Experimental determination of 3D crack propagation scenario in resistance spot welds of a martensitic stainless steel

International Journal of Fracture - The development of high-performance automotive steels involves increasingly complex chemistries and heat treating sequences, to produce stronger and lighter...     

Software HEVC video decoder: towards an energy saving for mobile applications

Multimedia Tools and Applications - With the explosive growth of mobile video consumption over the Internet, delivering video at high quality while controlling the energy consumption of embedded...     

A Machine Vision Sensor for Quality Control of Green Anode Paste Material

JOM - A machine vision sensor was developed for predicting deviations from the optimum amount of pitch in anode formulations using paste texture analysis. It could help operators mitigate the...     

Cyanogenic,carotenoids and protein composition in leaves and roots across seven diverse population found in the world cassava germplasm collection at CIAT,Colombia

The objective of this study was to characterise the nutritional potential of leaves and identify a diversity centre with low cyanide and high nutrient content among 178 Latin American cassava genotypes. This field-based collection represents the seven diversity centres, held at The International Center for Tropical Agriculture (CIAT Palmira, Colombia) by the Cassava Program. The cyanide, all-trans-β-carotene and lutein concentrations in cassava leaves ranged from 346 to 7484 ppm dry basis (db), from 174–547 μg g⁻¹ db and 15–181 μg g⁻¹ db, respectively. Cassava leaves also showed significant levels of essential amino acids leucine, lysine, phenylalanine, valine and threonine, and average total protein content of 26.24 g 100 g⁻¹ db. Among seven diversity centres, South American rainforest group showed low cyanide and high carotene content in leaves. In addition, VEN77 and PAN51 genotypes stood out for having low cyanide in leaves and roots and high carotene in leaves. This genetic diversity can be used to select high potential progenitors for breeding purposes.     

Lamin-Related Congenital Muscular Dystrophy Alters Mechanical Signaling and Skeletal Muscle Growth

Laminopathies are a clinically heterogeneous group of disorders caused by mutations in the LMNA gene, which encodes the nuclear envelope proteins lamins A and C. The most frequent diseases associated with LMNA mutations are characterized by skeletal and cardiac involvement, and include autosomal dominant Emery–Dreifuss muscular dystrophy (EDMD), limb-girdle muscular dystrophy type 1B, and LMNA-related congenital muscular dystrophy (LMNA-CMD). Although the exact pathophysiological mechanisms responsible for LMNA-CMD are not yet understood, severe contracture and muscle atrophy suggest that mutations may impair skeletal muscle growth. Using human muscle stem cells (MuSCs) carrying LMNA-CMD mutations, we observe impaired myogenic fusion with disorganized cadherin/β catenin adhesion complexes. We show that skeletal muscle from Lmna-CMD mice is unable to hypertrophy in response to functional overload, due to defective fusion of activated MuSCs, defective protein synthesis and defective remodeling of the neuromuscular junction. Moreover, stretched myotubes and overloaded muscle fibers with LMNA-CMD mutations display aberrant mechanical regulation of the yes-associated protein (YAP). We also observe defects in MuSC activation and YAP signaling in muscle biopsies from LMNA-CMD patients. These phenotypes are not recapitulated in closely related but less severe EDMD models. In conclusion, combining studies in vitro, in vivo, and patient samples, we find that LMNA-CMD mutations interfere with mechanosignaling pathways in skeletal muscle, implicating A-type lamins in the regulation of skeletal muscle growth.     

BMS Derivatives C7-Linked to β-Cyclodextrin and Hyperbranched Polyglycerol Retain Activity against R5-HIV-1NLAD8 Isolates and Can Be Deemed Potential Microbicides

Amides from indole-3-glyoxylic acid and 4-benzoyl-2-methylpiperazine, which are related to entry inhibitors developed by Bristol-Myers Squibb (BMS), have been synthesized with aliphatic chains located at the C7 position of the indole ring. These spacers contain an azido group suitable for the well-known Cu(I)-catalyzed (3+2)-cycloaddition or an activated triple bond for the nucleophilic addition of thiols under physiological conditions. Reaction with polyols (β-cyclodextrin and hyperbranched polyglycerol) decorated with complementary click partners has afforded polyol-BMS-like conjugates that are not cytotoxic (TZM.bl cells) and retain the activity against R5-HIV-1_NLAD8 isolates. Thus, potential vaginal microbicides based on entry inhibitors, which can be called of 4^th generation, are reported here for the first time.     

Divergent Synthesis of Novel Cylindrocyclophanes that Inhibit Methicillin-Resistant Staphylococcus aureus (MRSA)

The cylindrocyclophanes are a family of macrocyclic natural products reported to exhibit antibacterial activity. Little is known about the structural basis of this activity due to the challenges associated with their synthesis or isolation. We hypothesised that structural modification of the cylindrocyclophane scaffold could streamline their synthesis without significant loss of activity. Herein, we report a divergent synthesis of the cylindrocyclophane core enabling access to symmetrical macrocycles by means of a catalytic, domino cross-metathesis-ring-closing metathesis cascade, followed by late-stage diversification. Phenotypic screening identified several novel inhibitors of methicillin-resistant Staphylococcus aureus. The most potent inhibitor has a unique tetrabrominated [7,7]paracyclophane core with no known counterpart in nature. Together these illustrate the potential of divergent synthesis using catalysis and unbiased screening methods in modern antibacterial discovery.     

Nucleation and crystallization of Ba2Si3O8 spherulites in a barium aluminum silicate glass,and mechanical properties of the obtained glass-ceramics

The effect of spherulitic crystallization on the elastic moduli and fracture toughness of a barium aluminum silicate glass was investigated. The crystallization process results in Ba₂Si₃O₈ phase and is initiated from Ba rich nuclei. Nucleation is optimal in the 690-720 °C interval. Young’s modulus is increased by 12.5% when the glass-ceramic conversion is nearly complete. Nevertheless, as the size and the volume fraction of crystals are increased, some microcracking shows up upon cooling from the crystallization temperature. An optimal improvement of the fracture toughness (SEPB method) by 27 % is observed for a 49 % volume fraction of 5 to 10 μm large spherulites.     

A quantitative risk assessment of a domestic property connected to a hydrogen distribution network

The increased reliance on natural gas for heating worldwide makes the search for carbon-free alternatives imperative, especially if international decarbonisation targets are to be met. Hydrogen does not release carbon dioxide (CO₂) at the point of use which makes it an appealing candidate to decarbonise domestic heating. Hydrogen can be produced from either 1) the electrolysis of water with no associated carbon emissions, or 2) from methane reformation (using steam) which produces CO₂, but which is easily captured and storable during production. Hydrogen could be transported to the end-user via gas distribution networks similar to, and adapted from, those in use today. This would reduce both installation costs and end-user disruption. However, before hydrogen can provide domestic heat, it is necessary to assess the ‘risk’ associated with its distribution in direct comparison to natural gas. Here we develop a comprehensive and multi-faceted quantitative risk assessment tool to assess the difference in ‘risk’ between current natural gas distribution networks, and the potential conversion to a hydrogen based system. The approach uses novel experimental and modelling work, scientific literature, and findings from historic large scale testing programmes. As a case study, the risk assessment tool is applied to the newly proposed H100 demonstration (100% hydrogen network) project. The assessment includes the comparative risk of gas releases both upstream and downstream of the domestic gas meter. This research finds that the risk associated with the proposed H100 network (based on its current design) is lower than that of the existing natural gas network by a factor 0.88.