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排序方式: 共有3725条查询结果,搜索用时 31 毫秒
1.
Parul Singh Arun Rawat Bara Al-Jarrah Saras Saraswathi Hoda Gad Mamoun Elawad Khalid Hussain Mohammed A. Hendaus Wesam Al-Masri Rayaz A. Malik Souhaila Al Khodor Anthony K. Akobeng 《International journal of molecular sciences》2021,22(4)
Coeliac disease (CD) and Type 1 diabetes mellitus (T1DM) are immune-mediated diseases. Emerging evidence suggests that dysbiosis in the gut microbiome plays a role in the pathogenesis of both diseases and may also be associated with the development of neuropathy. The primary goal in this cross-sectional pilot study was to identify whether there are distinct gut microbiota alterations in children with CD (n = 19), T1DM (n = 18) and both CD and T1DM (n = 9) compared to healthy controls (n = 12). Our second goal was to explore the relationship between neuropathy (corneal nerve fiber damage) and the gut microbiome composition. Microbiota composition was determined by 16S rRNA gene sequencing. Corneal confocal microscopy was used to determine nerve fiber damage. There was a significant difference in the overall microbial diversity between the four groups with healthy controls having a greater microbial diversity as compared to the patients. The abundance of pathogenic proteobacteria Shigella and E. coli were significantly higher in CD patients. Differential abundance analysis showed that several bacterial amplicon sequence variants (ASVs) distinguished CD from T1DM. The tissue transglutaminase antibody correlated significantly with a decrease in gut microbial diversity. Furthermore, the Bacteroidetes phylum, specifically the genus Parabacteroides was significantly correlated with corneal nerve fiber loss in the subjects with neuropathic damage belonging to the diseased groups. We conclude that disease-specific gut microbial features traceable down to the ASV level distinguish children with CD from T1DM and specific gut microbial signatures may be associated with small fiber neuropathy. Further research on the mechanisms linking altered microbial diversity with neuropathy are warranted. 相似文献
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Premnath Kumar Arun Prasad Murthy Leticia S. Bezerra Bibiana K. Martini Gilberto Maia Jagannathan Madhavan 《International Journal of Hydrogen Energy》2021,46(1):622-632
Hydrogen production through water splitting is an efficient and green technology for fulfilling future energy demands. Carbon nanotubes (CNT) supported Ni2P has been synthesized through a simpler hydrothermal method. Ni2P/CNT has been employed as efficient electrocatalysts for hydrogen and oxygen evolution reactions in acidic and alkaline media respectively. The electrocatalyst has exhibited low overpotential of 137 and 360 mV for hydrogen and oxygen evolution reactions respectively at 10 mA cm?2. Lower Tafel slopes, improved electrochemical active surface area, enhanced stability have also been observed. Advantages of carbon support in terms of activity and stability have been described by comparing with unsupported electrocatalyst. 相似文献
3.
Srinivasan Deepasree Murugesan Arun 《Bulletin of Engineering Geology and the Environment》2022,81(8):1-15
Bulletin of Engineering Geology and the Environment - The pavements of the Beijing Capital International Airport (BCIA), China, where a buried fault zone lies beneath, have undergone continuous... 相似文献
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Sarkar Manas Mishra Shivangi Daniel Anitha Dwari Santanu 《Wireless Personal Communications》2019,104(1):269-286
Wireless Personal Communications - This paper presents a study of a class of iris localization algorithms in the presence of blurring. The effect of blurring is a serious problem in most image... 相似文献
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Wireless Personal Communications - Complementary coded code-division multiple access (CC-CDMA) has been originated as one of the extremely robust multiuser access technique in designing high data... 相似文献
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In multicriteria decision-making (MCDM), the existing aggregation operators are mostly based on algebraic t-conorm and t-norm. But, Archimedean t-conorms and t-norms are the generalized forms of t-conorms and t-norms which include algebraic, Einstein, Hamacher, Frank, and other types of t-conorms and t-norms. From that view point, in this paper the concepts of Archimedean t-conorm and t-norm are introduced to aggregate Pythagorean hesitant fuzzy information. Some new operational laws for Pythagorean hesitant fuzzy numbers based on Archimedean t-conorm and t-norm have been proposed. Using those operational laws, Archimedean t-conorm and t-norm-based Pythagorean hesitant fuzzy weighted averaging operator and weighted geometric operator are developed. Some of their desirable properties have also been investigated. Afterwards, these operators are applied to solve MCDM problems in Pythagorean hesitant fuzzy environment. The developed Archimedean aggregation operators are also applicable in Pythagorean fuzzy contexts also. To demonstrate the validity, practicality, and effectiveness of the proposed method, a practical problem is considered, solved, and compared with other existing method. 相似文献
8.
Recently, many researchers have concentrated on distant supervision relation extraction (DSRE). DSRE has solved the problem of the lack of data for supervised learning, however, the data automatically labeled by DSRE has a serious problem, which is class imbalance. The data from the majority class obviously dominates the dataset, in this case, most neural network classifiers will have a strong bias towards the majority class, so they cannot correctly classify the minority class. Studies have shown that the degree of separability between classes greatly determines the performance of imbalanced data. Therefore, in this paper we propose a novel model, which combines class-to-class separability and cost-sensitive learning to adjust the maximum reachable cost of misclassification, thus improving the performance of imbalanced data sets under distant supervision. Experiments have shown that our method is more effective for DSRE than baseline methods. 相似文献
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