可持续理念的体现——杭州来福士中心

正UNStudio由Ben van Berkel和Caroline Bos创立,是一个国际性的建筑设计网络。拥有三个全方位服务的国际事务所,分别位于阿姆斯特丹、香港和上海。专于建筑、室内建筑、产品设计、城市发展和基础设施项目。地址:浙江省杭州市钱江新城富春路业主方:凯德集团建筑面积:392526m~2项目年份:2017醒目的裙楼之上坐落着两座流线型的高楼,从中可以饱览钱塘江和西湖的迷人风光。     

Obesity as a prospective predictor of depression in adolescent females.

Objective: Both obesity and depression are prominent during adolescence, and it is possible that obesity is a trigger for adolescent depression. The purpose of this paper is to evaluate whether overweight or obese status contributes to the development of depression in adolescent girls. Design: Participants were 496 adolescent girls who completed interview based measures of depression and had their height and weight measured at four yearly assessments. Repeated measures logistic regressions with generalized estimating equations were used to evaluate whether overweight or obese status were associated with major depression or an increase in depressive symptoms the following year. Main Outcome Measures: Major depression and depressive symptoms were evaluating using a modified version of the K-SADS interview. Overweight and obese status was determined by using standardized protocols to measure height and weight. Results: Results showed that obese status, not overweight status, was associated with future depressive symptoms, but not major depression. This study demonstrated that obesity is a risk factor for depressive symptoms, but not for clinical depression. Conclusions: As depressive symptoms are considered along the spectrum of depression with clinical depression at the high end, these results suggest that weight status could be considered a factor along the pathway of development of depression in some adolescent females. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Prior treatment received by patients with bulimia nervosa

The purpose of this study was to investigate and compare the effects of paclitaxel and its water-soluble conjugates (sodium-pentetic acid-paclitaxel; polyethylene glycol-paclitaxel, and poly[L-glutamic acid]-paclitaxel) on chromosome morphology and induction of apoptosis in a metastatic murine melanoma cell line (K1735 clone X-21). For this, murine melanoma cells were treated continuously for 72 h with three concentrations (1.2 microM, 2.4 microM, and 4.8 microM) of each of paclitaxel, and conjugates. Another set of cells were pulse-treated at 2.4 microM, 4.8 microM and 9.6 microM concentrations of each of these drugs for 4 h and the recovered cells were examined after 72 h. Control cultures received only the solvents (dimethyl sulfoxide or water). Our results showed a significant increase in the frequencies of telomeric associations, chromosome aberrations, polyploidization, distorted and disintegrated chromosome morphology, and reduced telomeric signal intensity by fluorescence in situ hybridization, in treated cultures as compared to the controls. However, we detected no change in telomerase activity. In addition, the majority of interphase nuclei in treated cells showed apoptotic bodies, with chromatin condensation. These in vitro results suggest that cell death induced by paclitaxel and its water-soluble conjugates is due to the loss of telomeric repeats, as shown by reduced signal flourescence and increased telomeric associations.     

11—THE DRYING OF TEXTILE FABRICS. PART II: THE RELATIONSHIP BETWEEN AIR-MOISTURE CONTENT AND FABRIC TEMPERATURE

The measurement of fabric temperatures by contact methods during drying is shown to give an unreliable estimate of the moisture content of the air in equilibrium with the fabric because the contacting device behaves as an improperly wetted wet bulb. Automatic control systems depending on such measurement to regulate drying in a tenter are therefore unsatisfactory.     

杭州来福士中心

正项目名称:杭州来福士中心建设地点:中国浙江省杭州市设计单位:UNStudio合作单位:中国联合工程公司用地面积:40 355 m 建筑面积:392 526 m 建筑层数:3(下),60(上)设计总负责:Ben van Berkel建筑专业:Hannes Pfau,Astrid Piber结构专业:Arup上海设备专业:Arup上海景观设计:TOPO设计集团. LLC,上海设计时间:2008年     

Technological and flavour potential of cultures isolated from traditional Greek cheeses – A pool of novel species and starters

This study explored the microbiota of Formaella, Kopanisti, Feta and Mana cheeses. A total of 133 wild lactic acid bacteria were isolated and classified phenotypically. Mesophilic lactobacilli were the most abundant group. Thermophilic lactobacilli and thermophilic cocci were the best milk acidifiers, whereas thermophilic lactobacilli were the most proteolytic isolates. Higher peptidolytic and esterolytic activities were obtained with thermophilic cocci. Only five isolates were lipolytic, whereas none was able to catabolize citrate. Fast gas chromatography−mass spectrometry analysis of the metabolites produced and subsequent principal components analysis revealed segregated groups of isolates in accordance with the phenotypic ones. Electronic nose analysis revealed similar results. Lactobacillus rennini and Lactobacillus acidipiscis were found to be the sole microbial species in Kopanisti cheese and Mana. These isolates produced alcohols and aldehydes as major volatile compounds, as a result of secondary amino acid catabolism.     

The potential of dairy lactic acid bacteria to metabolise amino acids via non-transaminating reactions and endogenous transamination

The metabolism of amino acids by 22 starter and 49 non-starter lactic acid bacteria (LAB) was studied in a system consisting of amino acids and non-growing cells without added amino acceptors such as alpha-ketoglutarate. There were significant inter- and intra-species differences in the metabolism of amino acids. Some amino acids such as alanine, arginine, aspartate, serine and branched-chain amino acids (leucine, isoleucine and valine) were utilised, whereas other amino acids such as glycine, ornithine and citrulline were produced. Alanine and aspartate were utilised by some LAB and accumulated during the incubation of other LAB. Arginine was degraded not only by Lactococcus lactis subsp. lactis (the lactococcal subspecies known to catabolise arginine), but also by pediococci, heterofermentative lactobacilli (Lactobacillus brevis and Lb. fermentum) and some unidentified homofermentative lactobacilli. Serine was utilised predominantly by homofermentative Lb. paracasei subsp. paracasei, Lb. rhamnosus and Lb. plantarum. Of the LAB studied, Lb. brevis and Lb. fermentum were the most metabolically active, utilising alanine, arginine, aspartate, glutamate and branched-chain amino acids. Leuconostocs were the least metabolically active, showing little potential to metabolise amino acids. The formation of ammonia and acetate from amino acid metabolism varied both between species and between strains within species. These findings suggest that the potential of LAB for amino acid metabolism via non-transaminating reactions and endogenous transamination will impact both on the physiology of LAB and on cheese ripening, especially when transamination is rate-limiting in the absence of an exogenous amino acceptor such as alpha-ketoglutarate.     

Scenarios for offshore wind power production for Central California Call Areas

In response to the growing interest in offshore wind energy development in California, the U.S. Bureau of Ocean Energy Management delineated three Call Areas for potential leasing. This study provides a comprehensive characterization and comparison of offshore wind power potential within the two Central California Call Areas (Diablo Canyon and Morro Bay) using 12- and 15-MW turbines under different inter-turbine spacing and wind farm size scenarios. Our analysis shows similar daily and seasonal patterns of wind power produced within the Call Areas, which peak in spring and during evening hours. Per-turbine power production is higher in the Morro Bay Call Area due to slightly higher hub-height wind speeds, whereas total power production is higher in the Diablo Canyon Call Area due to its larger size. Turbine type had a negligible impact on average power production per-unit-area because while larger turbines produce more power, they require greater inter-turbine spacing. Combined power production from the two fully built out Call Areas could equal nearly a quarter of California's current annual electrical energy production. A commercial-scale wind farm with a realized power output of 960 MW would require a footprint of at least half of the Morro Bay Call Area or at least a quarter of the Diablo Canyon Call Area. These results provide guidance on offshore wind development over the Central California Coast, and the framework demonstrated here could be applied to other wind data sets in other regions.     

An observation system simulation experiment for the impact of landsurface heterogeneity on AMSR-E soil moisture retrieval

Using a high-resolution hydrologic model, a land surface microwave emission model (LSMEM), and an explicit simulation of the orbital and scanning characteristics for the advanced microwave sensing radiometer (AMSR-E), an observing system simulation experiment (OSSE) is carried out to assess the impact of land surface heterogeneity on large-scale retrieval and validation of soil moisture products over the U.S. Southern Great Plains using the 6.925 GHz channel on the AMSR-E sensor. Land surface heterogeneity impacts soil moisture products through the presence of nonlinearities in processes represented by the LSMEM, as well as the fundamental inconsistency in spatial scale between gridded soil moisture imagery derived from in situ point-scale sampling, numerical modeling, and microwave remote sensing sources. Results within the 575000 km² Red-Arkansas River basin show that, for surfaces with vegetation water contents below 0.75 kg/m², these two scale effects induce root mean squared errors (RMSEs) of 1.7% volumetric (0.017 cm_water³/cm_soil³ ) into daily 60 km AMSR-E soil moisture products and RMS differences of 3.0% (0.030 cm_water/3cm_soil³ ) into 60 km comparisons of AMSR-E soil moisture products and in situ field-scale measurements of soil moisture sampled on a fixed 25-km grid     

The diversity of potential cheese ripening characteristics of lactic acid starter bacteria: 1. Resistance to cell lysis and levels and cellular distribution of proteinase activities

By reference to subcellular fraction markers, the resistance to lysis of 23 strains of Lactococcus lactis subsp. cremoris, 30 strains of L. lactis subsp. lactis and five strains of Streptococcus thermophilus and the levels and distribution of proteinase activity in the strains were determined. Strains of L. lactis subsp. cremoris were readily lysed by transfer to hypotonic buffer after treatment with lysozyme alone, whilst strains of L. lactis subsp. lactis and S. thermophilus could be efficiently lysed in this way only after treatment with a combination of lysozyme and mutanolysin. With a few notable exceptions, those strains which gave the fastest rates of acid production also generally presented higher levels of cell surface proteinase, as determined by activity on fluorescein isothiocyanate-labelled β-casein. The highest levels of cell surface proteinase detected were found for strains of L. lactis subsp. cremoris. However, the levels of total proteinase activity in the lactococcal strains did not correlate with the rate of acid production in milk, some slow acid-producers yielding similar or greater total proteinase levels than fast acid-producers. Homology to DNA probes for the lactococcal cell surface proteinase gene and to the conserved region encoding the serine proteinase active site was shown by the fast acid-producing lactococcal strains, but not by most of the slow acid-producing lactococcal strains or by the strains of S. thermophilus. A significant proportion of the total proteinase activity was recovered in the subcellular fractions in which high levels of cytoplasmic marker enzyme activity were found. The total proteinase levels detected in strains ofL. lactis subsp. lactis showed a greater range of variation than in the strains of L. lactis subsp. cremoris. High levels of total proteinase activity were found in the slow acid-producers despite the strains having been grown in the presence of yeast extract. For many of the strains, the levels of proteinase released from the cell surface during cell wall degradation with lytic enzyme treatment were higher than those found using whole cells, suggesting that a significant amount of proteolytic activity was either inaccessible to substrate or present in an inactive form.