Software Optimization in Ultrasound Imaging Technique Using Improved Deep Belief Learning Network on the Internet of Medical Things Platform

Wireless Personal Communications - The Internet of Medical Things (IoMT) is the array of medical instruments and related technologies that link Information Technology (IT) systems in...     

Advanced Glycation End-Products Enhance Lung Cancer Cell Invasion and Migration

Effects of carboxymethyllysine (CML) and pentosidine, two advanced glycation end-products (AGEs), upon invasion and migration in A549 and Calu-6 cells, two non-small cell lung cancer (NSCLC) cell lines were examined. CML or pentosidine at 1, 2, 4, 8 or 16 μmol/L were added into cells. Proliferation, invasion and migration were measured. CML or pentosidine at 4–16 μmol/L promoted invasion and migration in both cell lines, and increased the production of reactive oxygen species, tumor necrosis factor-α, interleukin-6 and transforming growth factor-β1. CML or pentosidine at 2–16 μmol/L up-regulated the protein expression of AGE receptor, p47^phox, intercellular adhesion molecule-1 and fibronectin in test NSCLC cells. Matrix metalloproteinase-2 protein expression in A549 and Calu-6 cells was increased by CML or pentosidine at 4–16 μmol/L. These two AGEs at 2–16 μmol/L enhanced nuclear factor κ-B (NF-κ B) p65 protein expression and p38 phosphorylation in A549 cells. However, CML or pentosidine at 4–16 μmol/L up-regulated NF-κB p65 and p-p38 protein expression in Calu-6 cells. These findings suggest that CML and pentosidine, by promoting the invasion, migration and production of associated factors, benefit NSCLC metastasis.     

Scientific publications by anesthesia departments in East Asia

The rapid economic growth in East Asia might have an impact on the development of research output. Because previous bibliometric analysis about anesthesiology in this region had been limited to research within anesthesiology journals or anesthesia-related research, the total publications from anesthesia departments might not be well displayed. In this study, the databases of Web of Science and PubMed were used to assess the academic productivity and distribution of research diversity of anesthesia departments from four major countries in East Asia and compared those with the USA. From 2001 to 2010 the volume of scientific research from anesthesia departments in East Asia has stably increased. Although Japan was the most productive contributor in East Asia, its share declined annually. China increased most rapidly and exceeded Japan in 2010 in terms of annual number of papers. Research attributed to anesthesia departments in East Asia was diverse and present in a wide range of non-anesthesia field journals. Notably the annual number of randomized controlled trials in East Asia also had a strong growth.