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1.
Mariana Tasso Thomas Pons Nicolas Lequeux Julie Nguyen Zsolt Lenkei Diana Zala 《Small (Weinheim an der Bergstrasse, Germany)》2019,15(47)
Single‐particle tracking with quantum dots (QDs) constitutes a powerful tool to track the nanoscopic dynamics of individual cell membrane components unveiling their membrane diffusion characteristics. Here, the nano‐resolved population dynamics of QDs is exploited to reconstruct the topography and structural changes of the cell membrane surface with high temporal and spatial resolution. For this proof‐of‐concept study, bright, small, and stable biofunctional QD nanoconstructs are utilized recognizing the endogenous neuronal cannabinoid receptor 1, a highly expressed and fast‐diffusing membrane protein, together with a commercial point‐localization microscope. Rapid QD diffusion on the axonal plasma membrane of cultured hippocampal neurons allows precise reconstruction of the membrane surface in less than 1 min with a spatial resolution of tens of nanometers. Access of the QD nanoconstructs to the synaptic cleft enables rapid 3D topological reconstruction of the entire presynaptic component. Successful reconstruction of membrane nano‐topology and deformation at the second time‐scale is also demonstrated for HEK293 cell filopodia and axons. Named “nanoPaint,” this super‐resolution imaging technique amenable to any endogenous transmembrane target represents a versatile platform to rapidly and accurately reconstruct the cell membrane nano‐topography, thereby enabling the study of the rapid dynamic phenomena involved in neuronal membrane plasticity. 相似文献
2.
Dr. Lilia Clima Bogdan Florin Craciun Dr. Andrea Angeli Andrea Petreni Alessandro Bonardi Dr. Alessio Nocentini Dr. Fabrizio Carta Prof. Paola Gratteri Prof. Mariana Pinteala Prof. Claudiu T. Supuran 《ChemMedChem》2020,15(21):2052-2057
We report novel molecules incorporating the nontoxic squalene scaffold and different carbonic anhydrase inhibitors (CAIs). Potent inhibitory action, in the low-nanomolar range, was detected against isoforms hCA II for sulfonamide derivatives, which proved to be selective against this isoform over the tumor-associate hCA IX and XII isoforms. On the other hand, coumarin derivatives showed weak potency but high selectivity against the tumor-associated isoform CA IX. These compounds are interesting candidates for preclinical evaluation in glaucoma or various tumors in which the two enzymes are involved. In addition, an in silico study of inhibitor-bound hCA II revealed extensive interactions with the hydrophobic pocket of the active site and provided molecular insights into the binding properties of these new inhibitors. 相似文献
3.
María Clara Verdi Constanza Melian Patricia Castellano Graciela Vignolo Mariana Blanco Massani 《International Journal of Food Science & Technology》2020,55(1):267-275
The effectiveness of antimicrobial mixtures against Listeria innocua 7, used as a L. monocytogenes surrogate, was investigated in broth and a food system. Synergistic effects were found for nisin (Nis), potassium sorbate (PS), calcium propionate (CP) and sodium lactate (SL), Nis + PS being the most effective binary mixture that exhibited listericidal activity in broth. To assess the effect of adding lactocin AL705 (AL705) to Nis + organic acid salt combinations, tridimensional isobolograms were generated. Sub-MIC combinations of the antimicrobials exerted bactericidal activity against L. innocua 7 after AL705 addition to the binary mixtures. However, when applied on Sardo cheese contaminated with L. innocua 7 (initial inoculum 4.45 ± 0.06 CFU g−1), only Nis + PS + AL705 produced count reductions respect to the control, reaching 3.04 ± 0.35 CFU g−1 counts after 15 days at 15 °C. Ternary combinations containing AL705 showed potential to reduce antimicrobial usages for L. innocua 7 inhibition. 相似文献
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5.
Lissy Z. F. Gross Mariana Sacerdoti Prof. Albrecht Piiper Prof. Stefan Zeuzem Dr. Alejandro E. Leroux Dr. Ricardo M. Biondi 《ChemMedChem》2020,15(18):1682-1690
Angiotensin converting enzyme 2 (ACE2) is the human receptor that interacts with the spike protein of coronaviruses, including the one that produced the 2020 coronavirus pandemic (COVID-19). Thus, ACE2 is a potential target for drugs that disrupt the interaction of human cells with SARS-CoV-2 to abolish infection. There is also interest in drugs that inhibit or activate ACE2, that is, for cardiovascular disorders or colitis. Compounds binding at alternative sites could allosterically affect the interaction with the spike protein. Herein, we review biochemical, chemical biology, and structural information on ACE2, including the recent cryoEM structures of full-length ACE2. We conclude that ACE2 is very dynamic and that allosteric drugs could be developed to target ACE2. At the time of the 2020 pandemic, we suggest that available ACE2 inhibitors or activators in advanced development should be tested for their ability to allosterically displace the interaction between ACE2 and the spike protein. 相似文献
6.
Mariana S. Araujo Antonio C. Silva José F. Bartolomé Sonia Mello-Castanho 《Journal of the American Ceramic Society》2020,103(6):3620-3630
The present research exposes the influence of 2 mol% of Al2O3 and 2 mol% SrO in 45S5 Bioglass®-based compositions. Four compositions were produced to elucidate the difference in how both oxides influence structure and thermal behavior separately and their synergy when together. Thermal properties, crystallization tendency, and sintering behavior was evaluated by differential scanning calorimetry, hot stage microscopy, and dilatometry. Changes of medium-range structures were characterized by Qn distribution of Raman spectroscopy and evaluation of 31P, 27Al, 23Na, and 29Si environment obtained by magic angle spinning nuclear magnetic resonance. Despite Qn distribution was predominantly Q2 in all samples, the composition criteria used enabled improved processing and stabilibity characteristics. The addition of Al2O3 and SrO promoted larger sinterability parameter (Sc) which indicates better sintering behavior, the glass stability against crystallization doubled (KH) compared to 45S5 and the processing window enlarged from 106 to 171. 相似文献
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9.
Zachary Freudenburg Khaterah Kohneshin Erik Aarnoutse Mariska Vansteensel Mariana Branco Sacha Leinders Max van den Boom Elmar G. M. Pels Nick Ramsey 《控制理论与应用(英文版)》2021,19(4):444-454
While brain computer interfaces (BCIs) offer the potential of allowing those suffering from loss of muscle control to once
again fully engage with their environment by bypassing the affected motor system and decoding user intentions directly from
brain activity, they are prone to errors. One possible avenue for BCI performance improvement is to detect when the BCI user
perceives the BCI to have made an unintended action and thus take corrective actions. Error-related potentials (ErrPs) are
neural correlates of error awareness and as such can provide an indication of when a BCI system is not performing according
to the user’s intentions. Here, we investigate the brain signals of an implanted BCI user suffering from locked-in syndrome
(LIS) due to late-stage ALS that prevents her from being able to speak or move but not from using her BCI at home on a
daily basis to communicate, for the presence of error-related signals. We first establish the presence of an ErrP originating
from the dorsolateral pre-frontal cortex (dLPFC) in response to errors made during a discrete feedback task that mimics the
click-based spelling software she uses to communicate. Then, we show that this ErrP can also be elicited by cursor movement
errors in a continuous BCI cursor control task. This work represents a first step toward detecting ErrPs during the daily
home use of a communications BCI. 相似文献
10.
Mariana Fatobene Ando Sindy Fuhrmann Zhiwen Pan Bruno Poletto Rodrigues Tatsuya Mori Stefan G. Ebbinghaus Katrin Wondraczek Suguru Kitani Lothar Wondraczek 《Journal of the American Ceramic Society》2021,104(10):4991-5000
We use low-temperature heat capacity, low-frequency Raman scattering, and THz time domain spectroscopy in order to scale the vibrational density of states and the Boson peak in SiO2-Al2O3-B2O3 Yb-laser host glasses. When substituting B2O3 for SiO2 at constant Al2O3 dopant level, we find an optimal value for the ratio of B/Al in terms of mixture stability, at which the excess in the electron donor capability of Al2O3 (relative to the SiO2 backbone) is compensated by the more acidic B2O3. At this composition, Al2O3 plays a mediating role in the structure of aluminoborosilicate glasses, facilitating dissolution of Yb2O3 and admixture of B2O3 into the SiO2 network. 相似文献