Conservative Approximation–Based Full‐Search Block Matching Algorithm Architecture for QCIF Digital Video Employing Systolic Array Architecture

This paper presents a power‐efficient hardware realization for a motion estimation technique that is based on the full‐search block matching algorithm (FSBMA). The considered input is the quarter common intermediate format of digital video. The mean of absolute difference (MAD) is the distortion criteria employed for the block matching process. The conventional architecture considered for the hardware realization of FSBMA is that of the shift register–based 2‐D systolic array. For this architecture, a conservative approximation technique is adapted to eliminate unnecessary MAD computations involved in the block matching process. Upon introducing the technique to the conventional architecture, the power and complexity of its implantation is reduced, while the accuracy of the motion vector extracted from the block matching process is preserved. The proposed architecture is verified for its functional specifications. A performance evaluation of the proposed architecture is carried out using parameters such as power, area, operating frequency, and efficiency.     

Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation

The effect of consuming red wine, or its major polyphenol constituents catechin or quercetin, on the development of atherosclerotic lesions, in relation to the susceptibility of plasma LDL to oxidation and to aggregation, was studied in atherosclerotic apolipoprotein E deficient (E degree) mice. Forty E degree mice at the age of 4 weeks were divided into four groups, 10 mice in each group, and were supplemented for up to 6 weeks in their drinking water with placebo (1.1% alcohol); catechin or quercetin (50 micrograms/d per mouse), or red wine (0.5 mL/d per mouse). Consumption of catechin, quercetin, or red wine had no effect on plasma LDL or HDL cholesterol levels. The atherosclerotic lesion area was smaller in the treated mice by 39%, 46%, and 48%, respectively, in comparison with E degree mice that were treated with placebo. In accordance with these findings, cellular uptake of LDL derived after catechin, quercetin, or red wine consumption was found to be reduced by 31%, 40%, and 52%, respectively. These results were associated with reduced susceptibility to oxidation (induced by different modes such as copper ions, free radical generator, or macrophages) of LDL isolated after red wine or quercetin and, to a lesser extent after catechin consumption, in comparison with LDL isolated from the placebo group. Similar results were obtained when LDL was preincubated in vitro with red wine or with the polyphenols prior to its oxidation. Even in the basal oxidative state (not induced oxidation), LDL isolated from E degree mice that consumed catechin, quercetin, or red wine for 2 weeks was found to be less oxidized in comparison with LDL isolated from E degree mice that received placebo, as evidenced by 39%, 48%, and 49% reduced content of LDL-associated lipid peroxides, respectively. This effect could be related to enhanced serum paraoxonase activity in the polyphenol-treated mice. LDL oxidation was previously shown to lead to its aggregation. The present study demonstrated that the susceptibility of LDL to aggregation was reduced in comparison with placebo-treated mice, by 63%, 48%, or 50% by catechin, quercetin, and red wine consumption, respectively, and this effect could be shown also in vitro. The inhibition of LDL oxidation by polyphenols could be related, at least in part, to a direct effect of the polyphenols on the LDL, since both quercetin and catechin were found to bind to the LDL particle via the formation of an ether bond. We thus conclude that dietary consumption by E degree mice of red wine or its polyphenolic flavonoids quercetin and, to a lesser extent, catechin leads to attenuation in the development of the atherosclerotic lesion, and this effect is associated with reduced susceptibility of their LDL to oxidation and aggregation.     

Bulk and interfacial physical properties of aqueous solutions of sodium lauryl sulphate and lauryl alcohol with air and benzene system: Part I: Aqueous solutions of sodium lauryl sulphate

Experimental measurements were made of the pH, density, bulk viscosity and electrical conductivity of aqueous solutions of sodium lauryl sulphate for a wide range of concentrations at 25°C. Also, the time-dependent interfacial tension data of this system with mutually saturated benzene phases are reported. Comparison of these data with literature values shows fair agreement in the majority of the cases and further reveals the lack of data in the earlier investigations below the critical micelle concentration of sodium lauryl sulphate in water. A detailed compilation of the data, reported in the literature since 1937, of the pH, density, bulk viscosity, electrical conductivity, surface tension, interfacial tension with benzene, surface excess concentration, surface shear viscosity, diffusivity and critical micelle concentration of the sodium lauryl sulphate system is given. The importance of this anionic surfactant system together with the various factors which influence the physical properties is examined.     

A new bistable laser diode configuration for all optical switching

A new bistable laser diode configuration for all optical switching has been suggested and its equivalent circuit model is developed. For switching the device to the high state (set) a TE mode optical pulse is required, which is the oscillating mode of the laser, whereas a TM mode pulse is used to bring the output to a low state (reset). But the wavelength of the set and reset pulses are the same as that of the lasing wavelength of the device. The static and dynamic characteristics are studied by simulating the equivalent circuit model using the circuit simulation program PSPICE. It is found that as the carrier lifetime τ_a of the absorption section increases, the width of the optical pulse required for reset increases nonlinearly. The rise and fall times are found to be 0.15 and 0.16 ns, respectively, for a τ _a, of 3 ns     

A parallel 3-D discrete wavelet transform architecture using pipelined lifting scheme approach for video coding

This article presents a parallel architecture for 3-D discrete wavelet transform (3-DDWT). The proposed design is based on the 1-D pipelined lifting scheme. The architecture is fully scalable beyond the present coherent Daubechies filter bank (9,?7). This 3-DDWT architecture has advantages such as no group of pictures restriction and reduced memory referencing. It offers low power consumption, low latency and high throughput. The computing technique is based on the concept that lifting scheme minimises the storage requirement. The application specific integrated circuit implementation of the proposed architecture is done by synthesising it using 65?nm Taiwan Semiconductor Manufacturing Company standard cell library. It offers a speed of 486?MHz with a power consumption of 2.56?mW. This architecture is suitable for real-time video compression even with large frame dimensions.     

Diffuse optical spectroscopic imaging correlates with final pathological response in breast cancer neoadjuvant chemotherapy

Diffuse optical spectroscopic imaging (DOSI) non-invasively and quantitatively measures tissue haemoglobin, water and lipid. Pilot studies in small groups of patients demonstrate that DOSI may be useful for longitudinal monitoring and predicting breast cancer neoadjuvant chemotherapy pathological response. This study evaluates the performance of a bedside DOSI platform in 34 breast cancer patients followed for several months. DOSI optical endpoints obtained at multiple timepoints are compared with final pathological response. Thirty-six stage II/III breast cancers (34 patients) were measured in vivo with DOSI prior to, in the middle of and after the completion of pre-surgical neoadjuvant chemotherapy. Cancer therapies ranged from standard anthracyclines to targeted therapies. Changes in DOSI-measured parameters at each timepoint were compared against final surgical pathology. Absolute changes in the tumour-to-normal (T/N) ratio of tissue deoxyhaemoglobin concentration (ctHHb) and relative changes in the T/N ratio of a tissue optical index (TOI) were most sensitive and correlate to pathological response. Changes in ctHHb and TOI were significantly different between tumours that achieved pathological complete response (pCR) versus non-pCR. By therapy midpoint, mean TOI-T/N changes were 47±8 versus 20±5 per cent for pCR versus non-pCR subjects, respectively (Z=0.011). Changes in ctHHb and TOI scaled significantly with the degree of pathological response (non-, partial and complete). DOSI measurements of TOI separated pCR from non-pCR by therapy midpoint regardless of drug or dosing strategy. This approach is well suited to monitoring breast tumour response and may provide feedback for optimizing therapeutic outcomes and minimizing side-effects.     

A.C. field effect study on PbTe films grown by hot wall epitaxy technique

The field effect mobility on the free surface of PbTe films grown by hot wall epitaxy (HWE) technique ona KCl substrate was studied as a function of frequency in the range 40–200 kHz at different temperatures from 98–156 K. Using Garrett's theory of the frequency dependence of field-effect mobility, the relaxation times of surface states were found to vary from 1.84 to 0.96 μsec in the above temperature range. From Rupprecht's relation on temperature dependence of relaxation times, the energy level of surface states was found to be 0.02 eV below the conduction band with an effective capture cross section of the order 10^?19 cm².     

An investigational back surface cooling approach with different designs of heat‐absorbing pipe for PV/T system

A solar photovoltaic panel accumulates substantial amount of heat, which deteriorates its performance. Thus, to minimize the panel temperature, 3 new designs (semioval serpentine, circular spiral, and circular spiral semiflattened) of absorbers for back surface cooling are introduced in this paper. Experimental investigations on the panel performances with and without the designed cooling systems are performed. A similar experiment with an existing serpentine design of absorbers is also conducted, and the results of all the experiments are compared. The circular spiral semiflattened design absorber has shown preeminent performance among all the absorbers in terms of the highest improvement in efficiency (4.32%), fill factor (19.80%), etc.     

An efficient 3-dimensional discrete wavelet transform architecture for video processing application

This paper presents an optimized 3-D Discrete Wavelet Transform (3-DDWT) architecture. 1-DDWT employed for the design of 3-DDWT architecture uses reduced lifting scheme approach. Further the architecture is optimized by applying block enabling technique, scaling, and rounding of the filter coefficients. The proposed architecture uses biorthogonal (9/7) wavelet filter. The architecture is modeled using Verilog HDL, simulated using ModelSim, synthesized using Xilinx ISE and finally implemented on Virtex-5 FPGA. The proposed 3-DDWT architecture has slice register utilization of 5%, operating frequency of 396 MHz and a power consumption of 0.45 W.     

Structural aspects of the inhibitory effect of glabridin on LDL oxidation

The inhibitory effects of glabridin, an isoflavan isolated from licorice (Glycyrrhiza glabra) root, and its derivatives on the oxidation of LDL induced by copper ions or mediated by macrophages were studied, in order to evaluate the contribution of the different parts of the isoflavan molecule to its antioxidant activity. The peak potential (E1/2) of the isoflavan derivatives, their radical scavenging capacity toward 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical and their ability to chelate heavy metals were also analyzed and compared to their inhibitory activity on LDL oxidation. In copper ion-induced LDL oxidation, glabridin (1), 4'-O-methylglabridin (2), hispaglabridin A (3), and hispaglabridin B (4), which have two hydroxyl groups at positions 2' and 4' or one hydroxyl at position 2' on ring B, successfully inhibited the formation of conjugated dienes, thiobarbituric acid reactive substances (TBARS) and lipid peroxides, and inhibited the electrophoretic mobility of LDL under oxidation. Compounds 1-3 exhibited similar activities, whereas compound 4 was less active. In macrophage-mediated LDL oxidation, the TBARS formation was also inhibited by these isoflavans (1-4) at a similar order of activity to that obtained in copper ion-induced LDL oxidation. On the other hand, 2'-O-methylglabridin (5), a synthesized compound, whose hydroxyl at 2'-position is protected and the hydroxyl at 4'-position is free, showed only minor inhibitory activity in both LDL oxidation systems. 2',4'-O-Dimethylglabridin (6), whose hydroxyls at 2'- and 4'-positions are both protected, was inactive. Resorcinol (7), which is identical to the phenolic B ring in glabridin, presented low activity in these oxidation systems. The isoflavene glabrene (8), which contains an additional double bond in the heterocyclic C ring, was the most active compound of the flavonoid derivatives tested in both oxidation systems. The peak potential of compounds 1-5 (300 microM), tested at pH 7.4, was similar (425-530 mV), and that for compound 6 and 8 was 1078 and 80 mV, respectively. Within 30 min of incubation, compounds 1, 2, 3, 4, 8 scavenged 31%, 16%, 74%, 51%, 86%, respectively, of DPPH radical, whereas compounds 5 and 6, which almost did not inhibit LDL oxidation, also failed to scavenge DPPH. None of the isoflavan derivatives nor the isoflavene compound were able to chelate iron, or copper ions. These results suggest that the antioxidant effect of glabridin on LDL oxidation appears to reside mainly in the 2' hydroxyl, and that the hydrophobic moiety of the isoflavan is essential to obtain this effect. It was also shown that the position of the hydroxyl group at B ring significantly affected the inhibitory efficiency of the isoflavan derivatives on LDL oxidation, but did not influence their ability to donate an electron to DPPH or their peak potential values.