Nature and etiology of hollow-organ abdominal injuries in frontal crashes

Injuries to the hollow organs of the lower digestive system carry substantial risk of complication due to infection and blood loss, and commonly require invasive abdominal surgery to diagnose and treat. The causes of, and risk factors for, lower abdomen injury in automobile collisions are poorly understood. The goal of this study was to investigate the risk factors and potential mechanisms of hollow-organ, lower abdomen injury in belted automobile occupants in frontal collisions.     

Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors

The 2-oxoglutarate-dependent hypoxia inducible factor prolyl hydroxylases (PHDs) are targets for treatment of a variety of diseases including anaemia. One PHD inhibitor is approved for use for the treatment of renal anaemia and others are in late stage clinical trials. The number of reported templates for PHD inhibition is limited. We report structure–activity relationship and crystallographic studies on a promising class of 4-hydroxypyrimidine-containing PHD inhibitors.     

开闭屋顶结构及其驱动控制形式的综合分析

开闭屋顶可以给人们带来室内、室外两种感觉,并且比赛时不用再考虑受天气因素的影响。活动屋顶是一种不同于传统结构的高难度工程,是建筑与机械的完美结合,开闭的形式各有不同。本文以世界上典型的开闭屋顶为例分析驱动控制机理,讨论各种形式的优劣。     

Edge of Empire: transnationalism and identity in Wellington, New Zealand, ca . 1860- ca . 1920

Aspects of transnationalism and identity in the period from the 1860s to the mid 1920s, which set in motion a form of globalization related to empire, are focused upon. The notion of 'regimes of representation' is adapted as a broad conceptual framework for exploring the role of colonial directories in establishing the identity of metropolitan commercial culture in Wellington, New Zealand. This outpost of empire is examined through a detailed analysis of the images presented in a series of directories by Kelly's and Wise. These reveal how British commerce established a strong and lasting identity in the colony through a variety of 'acts of representation'. It is concluded that colonial directories are a worthwhile but neglected source for exploring the geographies of empire.     

The bacterial population of piggery-waste anaerobic digesters

A survey was made of the anaerobic and facultatively anaerobic bacteria present in piggery waste, digesting piggery waste and domestic anaerobic sludge sludge used to start a piggery waste digester. An influence of the input waste was shown in that streptococci, the predominant facultatively anaerobic bacteria in the piggery waste, were the predominant bacteria in the digesting waste, and they replaced Enterobacter, predominant in the domestic sludge, when a piggery waste digestion had been established from this latter material. Cellulolytic or methanogenic bacteria could not be detected in the piggery waste but populations of these, and other hydrolytic bacteria, became established at different times during the buildup of digestion by gradual addition of piggery waste to water. The bacteria concerned in degradation of the waste constituents were all anaerobes.Production of methane from H₂/CO₂, formate and butyrate could be detected in mixed cultures from dilutions of digester contents, but the only methanogenic bacterium that could be isolated in pure culture was Methanobacterium formicicum, which uses H₂/CO₂ or formate only.     

Reconceptualising territoriality and spatial planning: insights from the sea

The concept of territoriality and its relationship to the focus and substance of spatial planning is the subject of much interest at the present time and this paper seeks to contribute to the debate by stepping into the sea. The first part of the paper establishes a framework for considering the spatial planning implications of changing conceptions of territoriality, outlining key sources of territorial innovation and their implications in terms of the development of new units and styles of governance, new challenges for planning practice, and the potential for feedback informing the development of planning theory. The application of the framework is then illustrated in the second part of the paper with reference to the emerging field of maritime spatial planning and in particular to the pioneering work that is being undertaken in Europe. This work is testing established notions of territoriality by highlighting the strong and growing connections between the land and the sea. Here some of the key implications for future spatial planning practice are identified. These indicate that there is a growing recognition of the need for innovation in the territorial units of governance in maritime regions and in the themes, processes and methods of spatial planning in these areas. The paper concludes with some observations on the implications of these findings for the theory of spatial planning.     

Building dampness diagnosing the causes

In our January/February issue last year, Jim Smith described the insights he had gained as the human expert being ‘mined’ by the knowledge engineers for an expert system to aid diagnosis of the causes of dampness in buildings. An overview of that BREDAMP project is presented here, explaining the background to the project and its objectives, and the way the expert system was created, discussing in detail the methods used to capture the depth of knowledge available.     

Earthquake-induced net section fracture in brace connections — experiments and simulations

Results from six tests, finite element simulations and a synthesis of previous test programs on slotted end bracing connections are presented. The main objective of the research is to examine the deformation capacity of these connections, with the ultimate objective of minimizing the requirement for net section reinforcement that is often inconvenient from the perspective of fabrication. The experiments and simulations feature commonly used pipe specimens and end details. The main parameters investigated include the gusset plate thickness, the slot length and introduction of a wrap-around weld that eliminates the reduced section at the edge of the gusset plate. The results indicate that even without reinforcement, the connections offer adequate to excellent deformation capacity if they are provided with the wrap-around weld or if the net section strength is larger than the gross yield strength. This may be achieved in situations where shear lag in the connection is minimal, and where the area reduction due to the slot is small relative to the gross area. Design considerations are presented along with limitations of the study.     

An analytical solution to the extended Navier–Stokes equations using the Lambert W function

Microchannel gas flows are of importance in a wide range of microelectro mechanical devices. In these flows, the mean free path of the gas can be comparable to the characteristic length of the microchannel, leading to strong diffusion‐enhanced transport of momentum. Numerical solutions to the extended Navier–Stokes equations (ENSE) have successfully modeled such microchannel flows. Analytical solutions to the ENSE for the pressure and velocity fields using the Lambert W function are derived. We find that diffusive contributions to the total transport are only dominant for low average pressures and low pressure drops across the microchannel. For large inlet pressures, we show that the expressions involving the Lambert W function predict steep gradients in the pressure and velocity localized near the channel exit. We extract a characteristic length for this boundary layer. Our analytical results are validated by numerical and experimental results available in the literature. © 2014 American Institute of Chemical Engineers AIChE J, 60: 1413–1423, 2014