NMDA receptors mediate peripheral chemoreceptor afferent input in the conscious rat

N-methyl-D-aspartate (NMDA) glutamate receptors mediate critical components of cardiorespiratory control in anesthetized animals. The role of NMDA receptors in the ventilatory responses to peripheral and central chemoreceptor stimulation was investigated in conscious, freely behaving rats. Minute ventilation (VE) responses to 10% O2, 5% CO2, and increasing intravenous doses of sodium cyanide were measured in intact rats before and after intravenous administration of the NMDA receptor antagonist MK-801 (3 mg/kg). After MK-801, eupcapnic tidal volume (VT) decreased while frequency increased, resulting in a modest reduction in VE. Inspiratory time (TI) decreased, whereas expiratory time remained unchanged. The VE responses to hypercapnia were qualitatively similar in control and MK-801 conditions, with slight reductions in respiratory drive (VT/TI) after MK-801. In contrast, responses to hypoxia were markedly attenuated after MK-801 and were primarily due to reduced frequency changes, whereas VT was unaffected. Sodium cyanide doses associated with significant VE increases were 5 and 50 microg/kg before and after MK-801, respectively. Thus 1-log shift to the right of individual dose-response curves occurred with MK-801. Selective carotid body denervation reduced VE during hypoxia by 70%, and residual hypoxic ventilatory responses were abolished after MK-801. These findings suggest that, in conscious rats, carotid and other peripheral chemoreceptor-mediated hypoxic ventilatory responses are critically dependent on NMDA receptor activation and that NMDA receptor mechanisms are only modestly involved during hypercapnia.     

A scalable solution to the nearest neighbor search problem through local-search methods on neighbor graphs

Pattern Analysis and Applications - Nearest neighbor search is a powerful abstraction for data access; however, data indexing is troublesome even for approximate indexes. For intrinsically...     

Iridium complexes incorporating coumarin moiety as catalyst photoinitiators: Towards household green LED bulb and halogen lamp irradiation

Household LED bulbs and halogen lamps are used to promote the ring-opening photopolymerization of epoxides in the presence of a new series of iridium(III) complexes (IrCs) exhibiting enhanced visible light absorption properties through the introduction of a coumarin moiety. These latter complexes are used as catalyst photoinitiators in an oxidative cycle in combination with a silane and an iodonium salt. Remarkably, even under the selected very soft irradiations (e.g. light intensity lower than 2 mW/cm²), excellent polymerization profiles are obtained (conversions > 80%). The mechanisms are investigated by ESR and luminescence experiments.     

Spreadsheet applications in benefit/cost analysis

Benefit/Cost Analysis traditionally includes analysis of the financial ramifications of an expenditure along with some look at how sensitive the selected alternative is to changes in the critical variables. Non-tangibles are costs or benefits, typically benefits, which cannot easily be measured in dollar terms. This paper discusses an approach to benefit/cost analysis and a variety of tools which can be implemented in Lotus 17ndash;2–3 for use in teaching the concepts of benefits/cost analysis.     

Group treatment with divorced women using cognitive-behavioral and supportive-insight methods.

Examined the effectiveness of cognitive-behavioral and supportive-insight group therapy with 46 women (aged 23–36 yrs) who had been divorced between 8 mo and 1? yrs. 12 clients were assigned to the cognitive-behavioral group; 12 were assigned to a supportive-insight group; and 22 Ss were assigned to 2 control groups. Differences between pre- and posttest, and pretest and follow-up scores on measures of depression (Beck Depression Inventory, Lubin Depression Checklist), self-esteem (Rosenberg Self-Esteem Inventory), and neuroticism (Eysenck Personality Inventory) were taken. When compared with the control groups on the posttest, both cognitive-behavioral and supportive-insight treatments were more effective on most criteria. At the 4-mo follow-up, cognitive-behavioral counseling continued to be beneficial, whereas the supportive-insight approach was consistently less effective. (34 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)