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1.
为改进模型对高寒地区融雪径流模拟不足的缺陷,将融雪模块耦合到传统 abcd 模型。利用 1980—2018 年
逐月实测的径流数据和通过 AnuSpline 方法插值的格网气象要素,驱动改进后的abcd 模型,分析三江源生态保护
措施实施前后(1980—1999 年和 2000—2018 年)黄河源区径流的动态变化,并量化关键气象因素与人类活动对
径流变化的影响程度,即相对贡献。结果表明:耦合融雪模块的 abcd-snow 模型完善了高寒地区水文过程的模拟,
提高对径流的模拟性能,在黄河源区表现出较好的适用性;整个研究时段黄河源区的实测径流呈不显著减少趋势
(?0.80?mm/a,p>0.05),但 2000 年前径流则呈现显著下降趋势(?4.12?mm/a,p<0.05),2000 年后径流则呈显著增加
趋势(3.16?mm/a,p<0.05);?归因分析表明气候变化是源区径流变化的主导因素。2000 年前,气候变化对径流减少
的相对贡献率为 62.8%,人类活动对径流的贡献为 37.2%;2000 年后,气候变化对径流增加的贡献率达到 120.0?%,
人类活动对径流的贡献为?20.0%。其中:降水的变化是决定径流变化主导因素;其他气候因素的相对贡献较小;
以人类活动为主的生态恢复可显著降低河川径流。本研究有助于理解气候变化和下垫面变化对黄河源区水资源
变化的系统驱动机理,并为流域水资源合理配置提供科学参考依据。 相似文献
2.
Corey R. Nelson Tyler Mrozowich Sean M. Park Simmone Dsouza Amy Henrickson Justin R. J. Vigar Hans-Joachim Wieden Raymond J. Owens Borries Demeler Trushar R. Patel 《International journal of molecular sciences》2021,22(1)
Rift Valley fever virus (RVFV) is a mosquito-transmitted virus from the Bunyaviridae family that causes high rates of mortality and morbidity in humans and ruminant animals. Previous studies indicated that DEAD-box helicase 17 (DDX17) restricts RVFV replication by recognizing two primary non-coding RNAs in the S-segment of the genome: the intergenic region (IGR) and 5′ non-coding region (NCR). However, we lack molecular insights into the direct binding of DDX17 with RVFV non-coding RNAs and information on the unwinding of both non-coding RNAs by DDX17. Therefore, we performed an extensive biophysical analysis of the DDX17 helicase domain (DDX17135–555) and RVFV non-coding RNAs, IGR and 5’ NCR. The homogeneity studies using analytical ultracentrifugation indicated that DDX17135–555, IGR, and 5’ NCR are pure. Next, we performed small-angle X-ray scattering (SAXS) experiments, which suggested that DDX17 and both RNAs are homogenous as well. SAXS analysis also demonstrated that DDX17 is globular to an extent, whereas the RNAs adopt an extended conformation in solution. Subsequently, microscale thermophoresis (MST) experiments were performed to investigate the direct binding of DDX17 to the non-coding RNAs. The MST experiments demonstrated that DDX17 binds with the IGR and 5’ NCR with a dissociation constant of 5.77 ± 0.15 µM and 9.85 ± 0.11 µM, respectively. As DDX17135–555 is an RNA helicase, we next determined if it could unwind IGR and NCR. We developed a helicase assay using MST and fluorescently-labeled oligos, which suggested DDX17135–555 can unwind both RNAs. Overall, our study provides direct evidence of DDX17135–555 interacting with and unwinding RVFV non-coding regions. 相似文献
3.
Chun Fah Mok Yern Chee Ching Noor Azuan Abu Osman Farina Muhamad Mohd Usman Mohd Junaidi Jia H. Choo 《应用聚合物科学杂志》2020,137(35):49044
In the quest on improving composite formulations for environmental sustainability, maleic acid (MA) cross-linked poly(vinyl alcohol) (PVA)-α-chitin composites reinforced by oil palm empty fruit bunch fibers (OPEFB)-derived nanocellulose crystals (NCC) had been successfully prepared. Based on the Fourier transform infrared (FTIR) spectroscopic analysis, it was proven that molecular interactions of the cross-linker to the polymeric networks was through conjugated ester linkage. Differential scanning calorimetry (DSC) showed that the influence of MA was minimal toward crystallization in the PVA/chitin/NCC composite. Maximum tensile strength, elongation at break and Young's modulus of the respective PVA/chitin/NCC composites were achieved at different content of MA, dependent on the PVA/chitin mass ratio. Among all compositions, a maximum Young's modulus was achieved at 30 wt% MA loading in PVA/chitin-30/NCC, amounting to 2,413.81 ± 167.36 MPa. Moreover, the mechanical properties and selected physicochemical properties (swelling, gel content, and contact angle) of the PVA/chitin/NCC composites could be tailored by varying the chitin content (10–30 wt%) and MA content (10–50 wt% based on total mass of composite). In brief, this chemically cross-linked PVA-based biocomposites formulated with sustainable resources exhibited tunable physicochemical and mechanical properties. 相似文献
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6.
Jonas Ahlstedt Thuy A. Tran Sven-Erik Strand Magnus Gram Bo ?kerstr?m 《International journal of molecular sciences》2015,16(12):30309-30320
Peptide receptor radionuclide therapy (PRRT) has been in clinical use for 15 years to treat metastatic neuroendocrine tumors. PRRT is limited by reabsorption and retention of the administered radiolabeled somatostatin analogues in the proximal tubule. Consequently, it is essential to develop and employ methods to protect the kidneys during PRRT. Today, infusion of positively charged amino acids is the standard method of kidney protection. Other methods, such as administration of amifostine, are still under evaluation and show promising results. α1-microglobulin (A1M) is a reductase and radical scavenging protein ubiquitously present in plasma and extravascular tissue. Human A1M has antioxidation properties and has been shown to prevent radiation-induced in vitro cell damage and protect non-irradiated surrounding cells. It has recently been shown in mice that exogenously infused A1M and the somatostatin analogue octreotide are co-localized in proximal tubules of the kidney after intravenous infusion. In this review we describe the current situation of kidney protection during PRRT, discuss the necessity and implications of more precise dosimetry and present A1M as a new, potential candidate for renal protection during PRRT and related targeted radionuclide therapies. 相似文献
7.
Klimis?S.?NtalianisEmail author Anastasios?D.?Doulamis Nikolaos?D.?Doulamis Nikos?E.?Mastorakis Athanasios?S.?Drigas 《Journal of Signal Processing Systems》2015,80(2):153-161
In this paper, we present a novel memory access reduction scheme (MARS) for two-dimension fast cosine transform (2-D FCT). It targets programmable DSPs with high memory-access latency. It reduces the number of memory accesses by: 1) reducing the number of weighting factors and 2) combining butterflies in vector-radix 2-D FCT pruning diagram from two stages to one stage with an efficient structure. Hardware platform based on general purpose processor is used to verify the effectiveness of the proposed method for vector-radix 2-D FCT pruning implementation. Experimental results validate the benefits of the proposed method with reduced memory access, less clock cycle and fewer memory space compared with the conventional implementation. 相似文献
8.
Ebbe Toftgaard Poulsen Agnete Larsen Alen Zollo Arne L. J?rgensen Kristian W. Sanggaard Jan J. Enghild Carmela Matrone 《International journal of molecular sciences》2015,16(12):29446-29453
The Amyloid Precursor Protein (APP) has been extensively studied for its role as the precursor of the β-amyloid protein (Aβ) in Alzheimer’s disease (AD). However, our understanding of the normal function of APP is still patchy. Emerging evidence indicates that a dysfunction in APP trafficking and degradation can be responsible for neuronal deficits and progressive degeneration in humans. We recently reported that the Y682 mutation in the 682YENPTY687 domain of APP affects its binding to specific adaptor proteins and leads to its anomalous trafficking, to defects in the autophagy machinery and to neuronal degeneration. In order to identify adaptors that influence APP function, we performed pull-down experiments followed by quantitative mass spectrometry (MS) on hippocampal tissue extracts of three month-old mice incubated with either the 682YENPTY687 peptide, its mutated form, 682GENPTY687 or its phosphorylated form, 682pYENPTY687. Our experiments resulted in the identification of two proteins involved in APP internalization and trafficking: Clathrin heavy chain (hc) and its Adaptor Protein 2 (AP-2). Overall our results consolidate and refine the importance of Y682 in APP normal functions from an animal model of premature aging and dementia. Additionally, they open the perspective to consider Clathrin hc and AP-2 as potential targets for the design and development of new therapeutic strategies. 相似文献
9.
The rainbow hologram provides views of reconstruction with rainbow color within a large viewing zone. In our recent paper, a Fourier rainbow holographic display using diffraction grating and a white‐light LED source was introduced. In this technique, the rainbow effect is realized by the dispersion of white‐light source on diffraction grating, while the slit is implemented numerically by reducing the demands of the space‐bandwidth product of the display. This paper presents a novel analysis on the visual perception of the Fourier rainbow holographic display using Wigner distribution. The view‐dependent appearance of the image, including multispectral field of view and viewing zone, is investigated considering the observer and the display parameters. The resolution of the holographic view is also investigated. For this, a new quantitative assessment for image blur is introduced using Wigner distribution analysis. The analysis is supported with numerical simulations and experimentally captured optical reconstructions for the holograms of the computer model and real object generated with different slit size, reconstruction distance, and different observation conditions. 相似文献
10.
Jinho Choi Sanghun Jung Deok Gun Park Jaegul Choo Niklas Elmqvist 《Computer Graphics Forum》2019,38(3):249-260
The majority of visualizations on the web are still stored as raster images, making them inaccessible to visually impaired users. We propose a deep‐neural‐network‐based approach that automatically recognizes key elements in a visualization, including a visualization type, graphical elements, labels, legends, and most importantly, the original data conveyed in the visualization. We leverage such extracted information to provide visually impaired people with the reading of the extracted information. Based on interviews with visually impaired users, we built a Google Chrome extension designed to work with screen reader software to automatically decode charts on a webpage using our pipeline. We compared the performance of the back‐end algorithm with existing methods and evaluated the utility using qualitative feedback from visually impaired users. 相似文献