C105管桩混凝土设计参数取值的探讨

通过试验得出了C105混凝土100 mm×100 mm×100 mm立方体非标准试件抗压强度换算系数以及C105混凝土的标准方差和强度变异系数。采用理论计算,得到了棱柱体抗压强度与立方体抗压强度的比值α_c1,并与试验实测平均值进行了比较,验证了理论计算方法的可行性。此外,通过对比分析,探讨了直接外延法和引用公式法两种C105混凝土设计参数计算方法的正确性,研究结果可为C105管桩混凝土的设计和应用提供参考。     

An Improved Approach for Spatial and Temporal Individual Risk Assessment Considering Synergistic Effects of Multiple Fires Occurred Sequentially

Fire Technology - The current research on individual risks mainly focuses on the individual risk considering a single fire or the spatial distribution of multiple fires. It is more realistic to...     

Adaptive Graph Learning for Semi-supervised Self-paced Classification

Neural Processing Letters - Semi-supervised learning techniques have been attracting increasing interests in many machine learning fields for its effectiveness in using labeled and unlabeled...     

Two Methods,One Goal: Structural Differences between Cocrystallization and Crystal Soaking to Discover Ligand Binding Poses

In lead optimization, protein crystallography is an indispensable tool to analyze drug binding. Binding modes and non-covalent interaction inventories are essential to design follow-up synthesis candidates. Two protocols are commonly applied to produce protein–ligand complexes: cocrystallization and soaking. Because of its time and cost effectiveness, soaking is the more popular method. Taking eight ligand hinge binders of protein kinase A, we demonstrate that cocrystallization is superior. Particularly for flexible proteins, such as kinases, and larger ligands cocrystallization captures more reliable the correct binding pose and induced protein adaptations. The geometrical discrepancies between soaking and cocrystallization appear smaller for fragment-sized ligands. For larger flexible ligands that trigger conformational changes of the protein, soaking can be misleading and underestimates the number of possible polar interactions due to inadequate, highly impaired positions of protein amino-acid side and main chain atoms. Thus, if applicable cocrystallization should be the gold standard to study protein–ligand complexes.     

静水压力释放技术在地下工程中的应用

CMC静水压力释放技术具备解决新建及既有建筑物基底浮力问题的能力,主要适用于透水层为黏性土、粉性土的土层.广州某工程基础底板处于微风化砂岩中,针对岩层透水性弱的特点,基于CMC静水压力释放技术原理,分析各技术节点要求,并考虑安全性、经济性、绿色施工,提出关键技术措施,形成了一整套适用于岩层的新型深大地下结构工程静水释放施工工艺.通过实际应用,对关键施工工序进行介绍.实践结果表明,该技术的应用取得了良好的经济和社会效益.     

综合设计性实验在药物分析学实验中对学生综合能力的培养

《药物分析学实验》是药学专业的一门独立必修课程,是药学科学领域中的一个重要组成部分,具有较强的实践性和综合性,旨在培养学生综合运用所学知识分析药品质量的能力.综合设计性实验作为《药物分析学实验》的重要组成部分,对学生实践操作能力,发现问题、分析问题、解决问题的能力,创新能力,应用能力,团结协作能力,劳动素养等综合能力的培养具有极其重要的意义.     

A robust watermarking approach for security issue of binary documents using fully convolutional networks

International Journal on Document Analysis and Recognition (IJDAR) - Motivated by increasing possibility of the tampering of genuine documents during a transmission over digital channels, we focus...