A new deep convolutional neural network model for classifying breast cancer histopathological images and the hyperparameter optimisation of the proposed model

The Journal of Supercomputing - Deep learning algorithms have yielded remarkable results in medical diagnosis and image analysis, besides their contribution to improvements in a number of fields...     

Migration behavior of landfill leachate contaminants through alternative composite liners

Four identical pilot-scale landfill reactors with different alternative composite liners were simultaneously operated for a period of about 540 days to investigate and to simulate the migration behaviors of phenolic compounds (phenol, 2-CP, 2-MP, 3-MP, 4-MP, 2-NP, 4-NP, 2,4-DNP, 2,4-DCP, 2,6-DCP, 2,4,5-TCP, 2,4,6-TCP, 2,3,4,6-TeCP, PCP) and heavy metals (Pb, Cu, Zn, Cr, Cd, Ni) from landfill leachate to the groundwater. Alternative landfill liners of four reactors consist of R1: Compacted clay liner (10 cm + 10 cm, k = 10⁻⁸ m/sn), R2: Geomembrane (2 mm HDPE) + compacted clay liner (10 cm + 10 cm, k = 10⁻⁸ m/sn), R3: Geomembrane (2 mm HDPE) + compacted clay liner (10 cm, k = 10⁻⁸ m/sn) + bentonite liner (2 cm) + compacted clay liner (10 cm, k = 10⁻⁸ m/sn), and R4: Geomembrane (2 mm HDPE) + compacted clay liner (10 cm, k = 10⁻⁸ m/sn) + zeolite liner (2 cm) + compacted clay liner (10 cm, k = 10⁻⁸ m/sn). Wastes representing Istanbul municipal solid wastes were disposed in the reactors. To represent bioreactor landfills, reactors were operated by leachate recirculation. To monitor and control anaerobic degradation in the reactors, variations of conventional parameters (pH, alkalinity, chloride, conductivity, COD, TOC, TKN, ammonia and alcaly metals) were also investigated in landfill leachate samples. The results of this study showed that about 35-50% of migration of organic contaminants (phenolic compounds) and 55-100% of migration of inorganic contaminants (heavy metals) to the model groundwater could be effectively reduced with the use of bentonite and zeolite materials in landfill liner systems. Although leachate contaminants can reach to the groundwater in trace concentrations, findings of this study concluded that the release of these compounds from landfill leachate to the groundwater may potentially be of an important environmental concern based on the experimental findings.     

Chip geometry and cutting force prediction in gear hobbing

This paper presents a tri-dexel geometric engine integrated simulation model for the gear hobbing operation. The process kinematics are modeled and validated using CNC signals from a Liebherr LC500 hobbing machine. Workpiece geometry updating and cutter-workpiece engagement (CWE) calculations are efficiently realized in the tri-dexel engine. 3D force contributions at discretized nodes along the hob's cutting edges are computed considering the localized principal cutting directions, and rake and inclination angles. To measure cutting forces, a rotary dynamometer is successfully adapted and used alongside a Kalman filter to compensate for structural dynamics. The predicted forces agree well with their experimental counterparts.     

A new strain hardening model for rate-dependent crystal plasticity

This paper presents a crystal plasticity based finite element analysis employing the new microstructure-based strain hardening model recently presented by Saimoto and Van Houtte (2011) [7] to simulate formability and texture evolution in the commercial aluminum alloy 5754. Simulations are performed to compare the predictive capability of the new hardening model against the common work hardening models using a rate-dependent plasticity formulation. The parameters in the numerical models are calibrated using the X-ray data published by Iadicola et al. (2008) [9] for the aluminum sheet alloy 5754. The predictions of the model for balanced biaxial tension and in-plane plane-strain tests are compared against experimental observations presented in Iadicola et al. (2008) [9]. It is concluded that the new model provides the best predictions of the large strain behavior of Aluminum sheet alloy 5754 subjected to various strain paths.     

Robust compensation of elastic deformations in ball screw drives

Elastic deformations occur in ball screw drives typically due to inertial forces, guideway friction, and cutting forces. This results in elongation and compression of the ball screw, which deteriorates the dynamic linear positioning accuracy. Closing the control loop with a linear encoder helps to alleviate this problem to a certain extent. However, linear scales cost significantly more than rotary encoders and their installation also brings about additional costs. This paper presents a new strategy for mitigating the detrimental effect of elastic deformations, in order to improve the translational accuracy of ball screw drives when only rotational feedback is available. A simple and physically intuitive model is developed, which is used to offset the position commands that are fed to the servo control law. Compensation is proposed using a closed-loop scheme, which is found to be robust against cutting forces, as well as variations in the table mass and guideway friction. These effects are detected as equivalent disturbances that cause an elastic deformation. The proposed closed-loop compensation strategy has been validated in machining and high-speed tracking experiments, as well as simulations, which demonstrate its effectiveness in terms of improving the ball screw drive’s final translational accuracy.     

Reduced myofibroblast differentiation on femtosecond laser treated 316LS stainless steel

In-stent restenosis is a common complication after stent surgery which leads to a dangerous wall narrowing of a blood vessel. Laser assisted patterning is one of the effective methods to modify the stent surface to control cell–surface interactions which play a major role in the restenosis. In this current study, 316LS stainless steel substrates are structured by focusing a femtosecond laser beam down to a spot size of 50 μm. By altering the laser induced spot density three distinct surfaces (low density (LD), medium density (MD) and high density (HD)) were prepared. While such surfaces are composed of primary microstructures, due to fast melting and re-solidification by ultra-short laser pulses, nanofeatures are also observed as secondary structures. Following a detailed surface characterization (chemical and physical properties of the surface), we used a well-established co-culture assay of human microvascular endothelial cells and human fibroblasts to check the cell compatibility of the prepared surfaces. The surfaces were analyzed in terms of cell adherence, proliferation, cell morphology and the differentiation of the fibroblast into the myofibroblast, which is a process indicating a general fibrotic shift within a certain tissue. It is observed that myofibroblast proliferation decreases significantly on laser treated samples in comparison to non-treated ones. On the other hand endothelial cell proliferation is not affected by the surface topography which is composed of micro- and nanostructures. Such surfaces may be used to modify stent surfaces for prevention or at least reduction of restenosis.     

Predictors of attitudinal and behavioral outcomes in mobile advertising: A field experiment

The study examines consumer responses to SMS-based mobile advertising campaigns using a field experiment with actual behavioral responses. Specifically, the effects of message characteristics (i.e., incentives and prior permission) and individual differences of message recipients (i.e., content involvement, prior experience with the mobile medium, and medium-fit perceptions) on the attitudinal and behavioral outcomes of such campaigns are investigated. Perceived intrusiveness of the message and attitude toward the campaign are conceptualized as key attitudinal reactions triggered by a mobile advertising message, which in turn influence the behavioral responses generated by the campaign. Findings suggest that, in comparison to permission and incentive, individual differences are stronger determinants of responses to mobile advertising campaigns. Additionally, intriguing insights with respect to the effectiveness of different types of incentives are provided.     

老空间的魅力新生 海牙某历史建筑改造

<正>该建筑坐落在海牙市中心,邻近海牙森林,矗立在Bezuidenhoutseweg大街——一条连接皇家宫殿Huisten Bosch和荷兰国会建筑Het Binnenhof的历史性轴线。这个具有强烈而独特风格的雄伟建筑始建于1917年,由当时的政府首席建筑师DanielE.C. Knuttel设计,为财政紧缩时期的外交部办公所用,1994年由Hans     

Interference‐aware convergecast scheduling in wireless sensor/actuator networks for active airflow control applications

Emerging wireless sensor/actuator network (WSAN) technology has the potential to enable semi‐autonomous airflow control to improve the aerodynamic performance of aircraft. In this paper, a WSAN comprising of multiple linear sensor clusters terminated by actuators is proposed for active airflow control with the objective of minimizing convergecast latency. Here, the convergecast delay is defined as the time required from the beginning of a sampling period to all all sensor's data of this sampling period is received by the actuator. The objective is achieved by minimizing the separation distance of concurrent data transmission so that the number of nodes sending data in the same time slot is maximized. The problem turns into a scheduling problem with a proper selection of interference separation. However, most existing work on the scheduling in linear networks use the minimum separation of two hops to avoid collisions. This paper examines the relationship between the hop separation, signal‐to‐noise ratio, and the latency to make a selection of interference separation. A new interference aware hybrid line scheduling (HLS) algorithm is proposed and its energy consumption is analyzed. Compared with other line scheduling policies, the analysis and simulation results show that, at moderately high node densities, the proposed HLS with carefully selected hop separation is able to reduce both the delay by up to 15% and the energy consumption somehow. Copyright © 2012 John Wiley & Sons, Ltd.