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排序方式: 共有434条查询结果,搜索用时 15 毫秒
1.
Wireless Personal Communications - Today’s world has a keen interest in systems which are battery-less and can harvest energy from their surroundings. There is an increased demand for... 相似文献
2.
Nikhil K. Tulsian Valerie Jia-En Sin Hwee-Ling Koh Ganesh S. Anand 《International journal of molecular sciences》2021,22(10)
Phosphodiesterases (PDEs) hydrolyze cyclic nucleotides to modulate multiple signaling events in cells. PDEs are recognized to actively associate with cyclic nucleotide receptors (protein kinases, PKs) in larger macromolecular assemblies referred to as signalosomes. Complexation of PDEs with PKs generates an expanded active site that enhances PDE activity. This facilitates signalosome-associated PDEs to preferentially catalyze active hydrolysis of cyclic nucleotides bound to PKs and aid in signal termination. PDEs are important drug targets, and current strategies for inhibitor discovery are based entirely on targeting conserved PDE catalytic domains. This often results in inhibitors with cross-reactivity amongst closely related PDEs and attendant unwanted side effects. Here, our approach targeted PDE–PK complexes as they would occur in signalosomes, thereby offering greater specificity. Our developed fluorescence polarization assay was adapted to identify inhibitors that block cyclic nucleotide pockets in PDE–PK complexes in one mode and disrupt protein-protein interactions between PDEs and PKs in a second mode. We tested this approach with three different systems—cAMP-specific PDE8–PKAR, cGMP-specific PDE5–PKG, and dual-specificity RegA–RD complexes—and ranked inhibitors according to their inhibition potency. Targeting PDE–PK complexes offers biochemical tools for describing the exquisite specificity of cyclic nucleotide signaling networks in cells. 相似文献
3.
Kumar Nikhil Verma A. K. Sardana Sahil Sarkar K. Singh T. N. 《Bulletin of Engineering Geology and the Environment》2018,77(2):595-608
Bulletin of Engineering Geology and the Environment - Landslides that occur due to the rapid motion of a rock-mass are a primary risk in mountainous terrains and are a danger to human life and... 相似文献
4.
Lokesh Kulhari Kanad Ray Ankit Paptan Nikhil Suri Pramod K Khanna 《International Journal of Applied Ceramic Technology》2020,17(3):1430-1439
Low temperature co-fired ceramic (LTCC) micro-hotplates show wide applications in gas sensors and micro-fluidic devices. It is easily structured in three-dimensional structures. This paper presents the low power consumption micro-hotplates which were developed with PTC (positive temperature coefficient) temperature sensor and inter-digitated electrodes. The paper presents two different structures for micro-hotplate with platinum as a heating element. The PTC temperature sensor using two different materials viz. PdAg and platinum paste are developed with micro-hotplates. The simulation has been achieved through COMSOL for LTCC and alumina micro-hotplates. The temperature variation with power consumption has been measured for the developed LTCC micro-hotplates. The change in resistance of PTC temperature sensors was measured with micro-hotplate temperature. The aim of this study was to place a temperature sensor with the gas sensor module to measure and control the temperature of micro-hotplate. A SnO2 sensing layer is coated on LTCC micro-hotplate using screen printing and characterized for the sensing of carbon monoxide gas (CO). This study will be beneficial for designing hotplates based on LTCC technology with low power consumption and better stability of temperature for gas-sensing applications. 相似文献
5.
This paper proposes a novel hybrid technique called enhanced grey wolf optimization-sine cosine algorithm-cuckoo search (EGWO-SCA-CS) algorithm to improve the electrical power system stability. The proposed method comprises of a popular grey wolf optimization (GWO) in an enhanced and hybrid form. It embraces the well-balanced exploration and exploitation using the cuckoo search (CS) algorithm and enhanced search capability through the sine cosine algorithm (SCA) to elude the stuck to the local optima. The proposed technique is validated with the 23 benchmark functions and compared with state-of-the-art methods. The benchmark functions consist of unimodal, multimodal function from which the best suitability of the proposed technique can be identified. The robustness analysis also presented with the proposed method through boxplot, and a detailed statistical analysis is performed for a set of 30 individual runs. From the inferences gathered from the benchmark functions, the proposed technique is applied to the stability problem of a power system, which is heavily stressed with the nonlinear variation of the load and thereby operating conditions. The dynamics of power system components have been considered for the mathematical model of a multimachine system, and multiobjective function has been framed in tuning the optimal controller parameters. The effectiveness of the proposed algorithm has been assessed by considering two case studies, namely, (i) the optimal controller parameter tuning, and (ii) the coordination of oscillation damping devices in the power system stability enhancement. In the first case study, the power system stabilizer (PSS) is considered as a controller, and a self-clearing three-phase fault is considered as the system uncertainty. In contrast, static synchronous compensator (STATCOM) and PSS are considered as controllers to be coordinated, and perturbation in the system states as uncertainty in the second case study. 相似文献
6.
Bonding between polymers through interdiffusion of macromolecules is a well-known mechanism of polymer adhesion. A new polymer bonding mechanism in the solid state, taking place at ambient temperatures well below the glass transition value (Tg), has been recently reported; in this mechanism, bulk plastic compression of polymer films held in contact led to adhesion over timescales of the order of a fraction of a second. In this study, we prepared various blends of plasticized polymer films with desirable ductility from amorphous and semicrystalline powders of hydroxypropyl methylcellulose and polyvinyl alcohol derivatives; then, we observed the bonding of these polymers at ambient temperatures, up to 80 K below Tg, purely through mechanical deformation. The deformation-induced bonding of the polymer films studied in this work led to interfacial fracture toughnesses in the range of 1.0–21.0 J/m2 when bulk plastic strains between 3% and 30% were imposed across the films. Scanning electron microscopy observation of the debonded interfaces also confirmed that bonding was caused by deformation-induced macromolecular mobilization and interpenetration. These results expand the range of applicability of sub-Tg, solid-state, deformation-induced bonding processes. 相似文献
7.
8.
In this paper, a fault direction estimation algorithm is proposed for a double-circuit line with thyristor controlled series capacitor (TCSC) using principal component analysis (PCA)-based technique. In case of PCA, an orthogonal transformation is used to convert correlated variables into linearly uncorrelated variables called principal components. Fault in such a compensated line leads to voltage inversion, current inversion, and subsynchronous resonance situations, which affect the performance of the conventional direction estimation process. Transients associated with metal oxide varistor (MOV) operation and control action associated with TCSC, further modulate equivalent impedance of TCSC and MOV combination. In the proposed approach, PCA of angles between positive and negative sequence components of voltage current has been carried out to extract the pattern and to declare the fault direction accurately. The double-circuit line with TCSC is simulated using PSCAD/EMTDC software. The performance of the proposed technique is tested for numerous test cases, and it was found to be accurate. 相似文献
9.
The present study aims at studying ageing characteristics of conventional bitumen, polymer modified bitumen (PMB) and warm mix asphalt (WMA) by using FTIR. Results of obtained FTIR spectrum were quantified by calculating different indices and finally based on these indices ageing index of the binders for short- and long-term ageing were calculated. Results showed ageing increased amount of complex and high molecular weight components of the binders. PMB was found to have greater ageing resistance than conventional asphalt binders. In case of WMA, results found to be inconclusive, requiring further investigation. 相似文献
10.