Optimized capacitive active ripple compensation topology for a 3.7 kW single-phase high power density on-board charger of electric vehicles

Electrical Engineering - In this paper, a comprehensive investigation of the capacitive active ripple compensation (ARC) techniques is made to conclude which one is optimal to be used in on-board...     

Experimental investigations and constitutive modeling of cyclic interface shearing between HDPE geomembrane and sandy gravel

This paper presents the results of experimental investigations and constitutive modeling of cyclic interface shearing between HDPE geomembrane and cohesionless sandy gravel. A series of cyclic interface shear tests was performed using a large-scale cyclic shear apparatus with servo controlled system. Particular attention was paid to the influences of the amount of shear-displacement amplitude, number of cycles, shear rate and the normal pressure on the mechanical response. The experimental results show that the path of the shear stress against the cyclic shear displacement is strongly non-linear and forms a closed hysteresis loop, which is pressure dependent, but almost independent of the shear rate. For small shear-displacement amplitudes, the obtained damping ratio is significantly greater than zero, which is different to the behavior usually observed for cyclic soil to soil shearing. In order to describe the pressure dependency of the hysteresis loop using a single set of constitutive parameters, new approximation functions are put forward and embedded into the concept of the Masing rule. Further, a new empirical function is proposed for the damping ratios to capture the experimental data for both small and large cyclic shear-displacement amplitudes. The included model parameters are easy to calibrate and the new functions may also be useful in developing enhanced constitutive models for the simulation of the cyclic interface shear behavior between other geosynthetics and soils.     

Trans-Splicing Improvement by the Combined Application of Antisense Strategies

Spliceosome-mediated RNA trans-splicing has become an emergent tool for the repair of mutated pre-mRNAs in the treatment of genetic diseases. RNA trans-splicing molecules (RTMs) are designed to induce a specific trans-splicing reaction via a binding domain for a respective target pre-mRNA region. A previously established reporter-based screening system allows us to analyze the impact of various factors on the RTM trans-splicing efficiency in vitro. Using this system, we are further able to investigate the potential of antisense RNAs (AS RNAs), presuming to improve the trans-splicing efficiency of a selected RTM, specific for intron 102 of COL7A1. Mutations in the COL7A1 gene underlie the dystrophic subtype of the skin blistering disease epidermolysis bullosa (DEB). We have shown that co-transfections of the RTM and a selected AS RNA, interfering with competitive splicing elements on a COL7A1-minigene (COL7A1-MG), lead to a significant increase of the RNA trans-splicing efficiency. Thereby, accurate trans-splicing between the RTM and the COL7A1-MG is represented by the restoration of full-length green fluorescent protein GFP on mRNA and protein level. This mechanism can be crucial for the improvement of an RTM-mediated correction, especially in cases where a high trans-splicing efficiency is required.     

Power-to-X im Kontext der Energiewende und des Klimaschutzes in Deutschland

In order to examine the impact of different Power-to-X technologies on the transformation of the German energy system and meeting the climate change mitigation goals, a cross-sectoral energy system model was developed. The results show that Power-to-X will be essential for a successful energy transition. Especially in applications where high energy densities are required and only few other options for defossilization exist, Power-to-X technologies become essential.     

Double-Headed Cationic Lipopeptides: An Emerging Class of Antimicrobials

Antimicrobial peptides (AMPs) constitute a promising tool in the development of novel therapeutic agents useful in a wide range of bacterial and fungal infections. Among the modifications improving pharmacokinetic and pharmacodynamic characteristics of natural AMPs, an important role is played by lipidation. This study focuses on the newly designed and synthesized lipopeptides containing multiple Lys residues or their shorter homologues with palmitic acid (C₁₆) attached to the side chain of a residue located in the center of the peptide sequence. The approach resulted in the development of lipopeptides representing a model of surfactants with two polar headgroups. The aim of this study is to explain how variations in the length of the peptide chain or the hydrocarbon side chain of an amino acid residue modified with C₁₆, affect biological functions of lipopeptides, their self-assembling propensity, and their mode of action.     

PAH fluxes in the Laja Lake of south central Chile Andes over the last 50 years: evidence from a dated sediment core

This paper reports the occurrence of polyaromatic hydrocarbons (PAHs) deposition inferred from a sediment core of an Andean lake in south central Chile. Sediments were carefully collected from one of the deepest section of the lake and sliced every 1 cm. The samples were analyzed for PAHs, (137)Cs, (210)Pb, organic carbon and grain-size. The stratigraphic chronology and the sedimentation rates were estimated using the sedimentary signature left by the (137)Cs and (210)Pb fallout as temporal markers. PAHs were quantified by HPLC-fluorescence detection (HPLC-Fluorescence). 15 priority EPA PAHs were analyzed in this study. Based on these results, PAH deposition over the last 50 years was estimated (a period characterized by an important intervention in the area). PAH concentration ranged from 226 to 620 ng g(-1) d.w. The highest concentrations of PAHs were found in the core's bottom. The PAH profile is dominated by the presence of perylene indicating a natural source of PAH. In addition, two clear PAH deposition periods could be determined: the most recent with two-four rings PAHs, the older one with five-seven rings predomination. Determined fluxes where 71 to 972 microg m(-2) year(-1), dominated by perylene deposition. PAH levels and fluxes are lower compared to the levels found in sediments from remote lakes in Europe and North America. It is concluded that the main source of PAHs into the Laja Lake sediments are of natural origin.     

Model based prognosis of contaminant leaching for reuse of demolition waste in construction projects

In this study, groundwater contamination from recycled demolitian waste in road constructions is assessed using predictions of leachate concentrations. Numerical transport simulations are performed for three scenarios (a parking lot, a noise protection barrier, and road), and using a number of characteristic subsoils of Germany, to estimate the breakthrough of different contaminant classes at the groundwater table. Conservative tracer breakthrough times (BTT) primarily depend on subsoil hydraulic properties, for organic pollutants KOC and subsoil OC are the controlling parameters. Significant concentration reductions from dispersion only occur when source concentrations decrease prior to contaminant breakthrough. If source concentrations remain high for long periods relative to peak BTT, concentration breakthrough is undamped. Accounting for biodegradation reduces breakthrough concentrations significantly. For the “noise protection barrier” and “road” scenarios, capillary barrier effects cause the seepage water to partially bypass the recycling material. Accounting for this bypass flow and spatial averaging across the constructions reduces concentrations by about 30–40?%.     

Fire‐retardant hybrid thermosetting resins from unsaturated polyesters and polysilazanes

This introduces an organic–inorganic thermosetting hybrid resin system based on unsaturated polyester and polysilazanes. It shows the chemical modification of unsaturated polyester structures by end capping to enable the combination of both components. In general, halogen‐free unsaturated polyesters are not fire‐retardant and have to be equipped with additives. Fillers and intumescent additives are preponderantly used in today's fire‐retardant formulations. In contrast to these fire‐retardants, polysilazanes act as ceramizing agents. Polysilazanes are suitable fire‐retardants for resin transfer molding due to their low viscosity. Both burning behavior and glass transition temperature (T_g) are investigated as important application properties. In contrast to state‐of‐the‐art fire‐retardant formulations polysilazane‐based thermosetting hybrid resins burn with high intensity and fast extinction. Therefore, total heat and smoke emission is decreased. The formation of ceramic structures during burning results in high residual mechanical properties and a low mass loss. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 40375.     

Anisotropic deformation for local shape control

Computational Visual Media - We present a novel approach to mesh deformation that enables simple context sensitive manipulation of 3D geometry. The method is based on locally anisotropic...     

A STATISTICAL ATTACK ON THE RUNNING KEY CIPHER

The frequencies of n-graphs, groups of n letters, for n as large as 6 are compiled and used to launch a statistical attack on a running key cipher. Programs written in C++ make the calculations possible. The results of the attack for various values of n are analyzed.