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排序方式: 共有4823条查询结果,搜索用时 15 毫秒
1.
Brito Claúdia Esteves Marisa Peixoto Hugo Abelha António Machado José 《Wireless Networks》2022,28(3):1269-1277
Wireless Networks - Continuous ambulatory peritoneal dialysis (CAPD) is a treatment used by patients in the end-stage of chronic kidney diseases. Those patients need to be monitored using blood... 相似文献
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Rosa Vera Oladis T. de Rincón Jesús Ramirez Bárbara Valverde Andrés Díaz-Gómez Rodrigo Sánchez-González 《工业材料与腐蚀》2020,71(7):1125-1137
In this study, the behavior of carbon steel and galvanized steel in nontropical coastal marine environments was evaluated. Evaluation was carried out with specimens with dimensions of 10 cm × 10 cm × 0.3 cm. These specimens were exposed to four testing stations (Iquique, Mejillones, Los Vilos, and San Vicente), where racks were installed both at ground level (ground), as well as in the upper zone of electrical transmission towers (tower). In each station, 24 specimens of A36 carbon steel and galvanized steel were placed (12 each). The corrosivity of the environment was measured using the ISO 9223, 9225, and 9226 standards. The specimens were evaluated on-site, monthly, through visual inspection and photographic record. Once withdrawn, the corrosion rate was determined and the corrosion products were analyzed through Raman and Fourier-transform infrared. The results show that, in all cases, the corrosion rate is greater in the tower than on the ground. However, even though the Los Vilos station is located farther from the sea (3,500 vs. ≈500 m), the corrosion rate of steel in the tower is the highest. This is caused by the generation of HCl from the transformation of lepidocrocite into goethite, in the presence of low chloride content, which acidifies the steel/corrosion product interface. In the case of galvanized steel, the corrosion rate is a function of the chloride content in the atmosphere, obtaining an excellent correlation between both parameters. 相似文献
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Effect of the doping time of the 1‐butyl‐3‐methylimidazolium ionic liquid cation on the Nafion membrane proprieties 下载免费PDF全文
Letícia G. da Trindade Letícia Zanchet Katiúscia M.N. Borba Josiane C. Souza Edson R. Leite Emilse M.A. Martini 《国际能源研究杂志》2018,42(11):3535-3543
Nafion membranes were prepared by incorporating in the polymer matrix the 1‐butyl‐3‐methylimidazolium (BMI+) ionic liquid cation at different doping levels. Increasing the doping time of the membranes with the ionic liquid results in increased incorporation of the BMI+ cation but a decrease in the bulk conductivity. The thermogravimetric analysis shows that the BMI+ cation incorporation increases the thermal stability of the membranes. The higher discharge efficiency of the fuel cell at 80°C was obtained by using Nafion membrane after 15 minutes of doping in the ionic liquid solution. 相似文献
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Concentration of Gamma‐Linolenic and Stearidonic Acids as Free Fatty Acids and Ethyl Esters from Viper's Bugloss Seed Oil by Urea Complexation 下载免费PDF全文
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Damaceno Rafael J. P. Rossi Luciano Mugnaini Rogério Mena-Chalco Jesús P. 《Scientometrics》2019,119(1):303-333
Scientometrics - Science can be examined from several standpoints, such as through a bibliometric analysis of the scientific output of researchers, research groups or institutions. However, there... 相似文献
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Software Quality Journal - Risks are an inherent part of any software project. The presence of risks in environments of software development projects requires the perception so that the associated... 相似文献
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Maarten Sijm Julianna Siciliano de Araújo Alba Ramos Llorca Dr. Kristina Orrling Lydia Stiny An Matheeussen Prof. Dr. Louis Maes Prof. Dr. Iwan J. P. de Esch Dr. Maria de Nazaré Correia Soeiro Dr. Geert Jan Sterk Prof. Dr. Rob Leurs 《ChemMedChem》2019,14(18):1662-1668
Chagas disease is becoming a worldwide problem; it is currently estimated that over six million people are infected. The two drugs in current use, benznidazole and nifurtimox, require long treatment regimens, show limited efficacy in the chronic phase of infection, and are known to cause adverse effects. Phenotypic screening of an in-house library led to the identification of 2,2′-methylenebis(5-(4-bromophenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one), a phenyldihydropyrazolone dimer, which shows an in vitro pIC50 value of 5.4 against Trypanosoma cruzi. Initial optimization was done by varying substituents of the phenyl ring, after which attempts were made to replace the phenyl ring. Finally, the linker between the dimer units was varied, ultimately leading to 2,2′-methylenebis(5-(3-bromo-4-methoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one (NPD-0228) as the most potent analogue. NPD-0228 has an in vitro pIC50 value of 6.4 against intracellular amastigotes of T. cruzi and no apparent toxicity against the human MRC-5 cell line and murine cardiac cells. 相似文献
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Dr. Monica Varese Dr. Salvador Guardiola Dr. Jesús García Prof. Ernest Giralt 《Chembiochem : a European journal of chemical biology》2019,20(24):2981-2986
Our laboratory has recently identified two nanobodies (small antibodies produced by camelids)—Nb1 and Nb6—that bind efficiently to epithelial growth factor (EGF) and inhibit its ability to activate its receptor (EGFR). Because of the relevance of the EGF/EGFR axis as a target in oncology, these new nanobodies have promising therapeutic potential. This article, however, is focused on another feature of these nanobodies: their distinct thermodynamic signatures. Nb1 binds to EGF through an entropy-driven mechanism whereas Nb6 binds to this factor under enthalpic control. We discuss the advantages and disadvantages of each mechanism in the contexts of traditional medical chemistry (small-molecule drugs) and also of biological drugs. In this latter case, the implications in terms of selectivity are far from being clearly established and further experimental data are required. Their monomeric natures, high stability, and ease of recombinant production make nanobodies ideally suited for thermodynamic studies. Moreover, nanobodies, thanks to their simpler structures in comparison with conventional antibodies, might provide better understanding of the structural basis of the thermodynamic parameters of antigen recognition. 相似文献