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排序方式: 共有90条查询结果,搜索用时 15 毫秒
1.
Mulders Dounia de Bodt Cyril Bjelland Johannes Pentland Alex Verleysen Michel de Montjoye Yves-Alexandre 《Neural computing & applications》2020,32(24):18023-18043
Neural Computing and Applications - Social networks are known to be assortative with respect to many attributes, such as age, weight, wealth, level of education, ethnicity and gender: Similar... 相似文献
2.
Gavin Lawes Simon C. J. Kingsley Andrei Golov Norbert Mulders James V. Porto Jeevak M. Parpia 《Journal of Low Temperature Physics》2000,121(5-6):567-572
We have investigated the superfluid transition of
3
He in different samples of silica aerogel. Several of these samples have been characterized using x-ray imaging, yielding information about the microstructure of the aerogel. In comparing new measurements on a 99.5% sample with previous observations on the behavior of
3
He in 98% porous aerogel we have found evidence for a scaling of the superfluid transition temperature to the correlation length of the aerogel. Furthermore, the superfluid density exhibits a similar universal behaviour over a range of values of reduced temperature. We discuss these new results in the context of superfluid pairing in the presence of a correlated disorder, specifically focussing on the fractal nature of the aerogel. 相似文献
3.
EW Steyerberg HJ Keizer SD Foss? DT Sleijfer GC Toner H Schraffordt Koops PF Mulders JE Messemer K Ney JP Donohue 《Canadian Metallurgical Quarterly》1995,13(5):1177-1187
PURPOSE: To develop a statistical model that predicts the histology (necrosis, mature teratoma, or cancer) after chemotherapy for metastatic nonseminomatous germ cell tumor (NSGCT). PATIENTS AND METHODS: An international data set was collected comprising individual patient data from six study groups. Logistic regression analysis was used to estimate the probability of necrosis and the ratio of cancer and mature teratoma. RESULTS: Of 556 patients, 250 (45%) had necrosis at resection, 236 (42%) had mature teratoma, and 70 (13%) had cancer. Predictors of necrosis were the absence of teratoma elements in the primary tumor, prechemotherapy normal alfa-fetoprotein (AFP), normal human chorionic gonadotropin (HCG), and elevated lactate dehydrogenase (LDH) levels, a small prechemotherapy or postchemotherapy mass, and a large shrinkage of the mass during chemotherapy. Multivariate combination of predictors yielded reliable models (goodness-of-fit tests, P > .20), which discriminated necrosis well from other histologies (area under the receiver operating characteristic (ROC) curve, .84), but which discriminated cancer only reasonably from mature teratoma (area, .66). Internal and external validation confirmed these findings. CONCLUSION: The validated models estimate with high accuracy the histology at resection, especially necrosis, based on well-known and readily available predictors. The predicted probabilities may help to choose between immediate resection of a residual mass or follow-up, taking into account the expected benefits and risks of resection, feasibility of frequent follow-up, the financial costs, and the patient's individual preferences. 相似文献
4.
R. T. Azuah H. R. Glyde R. Scherm N. Mulders B. Fåk 《Journal of Low Temperature Physics》2003,130(5-6):557-567
We present neutron scattering measurements of Bose-Einstein condensation (BEC) in liquid 4He confined in Vycor. The data show clear evidence of a condensate in Vycor with a condensate fraction comparable to that of bulk superfluid 4He, approximately 7.5% at low temperature and SVP. The temperature dependence of n0(T) is also similar to that in the bulk with critical temperature for BEC, TBEC, in the range 1.80BEC<2.05 K. The data are not accurate enough to show whether TBEC for Vycor is the same or greater than the depressed critical temperature for superfluidity, Tc=1.95 K. 相似文献
5.
TM Mulders Keizer J Ouwerkerk EA van der Velde DD Breimer GJ Mulder 《Canadian Metallurgical Quarterly》1995,1(12):1525-1536
Several studies have suggested that the glutathione/glutathione S-transferase (GSH/GST) system is involved in resistance of tumors toward ifosfamide and other cytostatic agents. Besides, ifosfamide metabolites (in vitro) as well as ifosfamide treatment (in vivo) have been shown to decrease cellular GSH availability. In the present study, the in vivo effects of three different ifosfamide treatment schedules on the GSH/GST system were studied in patients with advanced cancers (n = 24): continuous i.v. infusions of 1300 mg/m2 daily for 10 days and 5000 mg/m2/day for 24 h, as well as a 4-h infusion of 3000 mg/m2 daily for 3 days. The GSH/GST system was characterized by administering bromisoval, a probe drug to assess GSH conjugation activity in vivo, as well as by daily monitoring of GSH concentrations in blood cells and plasma. Bromisoval pharmacokinetics was assessed before and at the end of the ifosfamide treatment. Blood cell GSH levels decreased significantly (P < 0.05) during the 3- and 10-day ifosfamide treatment schedules; the 24-h treatment had no effect. The ifosfamide treatment schedules had only minimal effects on bromisoval pharmacokinetics. Assuming that the kinetics of the probe drug provide an accurate reflection of enzyme activity, this suggests that GST activity remains unchanged. Because GSH conjugation of bromisoval enantiomers requires both GST activity and GSH availability, these results also indicate that, despite the 35% decrease in GSH in blood cells of two patient groups, the GSH availability of the cancer patients was not rate-limiting for GSH conjugation of bromisoval enantiomers. If GSH levels in blood cells reflect those in tumors/other tissues, the present results indicate that ifosfamide may be used clinically to decrease GSH levels. However, whether a 35% decrease is sufficient to increase tumor sensitivity toward (other) cytostatics remains uncertain. 相似文献
6.
V. V. Dmitriev D. A. Krasnikhin N. Mulders D. E. Zmeev 《Journal of Low Temperature Physics》2008,150(3-4):493-498
We have found a new stable spin state in the A-like phase of superfluid 3He confined to intrinsically anisotropic aerogel. The state can be formed by radiofrequency excitation applied while cooling
through the superfluid transition temperature and its NMR properties are different from the standard A-like phase obtained
in the limit of very small excitation. It is possible that this new state is formed by textural domain walls pinned by aerogel.
相似文献
7.
A Veldman G J Borggreve E J Mulders D van de Lagemaat 《Food Additives & Contaminants》1992,9(6):647-655
The mycotoxin contamination of feed components used by the Dutch cooperative feed industry was surveyed to estimate the risk for animal production losses. Of 89 randomly and 6 selectively taken samples of raw materials harvested in 1988 and 1989 27% were contaminated with ochratoxin A (OCHRA), 31% with zearalenone (ZEA) and 20% with deoxynivalenol (DON). The mean content (microgram/kg) of all positive randomly taken samples was 18 (OCHRA), 62 (ZEA) and 630 (DON). The highest level (microgram/kg) for all samples was 120 (OCHRA) in barley, 3100 (ZEA) in corn cob mix and 1900 (DON) in maizegluten feed. The results of this survey show that feed components are often contaminated with mycotoxins. However, the contamination level could only sporadically cause production losses in animal husbandry. 相似文献
8.
9.
E. J. Mulders J. H. Dhont 《Zeitschrift für Lebensmitteluntersuchung und -Forschung A》1972,150(4):228-232
Summary Carbonyl compounds of white bread, isolated by extraction, were identified as their 2,4-dinitrophenylhydrazones by thin-layer chromatography. Acids were separated from an extract of white bread as their sodium salts, regenerated and analysed by gas chromatography. 24 carbonyl compounds and 13 acids were identified. Of these, 9 carbonyl compounds and 8 acids had not been previously reported to occur in the aroma of white bread.
Die II. Mitteilung erscheint in Heft 5 (Anm. d. Red.) 相似文献
Zusammenfassung Carbonylverbindungen von Weißbrot sind — nach Isolierung durch Extraktion — mittels Dünnschichtchromatographie als 2,4-Dinitrophenylhydrazone identifiziert worden. Sduren werden als Natriumsalze von einem Weißbrotextrakt abgetrennt und gaschro matographisch analysiert. 24 Carbonylverbindungen und 13 Säuren wurden identifiziert, wovon 9 Carbonylverbindungen und 8 Säuren in der einschlägigen Literatur noch nicht erwähnt worden sind.
Die II. Mitteilung erscheint in Heft 5 (Anm. d. Red.) 相似文献
10.
TM Mulders DJ Bergman BT Poll-The GP Smit DD Breimer GJ Mulder M Duran JA Smeitink 《Canadian Metallurgical Quarterly》1997,20(4):473-485
Previous studies have suggested that tyrosinaemia type I may be associated with reduced glutathione availability due to conjugation of tyrosinaemia-associated reactive intermediates with glutathione. In the present study, the glutathione/ glutathione S-transferase system of two tyrosinaemia patients and three healthy controls were characterized by administering the racemic sedative drug bromisoval, a probe drug for assessing glutathione conjugation activity in vivo. Furthermore, concentrations of glutathione and glutathione S-transferase class alpha (GSTA) isoenzymes as well as the glutathione S-transferase class mu phenotype were assessed in the blood of six tyrosinaemia patients. The excretion of bromisoval mercapturates in healthy children was comparable to that observed in healthy adults. Tyrosinaemia patients were found to have a very high urinary recovery of bromisoval mercapturates (> or = 60% of the dose compared to about 30% for healthy, age-matched children and adults), which could be attributed mainly to a higher urinary excretion of the mercapturate derived from S-bromisoval. Healthy children and adults predominantly excrete the (R)-bromisoval mercapturate. The differences in amount excreted as well as in stereoselectivity of the urinary excretion of bromisoval mercapturates in tyrosinaemia patients are possibly related to an increased activity of specific glutathione S-transferase isoenzymes. Plasma glutathione and blood cell glutathione disulphide concentrations in tyrosinaemia patients were normal. Low blood cell glutathione concentrations were in general found only in two patients with a poor clinical condition. These results indicate that, in contrast to previous suggestions, reduced glutathione availability is not a generalized problem in (stabilized) tyrosinaemia patients. 相似文献