Sex and Race-Related DNA Methylation Changes in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is the sixth most common cancer and fourth leading cause of cancer-related death worldwide. The number of HCC cases continues to rise despite advances in screening and therapeutic inventions. More importantly, HCC poses two major health disparity issues. First, HCC occurs more commonly in men than women. Second, with the global increase in non-alcoholic fatty liver diseases (NAFLD), it has also become evident that HCC is more prevalent in some races and/or ethnic groups compared to others, depending on its predisposing etiology. Most studies on HCC in the past have been focused on genetic factors as the driving force for HCC development, and the results revealed that genetic mutations associated with HCC are often heterogeneous and involve multiple pathogenic pathways. An emerging new research field is epigenetics, in which gene expression is modified without altering DNA sequences. In this article, we focus on reviewing current knowledge on HCC-related DNA methylation changes that show disparities among different sexes or different racial/ethnic groups, in an effort to establish a point of departure for resolving the broader issue of health disparities in gastrointestinal malignancies using cutting-edge epigenetic approaches.     

Connection admission control for capacity-varying networks withstochastic capacity change times

Many connection-oriented networks, such as low Earth orbit satellite (LEOS) systems and networks providing multipriority service using advance reservations, have capacities which vary over time. Connection admission control (CAC) policies which only use current capacity information may lead to intolerable dropping of admitted connections whenever network capacity decreases. We present the admission limit curve (ALC) for capacity-varying networks with random capacity change times. We prove the ALC is a constraint limiting the conditions under which any connection-stateless CAC policy may admit connections and still meet dropping guarantees on an individual connection basis. The ALC also leads to a lower bound on the blocking performance achievable by any connection-stateless CAC policy which provides dropping guarantees to individual connections. In addition, we describe a CAC policy for stochastic capacity change times which uses knowledge about future capacity changes to provide dropping guarantees on an individual connection basis and which achieves blocking performance close to the lower bound     

Initial implementations of point-to-point Ethernet over SONET/SDH transport

There is considerable interest in using Ethernet over SONET/SDH (EoS) for Ethernet transport in a wide area network. EoS leverages the existing SONET/SDH infrastructure to provide efficient Ethernet transport with excellent OAM capabilities. In our initial evaluations and deployments of EoS, we have encountered some issues, as is common with any new technology. These issues include non-transparent transport of Ethernet information, lack of carrier-class performance monitoring and fault propagation, and non-standardized implementation of basic concepts. Vendors, service providers, and standards bodies should work together to resolve these remaining issues and thus bring forth the full potential of EoS.     

Call admission control for capacity-varying networks

Many networks, such as Non-Geostationary Orbit Satellite (NGOS) networks and networks providing multi-priority service using advance reservations, have capacities which vary over time for some or all types of calls carried on these networks. For connection-oriented networks, Call Admission Control (CAC) policies which only use current capacity information may lead to excessive and intolerable dropping of admitted calls whenever the network capacity decreases. Thus, novel CAC policies are required for these networks. Three such CAC policies are discussed, two for calls with exponentially distributed call holding times and one for calls whose holding time distributions have Increasing Failure Rate (IFR) functions. The Admission Limit Curve (ALC) is discussed and shown to be a constraint limiting the conditions under which any causal CAC policy may admit calls and still meet call dropping guarantees on an individual call basis. We demonstrate how these CAC policies and ALC represent progressive steps in developing optimal CAC policies for calls with exponentially distributed call holding times, and extend this process to the more general case of calls with IFR call holding times.