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排序方式: 共有1397条查询结果,搜索用时 125 毫秒
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2.
Marta Gabasa Marselina Arshakyan Alejandro Llorente Lourdes Chuli-Peris Irina Pavelescu Antoni Xaubet Javier Pereda Jordi Alcaraz 《International journal of molecular sciences》2020,21(22)
Pro-inflammatory cytokines like interleukin-1β (IL-1β) are upregulated during early responses to tissue damage and are expected to transiently compromise the mechanical microenvironment. Fibroblasts are key regulators of tissue mechanics in the lungs and other organs. However, the effects of IL-1β on fibroblast mechanics and functions remain unclear. Here we treated human pulmonary fibroblasts from control donors with IL-1β and used Atomic Force Microscopy to unveil that IL-1β significantly reduces the stiffness of fibroblasts concomitantly with a downregulation of filamentous actin (F-actin) and alpha-smooth muscle (α-SMA). Likewise, COL1A1 mRNA was reduced, whereas that of collagenases MMP1 and MMP2 were upregulated, favoring a reduction of type-I collagen. These mechanobiology changes were functionally associated with reduced proliferation and enhanced migration upon IL-1β stimulation, which could facilitate lung repair by drawing fibroblasts to sites of tissue damage. Our observations reveal that IL-1β may reduce local tissue rigidity by acting both intracellularly and extracellularly through the downregulation of fibroblast contractility and type I collagen deposition, respectively. These IL-1β-dependent mechanical effects may enhance lung repair further by locally increasing pulmonary tissue compliance to preserve normal lung distension and function. Moreover, our results support that IL-1β provides innate anti-fibrotic protection that may be relevant during the early stages of lung repair. 相似文献
3.
Konstantin V. Dergilev Evgeny K. Shevchenko Zoya I. Tsokolaeva Irina B. Beloglazova Ekaterina S. Zubkova Maria A. Boldyreva Mikhail Yu. Menshikov Elizaveta I. Ratner Dmitry Penkov Yelena V. Parfyonova 《International journal of molecular sciences》2020,21(24)
Cell therapy of the post-infarcted myocardium is still far from clinical use. Poor survival of transplanted cells, insufficient regeneration, and replacement of the damaged tissue limit the potential of currently available cell-based techniques. In this study, we generated a multilayered construct from adipose-derived mesenchymal stromal cells (MSCs) modified to secrete stem cell factor, SCF. In a rat model of myocardium infarction, we show that transplantation of SCF producing cell sheet induced activation of the epicardium and promoted the accumulation of c-kit positive cells in ischemic muscle. Morphometry showed the reduction of infarct size (16%) and a left ventricle expansion index (0.12) in the treatment group compared to controls (24–28%; 0.17–0.32). The ratio of viable myocardium was more than 1.5-fold higher, reaching 49% compared to the control (28%) or unmodified cell sheet group (30%). Finally, by day 30 after myocardium infarction, SCF-producing cell sheet transplantation increased left ventricle ejection fraction from 37% in the control sham-operated group to 53%. Our results suggest that, combining the genetic modification of MSCs and their assembly into a multilayered construct, we can provide prolonged pleiotropic effects to the damaged heart, induce endogenous regenerative processes, and improve cardiac function. 相似文献
4.
D. G. Pavel’ev N. V. Demarina Yu. I. Koshurinov A. P. Vasil’ev E. S. Semenova A. E. Zhukov V. M. Ustinov 《Semiconductors》2004,38(9):1105-1110
Characteristics of ohmic InGaAs contacts in planar diodes based on semiconductor superlattices with a small-area active region
(1–10 μm2) are studied. The diodes were formed on the basis of short (18 or 30 periods) heavily doped (1018 cm−3) GaAs/AlAs superlattices with a miniband width of 24.4 meV. The reduced resistance of the ohmic contact was equal to 2×10−7 Ω cm2 at room temperature. It is shown that the properties of fabricated planar diodes make it possible to use these diodes later
on in semiconductor devices that operate in the terahertz frequency region in a wide temperature range (4–300 K).
__________
Translated from Fizika i Tekhnika Poluprovodnikov, Vol. 38, No. 9, 2004, pp. 1141–1146.
Original Russian Text Copyright ? 2004 by Pavel’ev, Demarina, Koshurinov, Vasil’ev, Semenova, Zhukov, Ustinov. 相似文献
5.
L. G. Gerchikov Yu. A. Mamaev A. V. Subashiev Yu. P. Yashin D. A. Vasil’ev V. V. Kuz’michev A. E. Zhukov E. S. Semenova A. P. Vasil’ev V. M. Ustinov 《Semiconductors》2006,40(11):1326-1332
Photoemission of polarized electrons from heterostructures based on InAlGaAs/GaAs superlattices with minimum conduction-band offsets is investigated. The comparison of the excitation energy dependence of the photoemission polarization degree with the calculated spectra make it possible to determine the polarization losses at different stages of the photoemission. A maximum polarization of P = 91% and a quantum yield of 0.14% are close to the best results obtained for photocathodes on the basis of strained semiconductor superlattices. 相似文献
6.
Felix Rivkin Irina Kuznetsova Nadezhda Ivanova Sergey Suhodolsky 《Soil Mechanics and Foundation Engineering》2002,39(1):42-43
Soil Mechanics and Foundation Engineering - 相似文献
7.
A. N. Gudkov V. M. Zhivun A. V. Zvonarev V. V. Kovalenko A. B. Koldobskii Yu. F. Koleganov S. V. Krivasheev V. B. Pavlovich N. S. Piven' E. V. Semenova 《Atomic Energy》1989,66(2):115-118
Translated from Atomnaya Énergiya, Vol. 66, No. 2, pp. 100–103, February, 1989. 相似文献
8.
L. Ya. Karachinsky T. Kettler N. Yu. Gordeev I. I. Novikov M. V. Maximov Yu. M. Shernyakov N. V. Kryzhanovskaya A. E. Zhukov E. S. Semenova A. P. Vasil’ev V. M. Ustinov N. N. Ledentsov A. R. Kovsh V. A. Shchukin S. S. Mikhrin A. Lochmann O. Schulz L. Reissmann D. Bimberg 《Semiconductors》2005,39(12):1415-1419
Lasers based on InAs/InGaAs quantum dots grown on metamorphic (In,Ga,Al)As layers deposited by MBE on GaAs substrates exhibited emission near 1.5 μm with a differential quantum efficiency of about 50%. The narrow-stripe lasers operate in a single transverse mode and withstand continuous current density above 20 kA cm?2 without significant degradation. A maximum continuous-wave output power of 220 mW is obtained. Neither current nor beam filamentation was observed up to the highest pumping levels. 相似文献
9.
The authors propose an approach to solving problems of deformation of nonsymmetrically loaded shells of revolution whose boundary contours are supported in the general case at individual points. The problem is substituted by a problem with the boundary conditions of the same type around the entire contour which contain unknown parameters determined from the condition of converting to zero the displacements at the support points. Consequently, the problem is reduced to integrating systems of conventional differential equations and solving a system of algebraic equations. The solution of a problem of the stressed state of a hyperbolic shell, supported at four points at the contour, is presented.
Translated from Problemy Prochnosti, No. 8, pp. 31–35, August, 1992. 相似文献
10.
The standard impact factor as an evaluation tool of science fields and scientific journals 总被引:2,自引:2,他引:0
Irina Marshakova-Shaikevich 《Scientometrics》1996,35(2):283-290
The standard impact factor for particular fields of science (Ig) and the relative impact factor K for scientific journals are introduced. The technique of calculation of standard impact factor (Ig) for a field is an inherent part of a method which allows a cross-field evaluation of scientific journals. This method for evaluating scientific journals elaborated in 1988 was aimed at the analysis of Russian journals covered by the SCI database, it was also used for chemical journals (more that 300) and for journals in the Life sciences (more than 1000). The results are discussed. 相似文献