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Low molecular weight β-glucan stimulates doxorubicin-induced suppression of immune functions in mice
Nak-Yun Sung Eui-Baek Byun Du-Sup Song Young-Choon Yoo Jae-Kyung Kim Jong-Heum Park Beom-Seok Song Sang-Hyun Park Ju-Woon Lee Young-Beob Yu Jae-Hun Kim 《Food science and biotechnology》2012,21(3):645-651
The aim of this study was to evaluate the protective effect of low molecular weight β-glucan (LMG) against doxorubicin (DOX)-induced immune suppression of tumor-bearing mice. The tumor size and spleen cell functions such as spleen cell proliferation, cytokine production (interferon-γ and interleukin-2), and the population of CD4+ and CD8+ T cells were estimated. In the tumorbearing mice, the tumor size was significantly (p<0.05) decreased by DOX treatment. However, there was no significant difference between mice treated with high molecular weight β-glucan (HMG) and mice treated with LMG. Spleen cell proliferation and cytokine production were significantly (p<0.05) decreased in only DOX treated group, but increased in all β-glucan treated groups with DOX. Moreover, the populations of CD4+ and CD8+ T cells were also increased in the LMG-treated group. It appears that LMG effectively reduces the DOX-induced immune toxicity through activation of immune cells such as splenocytes. 相似文献
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Sung Nak-Yun Choi Jong-il Yoon Yohan Lee Soo-Young Byun Myung-Woo Hwang Yeoung-Jung Koenari Zubaidah Irawati Lee Ju-Woon Kim Jae-Hun 《Food science and biotechnology》2011,20(3):841-844
This study evaluated the anti-allergic effect of low molecular weight β-glucan (25 kDa) degraded by λ-irradiation. Allergy
was induced in mouse models administrated with λ-irradiated low molecular weight and non-irradiated high molecular weight
β-glucan, respectively, for 7 days. However, only the mice treated with low molecular weight β-glucan had a significantly
decreased the total serum IgE and ovalbumin specific-IgE levels, and significantly increased Th 1 cytokine expression compared
to only allergy induced mice. The allergic responses could be reduced by low molecular weight β-glucan treated λ-irradiation
through the increased expression of Th 1 response and decreased expression of total IgE and antigen specific IgE. 相似文献
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Kim Dae-Hyung Sung Nak-Yun Kim Jeong-Soo Kim Jae-Hun Hwang Yeoung-Jung Lee Ju-Woon 《Food science and biotechnology》2011,20(5):1337-1345
The objective of this study was to evaluate the alcohol-metabolizing and antioxidative activities of complex herbal extract
(CHE). The alcohol-metabolizing activity of CHE was evaluated by assessing alcohol dehydrogenase (ADH) activity, acetaldehyde
dehydrogenase (ALDH) activity, and protective effect against alcohol induced damage in in vitro and in vivo models. In this study, CHE treatment significantly increased ADH and ALDH activities and reduced cell death in alcohol-induced
liver cell damage. Moreover, it also significantly reduced the serum alcohol and acetaldehyde concentrations in alcoholfed
rats. To define the effect of CHE on alcohol metabolism, its antioxidative activities were estimated by measuring radical
scavenging activity, ferric-reducing antioxidant potential ability, and thiobarbituric acid reactive substance, and the results
demonstrated a higher antioxidative capacity of CHE than the vitamin C control at a high dose (10 mg/mL). Therefore, this
study suggests that CHE can be a potential natural resource for the management of ethanol-induced liver toxicity. 相似文献
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Jeon Taeil Hwang Seong-gu Jung Yeon-Hwa Hyo-Seon Yang Sung Nak-Yun Lee Junglim Park Dong Ki Yoo Yung-Choon 《Food science and biotechnology》2011,20(1):209-214
Here, the effect of oral administration of the extract of sangwhang mushroom (Phellinus linteus, PL) grown on germinated brown rice on lung metastasis of tumor cells was examined in mice, and a possible immunological
action was suggested. Oral administration of the extract of sangwhang mushroom grown on germinated brown rice (PB, 90 mg/kg) prior to tumor inoculation significantly inhibited experimental lung
metastasis produced by colon 26-M3.1 carcinoma cells. Also oral administration of PB after tumor inoculation significantly
inhibited experimental lung metastasis of tumor cells. In addition, oral administration of PB significantly suppressed tumor
growth as well as tumor-induced angiogenesis. However, neither PL nor germinated brown rice (BR) was active. Oral administration
of PB, but not PL and BR, resulted in a significant enhancement of natural killer (NK)-mediated killing activity against tumor
cells. These results suggest that oral administration of PB can induce antitumor activity to inhibit tumor metastasis, and
its antitumor effect is associated with NK cell activation. 相似文献
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Min-Ji Kim Koth-Bong-Woo-Ri Kim Nak-Yun Sung Eui-Hong Byun Hee-Sup Nam Dong-Hyun Ahn 《Food science and biotechnology》2018,27(1):131-137
Tuna cooking drip (TCD) is a protein rich by-product of canned tuna processing that is typically discarded. In this study, the immune-enhancing activities of TCD and its enzymatic hydrolysate (EH-TCD) were investigated by intraperitoneally administering Balb/c male mice with TCD and EH-TCD for 2 weeks. This administration resulted in an increase in the weight of the spleen and thymus (200–800 mg/kg) and enhanced the proliferation rates of splenocytes (200–800 mg/kg). TCD and EH-TCD significantly increased the production of immunostimulatory cytokines (interleukin-10 and interleukin-2). In addition, TCD and EH-TCD increased serum IgG1 and IgG2a levels in a concentration-dependent manner. Particularly, EH-TCD had a greater immune-enhancing effect than TCD. These results suggest that TCD and EH-TCD exert immune-enhancing effects through an IgG antibody response and T cell activation, and EH-TCD can be used as an immunostimulatory agent. 相似文献
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