The residential gateway

Burgeoning competition in telecommunications is multiplying the number of communications paths into the home-but a standard multinetwork connection could sort them out. Services going into the residence may enter over copper wires, hybrid fiber coax, RF transmission, fiber to the curb, or, most importantly, by any combination of these sources and structures. To have a successful market, residential customers must be able to move smoothly from one combination of these offerings to another so that the customers consider the move worthwhile. For this multinetwork-to-multiservice interconnection to have value, it must be simple, and that simplicity is the basis for the residential gateway concept. In other words, the substantial complexity of the interconnection must be hidden from the consumer. The concept is essentially the development of a set of interface standards between the broadband residential access networks and the communication services (the internal networks) required for the consumer's home     

Analysis of Sequence Divergence in Mammalian ABCGs Predicts a Structural Network of Residues That Underlies Functional Divergence

The five members of the mammalian G subfamily of ATP-binding cassette transporters differ greatly in their substrate specificity. Four members of the subfamily are important in lipid transport and the wide substrate specificity of one of the members, ABCG2, is of significance due to its role in multidrug resistance. To explore the origin of substrate selectivity in members 1, 2, 4, 5 and 8 of this subfamily, we have analysed the differences in conservation between members in a multiple sequence alignment of ABCG sequences from mammals. Mapping sets of residues with similar patterns of conservation onto the resolved 3D structure of ABCG2 reveals possible explanations for differences in function, via a connected network of residues from the cytoplasmic to transmembrane domains. In ABCG2, this network of residues may confer extra conformational flexibility, enabling it to transport a wider array of substrates.     

Long-term effects of behavior therapy: A 12-month follow-up.

19 female undergraduates who underwent various behavioral treatments designed to reduce a specific fear were paid to return for follow-up 1 yr. later. In general, treated Ss' rat fears were less intense 1 yr. after treatment than they had been prior to treatment, with those treated by systematic desensitization slightly less fearful than those treated with "rational therapy." Subsequently, the desensitized Ss eliminated a snake fear by themselves, but the effects of this self-administered desensitization were not maintained. Additionally, 6 children treated by operant conditioning techniques for various problems were reevaluated 1 yr. later. All behavior change was maintained, but only those who had graduated to social reinforcement showed additional improvement. No evidence for symptom substitution was obtained from either group of Ss. (PsycINFO Database Record (c) 2010 APA, all rights reserved)