Inherited cardiomyopathies are frequent causes of sudden cardiac death (SCD), especially in young patients. Despite at the autopsy they usually have distinctive microscopic and/or macroscopic diagnostic features, their phenotypes may be mild or ambiguous, possibly leading to misdiagnoses or missed diagnoses. In this review, the main differential diagnoses of hypertrophic cardiomyopathy (e.g., athlete’s heart, idiopathic left ventricular hypertrophy), arrhythmogenic cardiomyopathy (e.g., adipositas cordis, myocarditis) and dilated cardiomyopathy (e.g., acquired forms of dilated cardiomyopathy, left ventricular noncompaction) are discussed. Moreover, the diagnostic issues in SCD victims affected by phenotype-negative hypertrophic cardiomyopathy and the relationship between myocardial bridging and hypertrophic cardiomyopathy are analyzed. Finally, the applications/limits of virtopsy and post-mortem genetic testing in this field are discussed, with particular attention to the issues related to the assessment of the significance of the genetic variants. 相似文献
The extracellular matrix (ECM) is a macromolecular network that can provide biochemical and structural support for cell adhesion and formation. It regulates cell behavior by influencing biochemical and physical cues. It is a dynamic structure whose components are modified, degraded, or deposited during connective tissue development, giving tissues strength and structural integrity. The physical properties of the natural ECM environment control the design of naturally or synthetically derived biomaterials to guide cell function in tissue engineering. Tissue engineering is an important field that explores physical cues of the ECM to produce new viable tissue for medical applications, such as in organ transplant and organ recovery. Understanding how the ECM exerts physical effects on cell behavior, when cells are seeded in synthetic ECM scaffolds, is of utmost importance. Herein we review recent findings in this area that report on cell behaviors in a variety of ECMs with different physical properties, i.e., topology, geometry, dimensionality, stiffness, and tension. 相似文献
Local community detection is a widely used method for identifying groups of nodes starting from seeding nodes. The seed(s) are usually selected either randomly or based only on structural properties of the network. However, in many cases the choice of seed(s) incorporates external knowledge that attaches to these nodes an additional importance for their community. This knowledge, may be derived from an expert on the domain, or may arise from the network’s side information and it constitutes our motivation for the present work; this additional information about the importance of seed(s) can be exploited for detection of better and more relevant communities. We call such biased seed(s), hint(s). Our approach, is to reflect the importance of hints by changing appropriately the network in their vicinity. To the best of our knowledge, no such viewpoint of the seeding nodes in local community detection has been considered before. The aim of this study is to identify a single community which contains the hint(s). Our key contribution is the proposed Hint Enhancement Framework(HEF) that applies a two-step procedure to discover the community of the hint(s): 1) it changes the network by amplifying the hint(s) using re-weighting or re-wiring strategies so as to materialize the bias towards them and 2) it applies local community detection algorithms on the altered network of step 1. We experimentally evaluate HEF in synthetic and real datasets, and demonstrate the positive aspects of the framework in identifying better communities, in comparison with plain local community detection algorithms as well as a global one.
The most prominent challenge associated with offshore horizontal drilling is wellbore stability. In this paper, simulation of in-situ stresses around the wellbore is conducted to study the effects of transient pore pressure on the stability of horizontal wells. The rock mechanical analysis based on finite element technique lead to investigate a unique behavior found in subsea horizontal wells known as transient pore pressure behavior and near wellbore pressure gradients. The results demonstrate that near wellbore pore pressure gradient is only active in rock formations which possess transient pore pressure behavior; therefore, simulated solutions require adjustment to achieve accurate results. 相似文献
In this work, facial thermal infrared images are employed for intoxicated person discrimination. Specifically, the region of the forehead of the face of the sober and the corresponding intoxicated person is used to test if the employed Local Difference Patterns (LDPs) constitute discriminative features. For an intoxicated person, vessels on the forehead become more active so that the intensity of the pixels in this region is affected accordingly. The LDPs employed ignore orientation of the pixels distribution and give emphasis on the first and second norms of the differences as well as the ordered values of the pixels in the employed kernels. The statistics of the LDPs for the drunk person are different from those of the sober one and accordingly drunkenness can be ascertained by comparing the thermal infrared image of the corresponding sober and intoxicated person. Six from the eight LDPs examined to be used as features for drunk identification were proved successful. Their classification success rate was over 73 and up to 85%. The proposed method can be incorporated into a non-invasive inspection commercial system to be used by the police as a first step for intoxicated person detection. Forty one participants in the experiment have contributed to the creation of the unique sober–drunk database which is available on the web and contains over 4.000 images. 相似文献
The Anaerobic digestion model 1 (ADM1) framework can be used to predict fermentative hydrogen production, since the latter is directly related to the acidogenic stage of the anaerobic digestion process. In this study, the ADM1 model framework was used to simulate and predict the process of fermentative hydrogen production from the extractable sugars of sweet sorghum biomass. Kinetic parameters for sugars’ consumption and yield coefficients of acetic, propionic and butyric acid production were estimated using the experimental data obtained from the steady states of a CSTR. Batch experiments were used for kinetic parameter validation. Since the ADM1 does not account for metabolic products such as lactic acid and ethanol that are crucial during the fermentative hydrogen production process, the structure of the model was modified to include lactate and ethanol among the metabolites and to improve the predictions. The modified ADM1 simulated satisfactorily batch experiments although further modifications could be made in order to further improve the predictions for the hydrogenogenic process. 相似文献
A nanoporous metal–organic framework material, exhibiting an IRMOF-1 type crystalline structure, was prepared by following a direct solvothermal synthesis approach, using zinc nitrate and terephthalic acid as precursors and dimethylformamide as solvent, combined with supercritical CO2 activation and vacuum outgassing procedures. A series of advanced characterization methods were employed, including scanning electron microscopy, Fourier-transform infrared radiation spectroscopy and X-ray diffraction, in order to study the morphology, surface chemistry and structure of the IRMOF-1 material directly upon its synthesis. Porosity properties, such as Brunauer–Emmet–Teller (BET) specific area (~520 m2/g) and micropore volume (~0.2 cm3/g), were calculated for the activated sample based on N2 gas sorption data collected at 77 K. The H2 storage performance was preliminary assessed by low-pressure (0–1 bar) H2 gas adsorption and desorption measurements at 77 K. The activated IRMOF-1 material of this study demonstrated a fully reversible H2 sorption behavior combined with an adequate gravimetric H2 uptake relative to its BET specific area, thus achieving a value of ~1 wt.% under close-to-atmospheric pressure conditions. 相似文献