Exposure to virtual nature: the impact of different immersion levels on skin conductance level,heart rate,and perceived relaxation

Virtual Reality - It is generally accepted that natural environments reduce stress and improve mood. Since access to natural environments is sometimes limited, virtual natural environments,...     

Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains

Nonribosomal peptide synthetases (NRPSs) use terminal reductase domains for 2-electron reduction of the enzyme-bound thioester releasing the generated peptides as C-terminal aldehydes. Herein, we reveal the biosynthesis of a pyrazine that originates from an aldehyde-generating minimal NRPS termed ATRed in entomopathogenic Xenorhabdus indica. Reductase domains were also investigated in terms of NRPS engineering and, although no general applicable approach was deduced, we show that they can indeed be used for the production of similar natural and unnatural pyrazinones.     

The periodic system and the idea of a chemical element: From Mendeleev to superheavy elements

Like other scientific concepts, the idea of a chemical element has changed considerably over time, since it was first established in the Enlightenment era. In Dmitri Mendeleev's construction of the periodic system, he distinguished between simple substances and elements as defined by their atomic weights. The foundation of the periodic system on the latter concept led to several challenges. For example, the system seemed unable to accommodate the radioactive substances eventually recognised as isotopes. Around 1920, elements were consequently redefined in terms of their atomic numbers, a nuclear property that could be determined by X‐ray spectroscopy. Although this understanding of an element has stood the test of time, new questions turned up relating to the concept of an element following the syntheses of transuranic elements since the early 1940s. These syntheses of very heavy elements have additionally led chemists and physicists to reconsider the criteria for the discovery of a new element. Recently, elements have been officially recognised on the sole ground that a small number of very heavy atomic nuclei were identified. The paper discusses how the notion of an element was modified during different periods of time, the reasons for the modifications, and the values ascribed to them in the communities of chemists and physicists.     

Phototemtide A,a Cyclic Lipopeptide Heterologously Expressed from Photorhabdus temperata Meg1, Shows Selective Antiprotozoal Activity

A new cyclic lipopeptide, phototemtide A ( 1 ), was isolated from Escherichia coli expressing the biosynthetic gene cluster pttABC from Photorhabdus temperata Meg1. The structure of 1 was elucidated by HR-ESI-MS and NMR experiments. The absolute configurations of amino acids and 3-hydroxyoctanoic acid in 1 were determined by using the advanced Marfey's method and comparison after total synthesis of 1 , respectively. Additionally, three new minor derivatives, phototemtides B–D ( 2 – 4 ), were identified by detailed HPLC–MS analysis. Phototemtide A ( 1 ) showed weak antiprotozoal activity against Plasmodium falciparum, with an IC₅₀ value of 9.8 μm . The biosynthesis of phototemtides A–D ( 1 – 4 ) was also proposed.     

Rapid Determination of the Amino Acid Configuration of Xenotetrapeptide

An E. coli strain with deletions in five transaminases (ΔaspC ΔilvE ΔtyrB ΔavtA ΔybfQ) was constructed to be unable to degrade several amino acids. This strain was used as an expression host for the analysis of the amino acid configuration of nonribosomally synthesized peptides, including the novel peptide “xenotetrapeptide” from Xenorhabdus nematophila, by using a combination of labeling experiments and mass spectrometry. Additionally, the number of D ‐amino acids in the produced peptide was assigned following simple cultivation of the expression strain in D₂O.     

Cultivating the Herb Garden of Scandinavian Mathematics: The Congresses of Scandinavian Mathematicians, 1909–1925

As a reaction to the changed political landscape in Scandinavia following the dissolution of the union between Norway and Sweden in 1905, the prominent Swedish mathematician Gösta Mittag‐Leffler extended ‘a brotherly hand,’ calling for Scandinavian colleagues to meet for a congress of mathematicians in Stockholm in 1909. This event became the first in a series of biannual meetings which proved to be an important institution for Scandinavian mathematics. During the first decades after 1909, the congresses would form and consolidate themselves through the construction of a new Scandinavian identity for mathematicians which developed alongside and in relation to both international and national contexts and developments. In this paper, we shall demonstrate that these meetings served a complex set of agendas at the individual, national, and international level. In particular, they reflect a changing conception of cooperation in science for mutual cultural gain combined with a flexible institutionalisation that allowed the Scandinavian mathematicians to use the congresses for various diplomatic ambitions. We base our analyses of the Scandinavian Congresses of Mathematics on the notion of a shared ‘conational’ identity developed adjacent to national identities. We then analyse the formation, consolidation, delineation, and reflections of this institution in order to demonstrate how the efforts to unite Scandinavian mathematicians were contingent on and influenced by simultaneous currents of internationalisation and shared history, culture, and language in the Scandinavian region.