Sources and dynamics of semivolatile organic compounds in a single‐family residence in northern California

Semivolatile organic compounds (SVOCs) emitted from building materials, consumer products, and occupant activities alter the composition of air in residences where people spend most of their time. Exposures to specific SVOCs potentially pose risks to human health. However, little is known about the chemical complexity, total burden, and dynamic behavior of SVOCs in residential environments. Furthermore, little is known about the influence of human occupancy on the emissions and fates of SVOCs in residential air. Here, we present the first‐ever hourly measurements of airborne SVOCs in a residence during normal occupancy. We employ state‐of‐the‐art semivolatile thermal‐desorption aerosol gas chromatography (SV‐TAG). Indoor air is shown consistently to contain much higher levels of SVOCs than outdoors, in terms of both abundance and chemical complexity. Time‐series data are characterized by temperature‐dependent elevated background levels for a broad suite of chemicals, underlining the importance of continuous emissions from static indoor sources. Substantial increases in SVOC concentrations were associated with episodic occupant activities, especially cooking and cleaning. The number of occupants within the residence showed little influence on the total airborne SVOC concentration. Enhanced ventilation was effective in reducing SVOCs in indoor air, but only temporarily; SVOCs recovered to previous levels within hours.     

25CN-NBOH: A Selective Agonist for in vitro and in vivo Investigations of the Serotonin 2A Receptor

4-(2-((2-hydroxybenzyl)amino)ethyl)-2,5-dimethoxybenzonitrile (25CN-NBOH) was first reported as a potent and selective serotonin 2A receptor (5-HT_2AR) agonist in 2014, and it has since found extensive use as a pharmacological tool in a variety of in vitro, ex vivo and in vivo studies. 25CN-NBOH is readily available from a synthetic perspective using standard chemical transformations, and displays favorable physiochemical properties in terms of stability and solubility. Due to its superior selectivity for 5-HT_2AR, 25CN-NBOH has been used to investigate the effects of selective 5-HT_2AR activation in vivo, and has thus become an important pharmacological tool for the exploration of 5-HT_2AR signaling in a range of animal models. In the present review, we outline the discovery of 25CN-NBOH, its pharmacological profile and major findings from studies where it has been used.     

Indoor emissions of total and fluorescent supermicron particles during HOMEChem

Inhalation of particulate matter is associated with adverse health outcomes. The fluorescent portion of supermicron particulate matter has been used as a proxy for bioaerosols. The sources and emission rates of fluorescent particles in residential environments are not well-understood. Using an ultraviolet aerodynamic particle sizer (UVAPS), emissions of total and fluorescent supermicron particles from common human activities were investigated during the HOMEChem campaign, a test-house investigation of the chemistry of indoor environments. Human occupancy and activities, including cooking and mopping, were found to be considerable sources of indoor supermicron fluorescent particles, which enhanced the indoor particle concentrations by two orders of magnitude above baseline levels. The estimated total (fluorescent) mass emission rates for the activities tested were in the range of 4-30 (1-11) mg per person meal for cooking and 0.1-4.9 (0.05-4.7) mg/h for occupancy and mopping. Model calculations indicate that, once released, the dominant fate of coarse particles (2.5-10 micrometer in diameter) was deposition onto indoor surfaces, allowing for the possibility of subsequent resuspension and consequent exposures over durations much longer than the ventilation time scale. Indoor coarse particle deposition would also contribute to soiling of indoor surfaces.     

炮采放顶煤工作面采空区顶板抽放瓦斯实践

文章介绍了高瓦斯炮采放顶煤工作面采空区煤层顶板抽放瓦斯的实践,通过对钻场中钻孔抽放过程的跟踪测试、观察、归纳分析,总结出提高瓦斯抽放效率的最佳顶板裂隙带高度,并对关键性技术要点和裂隙带高度的确定提供了理论判定方法。     

基于三维漏磁测量的腐蚀检测探头设计

在传统一维漏磁检测的基础上,为了获取更多特征信息以提高漏磁检测对缺陷的识别能力,提出了三维漏磁检测新方法.较传统一维检测,三维漏磁检测对信号采集系统有着更高的要求,本文适时提出了一种适应三维漏磁检测的磁场测量探头的设计方案,并已经在实验现场得到应用.     

血管紧张素(1-7)的神经活性研究进展

血管紧张素(1-7)［angiotensin(1-7),Ang(1-7)］通过肾素-血管紧张素系统(renin-angiotensin system,RAS)新的作用分支血管紧张素转化酶2(angiotensin-converting enzyme 2,ACE2)-血管紧张素(1-7)-Mas受体(ACE2-Ang(1-7)-Mas)轴反向调节经典ACE-AngII-AT受体轴。Ang(1-7)广泛存在于下丘脑视上核和室旁核,可以通过缓激肽、一氧化氮合酶(NOS)、环氧合酶(COX)及一些信号通路影响其他中枢神经递质的合成及释放,发挥扩张血管、抗心律失常、抗炎等作用,达到保护心血管及中枢神经系统的效果。本文就Ang(1-7)的分布及在中枢神经系统中多样性的生物功能作一综述。     

旋转导向钻井系统中振动加速度的消除方法

在钻井过程中,钻头切削岩层、钻柱与井壁的碰撞,必然造成钻井工具的振动,这些振动会在测斜加速度传感器的输出上得到反映,使其不能真实地反映井眼姿态的变化。为及时得到准确的井眼姿态,有必要研究振动条件下传感器的输出规律,进而消除振动的影响。从室内模拟振动实验的原始数据入手,通过Matlab对传感器输出信号进行功率谱密度估计,得出了振动频率与转速的大致关系,并设计了具有针对性的滤波器。通过对实验数据分析处理,振动干扰信号的能量得到大幅衰减,测斜传感器3个敏感轴的输出波动明显减小,提高了姿态测量的准确性,从而验证了该方法在旋转导向系统中是可行的。     

Future Scenarios: What are the Future Services and Applications?

With the change of paradigm within user-machine interaction, there is an increasing demand for seamless interoperability between different technologies as well as more intuitive ways of utilizing the applications on the devices. This implies that the underlying technologies must support the appropriate bandwidth, mobility and quality at the right cost in order for the end-user to perceive the infrastructure appropriate for the services and corresponding applications of the future. In addition, it is required that interoperability will be realized at the semantic level and not just the syntactical level. The purpose of the paper is to present the authors’ thoughts of a new Information and Communication Technology paradigm and to highlight what might have an impact on the realization/deployment of such a paradigm.