's trichrome counterstain, which permits the imaging of connective structures in nerves that are not detectable in toluidine blue-stained resin sections. Finally, we describe a simple protocol for osmium etching of sections, which makes further immunohistochemical analysis possible on the same specimens. Taken together, our results suggest that the protocol described in this article is a valid alternative to the conventional resin embedding-based protocol: it is much cheaper, can be adopted by any histological laboratory, and allows immunohistochemical analysis to be conducted.     

Response to Knittle.

Responds to comments by K. P. Knittle (see record 2009-14439-017) on the authors' original article (see record 2007-06671-001) regarding the effect sizes they presented in their meta-analysis of psychological interventions for arthritis pain management. After conducting a re-analysis and reporting the results, the authors conclude that the findings still support their original conclusions with regard to the fact that psychosocial interventions can produce modest, but significant effects on pain that are within the range reported for other disease-related and chronic pain conditions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Daily Mood and Stress Predict Pain, Health Care Use, and Work Activity in African American Adults With Sickle-Cell Disease.

This study examined the extent to which daily mood and stress were associated with pain, health care use, and work activity in 41 adults (mean age=36 years) with sickle-cell disease. Multilevel model analyses of daily diaries (M=91 days) indicated that increases in stress and negative mood were associated with increases in same-day pain, health care use, and work absences. Lagged models suggested bidirectional relationships, with evidence that pain may be the more powerful initiating variable in pain-mood and pain-stress cycles. Of importance, positive mood was associated with lower same-day and subsequent day pain, as well as fewer health care contacts, suggesting that positive mood may serve to offset negative consequences of pain and other illness symptoms. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A comparison of human prothrombin, factor IX (Christmas factor), factor X (Stuart factor), and protein S

Human prothrombin, factor IX, and factor X have been idolated in high yield and characterized as the their amino-terminal sequence, molecular weight, amino acid composition, and migration in sodium dodecyl sulfate-polyacrylamide gel electrophoresis. An additional human plasma protein, called protein S, has also been purified and its properties have been compared with those of prothrombin, factor IX, and factor X. Prothrombin (mol wt 72 000), factor IX (mol wt 57 000), and protein S (mol wt 69 000) are single-chain glycoproteins, while factor X (mol wt 59 000) is a glycoprotein composed of two polypeptide chains held together by a disulfide bond(s). The amino-terminal sequence of the light chain of human factor X is homologous with prothrombin, factor IX, and protein S. The heavy chain of human factor X is slightly larger than the heavy chain of bovine factor X and differs from bovine factor X in its amino-terminal sequence.     

Symptom changes and self-esteem as correlates of positive conditioning of grooming in hospitalized psychotics.

Evaluated a behavior modification program aimed at improving grooming behaviors with regard to changes in self-esteem and ward behavior. 27 unselected, institutionalized psychotics were rated on a self-esteem interview scale and the Psychotic Reaction Profile (PRP) before and after experimental Ss (n = 14) received behavior modification. After treatment, experimental Ss displayed significantly higher scores on verbal expression of self-esteem, which related to feelings of attractiveness, and had significantly lower scores on the PRP Paranoid Belligerence scale than controls. Results suggest that improvement in affective states, particularly as reported by the patient, should be considered when implementing behavioral programs dealing with the performance of self-care and grooming behaviors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Urodynamics in children. Part I. Methodology

We evaluated 237 children for various disorders in the urodynamic laboratory. A total of 334 studies was done, using a 6-channel recorder combined with a portable fluoroscopic unit. Simultaneous recordings of intravesical pressure, intra-abdominal pressure, urine flow rate, external urethral electromyography and cystourethrography were obtained during bladder filling and voiding. These objective tests have provided us with an insight into the nature of a variety of voiding dysfunctions in children. Details of the methods used for urodynamic testing in these children are outlined and compared to other methods that have been proposed.