全文获取类型
收费全文 | 4271篇 |
免费 | 459篇 |
国内免费 | 7篇 |
专业分类
电工技术 | 45篇 |
综合类 | 6篇 |
化学工业 | 1074篇 |
金属工艺 | 118篇 |
机械仪表 | 231篇 |
建筑科学 | 76篇 |
矿业工程 | 1篇 |
能源动力 | 186篇 |
轻工业 | 318篇 |
水利工程 | 2篇 |
石油天然气 | 5篇 |
武器工业 | 2篇 |
无线电 | 798篇 |
一般工业技术 | 1069篇 |
冶金工业 | 309篇 |
原子能技术 | 60篇 |
自动化技术 | 437篇 |
出版年
2023年 | 40篇 |
2022年 | 24篇 |
2021年 | 83篇 |
2020年 | 98篇 |
2019年 | 136篇 |
2018年 | 151篇 |
2017年 | 138篇 |
2016年 | 200篇 |
2015年 | 162篇 |
2014年 | 217篇 |
2013年 | 304篇 |
2012年 | 283篇 |
2011年 | 370篇 |
2010年 | 278篇 |
2009年 | 285篇 |
2008年 | 260篇 |
2007年 | 181篇 |
2006年 | 162篇 |
2005年 | 146篇 |
2004年 | 127篇 |
2003年 | 129篇 |
2002年 | 109篇 |
2001年 | 89篇 |
2000年 | 84篇 |
1999年 | 72篇 |
1998年 | 117篇 |
1997年 | 98篇 |
1996年 | 80篇 |
1995年 | 54篇 |
1994年 | 26篇 |
1993年 | 41篇 |
1992年 | 21篇 |
1991年 | 26篇 |
1990年 | 26篇 |
1989年 | 15篇 |
1988年 | 14篇 |
1987年 | 8篇 |
1986年 | 5篇 |
1985年 | 7篇 |
1984年 | 5篇 |
1983年 | 7篇 |
1981年 | 5篇 |
1980年 | 4篇 |
1978年 | 4篇 |
1977年 | 5篇 |
1976年 | 10篇 |
1975年 | 7篇 |
1973年 | 4篇 |
1969年 | 3篇 |
1967年 | 5篇 |
排序方式: 共有4737条查询结果,搜索用时 15 毫秒
1.
Jang Hye Ji Kim Jong Ha Lee Hyun-Sook Paik Hyun-Dong 《Food science and biotechnology》2022,31(6):731-737
Food Science and Biotechnology - The objective of this study was to develop a non-fermented probiotic milk that maintains its physicochemical properties, microbial properties, antioxidant activity,... 相似文献
2.
Jihoon Kim Lauren F. Sestito Sooseok Im Won Jong Kim Susan N. Thomas 《Advanced functional materials》2020,30(16)
Despite the approval of oncolytic virus (OV) therapy for advanced melanoma, its intrinsic limitations that include the risk of persistent viral infection and cost‐intensive manufacturing motivate the development of analogous approaches that are free from the disadvantages of virus‐based therapies. Herein, reported is a nanoassembly comprised of multivalent host–guest interactions between polymerized paclitaxel (pPTX) and nitric oxide‐incorporated polymerized β‐cyclodextrin (pCD‐pSNO) that through its bioactive components and when used locoregionally recapitulates the therapeutic effects of OV. The resultant pPTX/pCD‐pSNO exhibits significantly enhanced cytotoxicity, immunogenic cell death, dendritic cell (DC) activation, and T cell expansion in vitro compared to free agents alone or in combination. In vivo, intratumoral administration of pPTX/pCD‐pSNO results in activation and expansion of DCs systemically, but with a corresponding expansion of myeloid‐derived suppressor cells and suppression of CD8+ T cell expansion. When combined with antibody targeting cytotoxic T lymphocyte antigen‐4 that blunts this molecule's signaling effects on T cells, intratumoral pPTX/pCD‐pSNO treatment elicits potent anticancer effects that significantly prolong animal survival. This formulation thus leverages the chemo‐ and immunotherapeutic synergies of PTX and nitric oxide and suggests the potential for virus‐free nanoformulations to mimic the therapeutic action and benefits of OVs. 相似文献
3.
Multimedia Systems - The preferences of Web information purchasers are changing. Cost-effectiveness (i.e., an emphasis on performance with respect to price) is becoming less regarded than... 相似文献
4.
Sangki Park Seongcheol Ahn Jingzhe Sun Divij Bhatia Dukhyun Choi Kap Seung Yang Jihyun Bae Jong‐Jin Park 《Advanced functional materials》2019,29(10)
Human joints have respective ranges of motion and joint forces corresponding to each kind of joint; this necessitates considerations of the characteristics of human joints to fabricate wearable strain sensors conformable to the human body, and capable of precisely monitoring complex motions of the human body. In the present study, the “all textile‐based highly stretchable structure” that is capable of precisely sensing motions (folding and rotation) of the human joints (finger, wrist, elbow, spine, and knee) is fabricated by optimizing patterns (straight, blind, and zigzag) of conductive yarns employed as the conductive part of the strain sensor, and several textile substrates (braided elastic fabric, knit fabric, and woven fabric), having preferable elasticity and conformability employed for the fabrication of strain sensors suitable for human joints. In particular, the technology, enabling the prestraining of textile substrate, is exploited to fabricate a strain sensor that is capable of outputting selective signals corresponding to the folding motion of the spinal joint over a predetermined angle of motion, and the gait pattern of the wearer of the sensor, attached to his or her knee joint doing folding and rotational motions, is analyzed. 相似文献
5.
Dr. Ala Jo Mingi Kim Dr. Jong In Kim Jaeyoung Ha Yoon Soo Hwang Hyunsung Nam Dr. Injae Hwang Dr. Jae Bum Kim Prof. Seung Bum Park 《ChemMedChem》2021,16(7):1104-1115
Obesity has become a pandemic that threatens the quality of life and discovering novel therapeutic agents that can reverse obesity and obesity-related metabolic disorders are necessary. Here, we aimed to identify new anti-obesity agents using a phenotype-based approach. We performed image-based high-content screening with a fluorogenic bioprobe (SF44), which visualizes cellular lipid droplets (LDs), to identify initial hit compounds. A structure-activity relationship study led us to yield a bioactive compound SB1501, which reduces cellular LDs in 3T3-L1 adipocytes without cytotoxicity. SB1501 induced the expression of gene products that regulate mitochondrial biogenesis and fatty acid oxidation in 3T3-L1 adipocytes. Daily treatment with SB1501 improved the metabolic states of db/db mice by reducing body fat mass, adipose tissue mass, food intake, and increasing glucose tolerance. The anti-obesity effect of SB1501 may result from perturbation of the PGC-1α–UCP1 regulatory axis in inguinal white adipose tissue and brown adipose tissue. These data suggest the therapeutic potential of SB1501 as an anti-obesity agent via modulating mitochondrial activities. 相似文献
6.
Ohjin Kwon Xiaoqian Cai Wentao Qu Feng Liu Jadwiga Szydłowska Ewa Gorecka Moon Jong Han Dong Ki Yoon Silvio Poppe Carsten Tschierske 《Advanced functional materials》2021,31(28):2102271
First examples of multichain (polycatenar) compounds, based on the π-conjugated [1]benzothieno[3,2-b]benzothiophene unit are designed, synthesized, and their soft self-assembly and charge carrier mobility are investigated. These compounds, terminated by the new fan-shaped 2-brominated 3,4,5-trialkoxybenzoate moiety, form bicontinuous cubic liquid crystalline (LC) phases with helical network structure over extremely wide temperature ranges (>200 K), including ambient temperature. Compounds with short chains show an achiral cubic phase with the double network, which upon increasing the chain length, is at first replaced by a tetragonal 3D phase and then by a mirror symmetry is broken triple network cubic phase. In the networks, the capability of bypassing defects provides enhanced charge carrier mobility compared to imperfectly aligned columnar phases, and the charge transportation is non-dispersive, as only rarely observed for LC materials. At the transition to a semicrystalline helical network phase, the conductivity is further enhanced by almost one order of magnitude. In addition, a mirror symmetry broken isotropic liquid phase is formed beside the 3D phases, which upon chain elongation is removed and replaced by a hexagonal columnar LC phase. 相似文献
7.
8.
Sang-Chae Jeon Jae-Won Lee Joo-Young Yoon Yung-Zun Cho Dong-Joo Kim Dong Seok Kim Keon Sik Kim Jong Hun Kim Jae Ho Yang 《Ceramics International》2019,45(6):6863-6868
A reduction process in the head-end for pyroprocessing has been adopted to avoid oxidation attack on the molybdenum crucible during sintering. The reduction process is employed to reduce U3O8 pellets to UO2 prior to sintering. This allows elimination of the oxygen source, which causes oxidation attack during sintering, thereby permitting the use of a metallic crucible. However, little densification occurs due to the low reduction temperature limited by the INCONEL crucible. Consequently, the amount of material scraps from the pellets increases, thus creating an additional processing burden due to its high radioactivity. To reduce the amount of scraps, densification should be enhanced. This study suggests a simple atmospheric control strategy and clarifies its effects. With the atmospheric control, a higher bulk density and better attrition resistance were obtained in comparison to without this strategy. This can be explained in terms of O/U ratio dependent diffusion kinetics during the reduction of U3O8 to UO2. 相似文献
9.
10.
Keshab Kumar Karna Na Young Choi Chul Young Kim Hye Kyung Kim Yu Seob Shin Jong Kwan Park 《International journal of molecular sciences》2020,21(23)
Gui-A-Gra, a commercial insect powder from Gryllus bimaculatus, is registered as an edible insect by the Korean food and drug administration. The aim of this study was to investigate the effect of Gui-A-Gra on testicular damage induced by experimental left varicocele in male Sprague Dawley rats. A total of 72 rats were randomly divided into the following six groups (12 rats in each group): a normal control group (CTR), a group administrated with Gui-A-Gra 1.63 gm/kg (G1.63), a group administrated with Gui-A-Gra 6.5 gm/kg (G6.5), a varicocele (VC)-induced control group (VC), a VC-induced group administrated with Gui-A-Gra 1.63 gm/kg (VC + G1.63), and a VC-induced group administrated with Gui-A-Gra 6.5 gm/kg (VC + G6.5). Rats were administrated 1.63 or 6.5 gm/kg Gui-A-Gra once daily for 42 days. Indicators of sperm parameters, histopathology, reproductive hormones, oxidative stress, endoplasmic reticulum (ER) stress, inflammation, and mitochondrial apoptosis were analyzed to evaluate effects of Gui-A-Gra on VC-induced testicular dysfunction. Gui-A-Gra administration to VC-induced rats significantly (p < 0.05) increased sperm count and sperm motility, Johnsen score, spermatogenic cell density, serum testosterone, testicular superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase, GPx4, and steroidogenic acute regulatory protein (StAR) level. Moreover, pretreatment with Gui-A-Gra significantly (p < 0.05) decreased terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) positive cells/tubules, serum luteinizing hormone (LH), serum follicle-stimulating hormone (FSH), testicular tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), malondialdehyde (MDA), reactive oxygen species (ROS)/reactive nitrogen species (RNS) level, glucose-regulated protein-78 (Grp-78), phosphorylated c-Jun-N-terminal kinase (p-JNK), phosphorylated inositol-requiring transmembrane kinase/endoribonuclease 1α (p-IRE1α), cleaved caspase-3, and BCL2 associated X protein: B-cell lymphoma 2 (Bax: Bcl2) ratio in VC rats. These results suggest that protective effects of Gui-A-Gra on VC-induced testicular injury might be due to its antioxidant, anti-inflammatory, and androgenic activities that might be mediated via crosstalk of oxidative stress, ER stress, and mitochondrial apoptosis pathway. 相似文献