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Chitosan and β-cyclodextrin were used to prepare microspheres with theophylline for pulmonary delivery by spray drying method. The characteristics, mucociliotoxicity, permeation rate and drug release were studied. The drug entrapments of microspheres Ⅰ, Ⅱ and Ⅲ were from 35.70% to 21.09% and 13.33%, while yields and encapsulation efficiencies were higher than 45% and about 90% respectively. The microspheres possessed low tap densities (0.34-0.48 g/cm^3), appropriate diameters (3.35-3.94 μm) and theoretical aerodynamics diameters (2.20-3.04 μm). SEM images showed the microspheres were spherical with smooth or wrinkled surface surfaces. FT-IR demonstrated theophylline had formed hydrogen bonds with chitosan and fl-cyclodextrin. The microspheres could effectively reduce the ciliotoxicity and easy to penetrate the memberine. The in vitro release of the microspheres was related to the ratio of drug/polymer and microspheres Ⅱ had a prolong release, providing the release of 72.00% in 12 h. The results suggestes that chitosan/β-cyclodextrin microspheres Ⅱ are a promising carrier as sustained release for pulmonary delivery. 相似文献
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The properties of biogenic magnetite(Fe 3 O 4 )nanoparticles in chiton acanthochiton rubrolineatus lischke were characterized by selected electron diffractometry,high resolution transmission electron microscopy,Fourier transform infrared spectroscopy,M·ssbauer spectroscopy and magnetization measurements.Results showed that the magnetite nanoparticles presented crystalline appearance,exhibiting strong absorptions at 595,1 463,3 467 cm-1 and weak adsorptions at 1 697,1 113,1 048,848,445 cm-1 in FT-IR,two partially overlapping sextets in M·ssbauer spectrum,and the area ratio of the sextets was 1.08.Also,the particles exhibited ferromagnetic behavior,and had 82 A·m2/kg saturation magnetization,1.4·104 A/m coercive force and 4.0 A·m2/kg remnant magnetization,respectively.The investigation indicates that the biogenic magnetite nanoparticles mineralized in the chiton are impure in composition and non-stoichiometric. 相似文献
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羧甲基壳多糖微载体CX-2的性能研究 总被引:2,自引:1,他引:1
以羧甲基壳多糖(CMCH)为材料,研制出一种用于动物细胞培养的新型微载体CX-2。对该微载体的色泽、干燥失重、比表面积、悬浮密度、直径、吸水量、溶胀度、粒度分布、表面结构、机械强度、稳定性等理化指标进行了测定,结果表明,CX-2是一种性能良好的微载体。细胞学实验表明,BB细胞能较好地黏着于CX-2微载体上,在24~72h期间细胞生长增殖速度快,120h时细胞已呈现多层次生长状态。再生后的CX-2,可继续用于BB细胞培养,效果无明显变化。结果初步表明,CX-2为新型的、适于动物细胞大规模培养的、可再生利用的微载体。 相似文献
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目的优化维生素E(VE)脂质体的制备工艺并考察其性质。方法采用乙醇注入法、乙醚注入法、逆相蒸发法、薄膜水化法和复乳法分别制备v。脂质体,以包封率和保留率为考察指标,选择最优制备方法;经L9(3^4)正交试验设计优化选择,确定脂质体的最佳配方。结果薄膜水化法制备所得的VE脂质体包封率最高,VE保留率较高;用薄膜水化法制备脂质体的最佳配方为磷脂:VE:胆固醇=20:0.8:1.5;用透射电镜观察最佳实验组VE脂质体发现其具有指纹状结构,Zeta电位为.30.9±0.9mV,平均粒径为33.7nm。结论薄膜水化法制得的V。脂质体具有包封率高,VE保留率高,粒径均匀等特点。 相似文献
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