Tooth instance segmentation from cone-beam CT images through point-based detection and Gaussian disentanglement

Multimedia Tools and Applications - Individual tooth segmentation and identification from cone-beam computed tomography images are preoperative prerequisites for orthodontic treatments. Instance...     

Detection Technique of Software-Induced Rowhammer Attacks

Side-channel attacks have recently progressed into software-induced attacks. In particular, a rowhammer attack, which exploits the characteristics of dynamic random access memory (DRAM), can quickly and continuously access the cells as the cell density of DRAM increases, thereby generating a disturbance error affecting the neighboring cells, resulting in bit flips. Although a rowhammer attack is a highly sophisticated attack in which disturbance errors are deliberately generated into data bits, it has been reported that it can be exploited on various platforms such as mobile devices, web browsers, and virtual machines. Furthermore, there have been studies on bypassing the defense measures of DRAM manufacturers and the like to respond to rowhammer attacks. A rowhammer attack can control user access and compromise the integrity of sensitive data with attacks such as a privilege escalation and an alteration of the encryption keys. In an attempt to mitigate a rowhammer attack, various hardware- and software-based mitigation techniques are being studied, but there are limitations in that the research methods do not detect the rowhammer attack in advance, causing overhead or degradation of the system performance. Therefore, in this study, a rowhammer attack detection technique is proposed by extracting common features of rowhammer attack files through a static analysis of rowhammer attack codes.     

Beneficial Effects of Melatonin Combined with Exercise on Endogenous Neural Stem/Progenitor Cells Proliferation after Spinal Cord Injury

Endogenous neural stem/progenitor cells (eNSPCs) proliferate and differentiate into neurons and glial cells after spinal cord injury (SCI). We have previously shown that melatonin (MT) plus exercise (Ex) had a synergistic effect on functional recovery after SCI. Thus, we hypothesized that combined therapy including melatonin and exercise might exert a beneficial effect on eNSPCs after SCI. Melatonin was administered twice a day and exercise was performed on a treadmill for 15 min, six days per week for 3 weeks after SCI. Immunohistochemistry and RT-PCR analysis were used to determine cell population for late response, in conjunction with histological examination and motor function test. There was marked improvement in hindlimb function in SCI+MT+Ex group at day 14 and 21 after injury, as documented by the reduced size of the spinal lesion and a higher density of dendritic spines and axons; such functional improvements were associated with increased numbers of BrdU-positive cells. Furthermore, MAP2 was increased in the injured thoracic segment, while GFAP was increased in the cervical segment, along with elevated numbers of BrdU-positive nestin-expressing eNSPCs in the SCI+MT+Ex group. The dendritic spine density was augmented markedly in SCI+MT and SCI+MT+Ex groups. These results suggest a synergistic effect of SCI+MT+Ex might create a microenvironment to facilitate proliferation of eNSPCs to effectively replace injured cells and to improve regeneration in SCI.     

On the volume power density of radial thermoelectric generators

We examine the volume power density of radial thermoelectric generators (TEGs). Radial, or tubular, TEGs have been considered as an alternative to the usual flat-plate TEGs due to its improved geometric match to typical curved heat sources and high surface power density. However, surface power density is not the only important performance index in realistic situations. Especially for TEGs with inorganic materials that have high raw material prices, volume power density can be important as well. In this note, an analytic model of a radial TEG is studied with a numerical trial-and-error approach for investigating its volume power density. At the same time, an alternative, approximate method of estimating the maximum power of the radial TEG is presented. Using these two approaches, we estimate the volume power density of a skutterudite-based radial TEG and compare the results to those of a flat-plate TEG. The volume power density of the radial TEG is significantly lower than that of the flat-plate TEG. For example, our calculation for a representative case with free convection on the cold side shows that the volume power density of the radial TEG will be 107 W/m³ at best. The result improves with forced convection, and our calculation for a representative case with forced convection on the cold side exhibits the maximum volume power density of 24 100 W/m³ . All these values turn out to be smaller roughly by one order of magnitude than the maximum volume power densities of comparable flat-plate TEGs. Such a low volume power density indicates lower economic feasibility of the radial TEG with expensive inorganic thermoelectric materials. This is also explicitly discussed by presenting the high cost per watt of the radial TEG. It is therefore suggested that radial TEGs with less expensive organic materials may be more acceptable than those with inorganic ones.     

Muscle stem cell isolation and in vitro culture for meat production: A methodological review

Cultured muscle tissue-based protein products, also known as cultured meat, are produced through in vitro myogenesis involving muscle stem cell culture and differentiation, and mature muscle cell processing for flavor and texture. This review focuses on the in vitro myogenesis for cultured meat production. The muscle stem cell–based in vitro muscle tissue production consists of a sequential process: (1) muscle sampling for stem cell collection, (2) muscle tissue dissociation and muscle stem cell isolation, (3) primary cell culture, (4) upscaled cell culture, (5) muscle differentiation and maturation, and (6) muscle tissue harvest. Although muscle stem cell research is a well-established field, the majority of these steps remain to be underoptimized to enable the in vitro creation of edible muscle-derived meat products. The profound understanding of the process would help not only cultured meat production but also business sectors that have been seeking new biomaterials for the food industry. In this review, we discuss comprehensively and in detail each step of cutting-edge methods for cultured meat production. This would be meaningful for both academia and industry to prepare for the new era of cellular agriculture.     

Brain‐Inspired Photonic Neuromorphic Devices using Photodynamic Amorphous Oxide Semiconductors and their Persistent Photoconductivity

The combination of a neuromorphic architecture and photonic computing may open up a new era for computational systems owing to the possibility of attaining high bandwidths and the low‐computation‐power requirements. Here, the demonstration of photonic neuromorphic devices based on amorphous oxide semiconductors (AOSs) that mimic major synaptic functions, such as short‐term memory/long‐term memory, spike‐timing‐dependent plasticity, and neural facilitation, is reported. The synaptic functions are successfully emulated using the inherent persistent photoconductivity (PPC) characteristic of AOSs. Systematic analysis of the dynamics of photogenerated carriers for various AOSs is carried out to understand the fundamental mechanisms underlying the photoinduced carrier‐generation and relaxation behaviors, and to search for a proper channel material for photonic neuromorphic devices. It is found that the activation energy for the neutralization of ionized oxygen vacancies has a significant influence on the photocarrier‐generation and time‐variant recovery behaviors of AOSs, affecting the PPC behavior.     

Latch Applicator for Efficient Delivery of Dissolving Microneedles Based on Rapid Release of Elastic Strain Energy by Thumb Force (Adv. Funct. Mater. 11/2023)

Dissolving microneedle (DMN) is an attractive alternative to parenteral and enteral drug administration owing to its painless self-administration and safety due to non-generation of medical waste. For reproducible and efficient DMN administration, various DMN application methods, such as weights, springs, and electromagnetic devices, have been studied. However, these applicators have complex structures that are complicated to use and high production costs. In this study, a latch applicator that consists of only simple plastic parts and operates via thumb force without any external complex device is developed. Protrusion-shaped latches and impact distances are designed to accumulate thumb force energy through elastic deformation and to control impact velocity. The optimized latch applicator with a pressing force of 25 N and an impact velocity of 5.9 m s⁻¹ fully inserts the drug-loaded tip of the two-layered DMN into the skin. In an ovalbumin immunization test, DMN with the latch applicator shows a significantly higher IgG antibody production rate than that of intramuscular injection. The latch applicator, which provides effective DMN insertion and a competitive price compared with conventional syringes, has great potential to improve delivery of drugs, including vaccines.     

Covalent 0D–2D Heterostructuring of Co9S8–MoS2 for Enhanced Hydrogen Evolution in All pH Electrolytes

Ultrasmall Co₉S₈ nanoparticles are introduced on the basal plane of MoS₂ to fabricate a covalent 0D–2D heterostructure that enhances the hydrogen evolution reaction (HER) activity of electrochemical water splitting. In the heterostructure, separate phases of Co₉S₈ and MoS₂ are formed, but they are connected by Co–S–Mo type covalent bonds. The charge redistribution from Co to Mo occurring at the interface enhances the electron‐doped characteristics of MoS₂ to generate electron‐rich Mo atoms. Besides, reductive annealing during the synthesis forms S defects that activates adjacent Mo atoms for further enhanced HER activity as elucidated by the density functional theory (DFT) calculation. Eventually, the covalent Co₉S₈–MoS₂ heterostructure shows amplified HER activity as well as stability in all pH electrolytes. The synergistic effect is pronounced when the heterostructure is coupled with a porous Ni foam (NF) support to form Co₉S₈–MoS₂/NF that displays superior performance to those of the state‐of‐the‐art non‐noble metal electrocatalysts, and even outperforms a commercial Pt/C catalyst in a practically meaningful, high current density region in alkaline (>170 mA cm^?2) and neutral (>60 mA cm^?2) media. The high HER performance and stability of Co₉S₈–MoS₂ heterostructure make it a promising pH universal alternative to expensive Pt‐based electrocatalysts for practical water electrolyzers.