The Sandia Fracture Challenge: blind round robin predictions of ductile tearing

Existing and emerging methods in computational mechanics are rarely validated against problems with an unknown outcome. For this reason, Sandia National Laboratories, in partnership with US National Science Foundation and Naval Surface Warfare Center Carderock Division, launched a computational challenge in mid-summer, 2012. Researchers and engineers were invited to predict crack initiation and propagation in a simple but novel geometry fabricated from a common off-the-shelf commercial engineering alloy. The goal of this international Sandia Fracture Challenge was to benchmark the capabilities for the prediction of deformation and damage evolution associated with ductile tearing in structural metals, including physics models, computational methods, and numerical implementations currently available in the computational fracture community. Thirteen teams participated, reporting blind predictions for the outcome of the Challenge. The simulations and experiments were performed independently and kept confidential. The methods for fracture prediction taken by the thirteen teams ranged from very simple engineering calculations to complicated multiscale simulations. The wide variation in modeling results showed a striking lack of consistency across research groups in addressing problems of ductile fracture. While some methods were more successful than others, it is clear that the problem of ductile fracture prediction continues to be challenging. Specific areas of deficiency have been identified through this effort. Also, the effort has underscored the need for additional blind prediction-based assessments.     

Compression stress–strain and creep properties of the 52In–48Sn and 97In–3Ag low-temperature Pb-free solders

Lead (Pb)-free, low melting temperature solders are required for step-soldering processes used to assemble micro-electrical mechanical system (MEMS) and optoelectronic (OE) devices. Stress–strain and creep studies, which provide solder mechanical properties for unified creep-plasticity (UCP) predictive models, were performed on the Pb-free 97In–3Ag (wt.%) and 58In–42Sn solders and counterpart Pb-bearing 80In–15Pb–5Ag and 70In–15Sn–9.6Pb–5.4Cd alloys. Stress–strain tests were performed at 4.4 × 10^?5 s^?1 and 8.8 × 10^?4 s^?1. Stress–strain and creep tests were performed at ?25, 25, 75, and 100°C or 125°C. The samples were evaluated in the as-fabricated and post-annealed conditions. The In–Ag solder had yield stress values of 0.5–8.5 MPa. The values of ΔH for steady-state creep were 99 ± 14 kJ/mol and 46 ± 11 kJ/mol, indicating that bulk diffusion controlled creep in the as-fabricated samples (former) and fast-diffusion controlled creep in the annealed samples (latter). The In–Sn yield stresses were 1.0–22 MPa and were not dependent on an annealed condition. The steady-state creep ΔH values were 55 ± 11 kJ/mol and 48 ± 13 kJ/mol for the as-fabricated and annealed samples, respectively, indicating the fast-diffusion controlled creep for the two conditions. The UCP constitutive models were derived for the In–Ag solder in the as-fabricated and annealed conditions.     

Transforming growth factor-beta enhances the ultraviolet-mediated stress response in p53-/- keratinocytes

This review focuses on the contributions of modern mass spectrometry to neuropeptide research. An introduction to newer mass spectrometric techniques is provided. Also, the use of mass spectrometry in combination with high-resolution separation techniques for neuropeptide identification in biological samples is illustrated. The amino acid sequence information that is important for the identification and analysis of known, novel, or chemically modified neuropeptides may be obtained using mass spectrometric techniques. Because mass spectrometry techniques can be used to reflect the dynamic properties associated with neuropeptide processing in biological systems, they may be used in the future to monitor peptide profiles within organisms in response to environmental challenges such as disease and stress.     

Cell proliferation,viability, and in vitro differentiation of equine mesenchymal stem cells seeded on bacterial cellulose hydrogel scaffolds

The culture of multipotent mesenchymal stem cells on natural biopolymers holds great promise for treatments of connective tissue disorders such as osteoarthritis. The safety and performance of such therapies relies on the systematic in vitro evaluation of the developed stem cell-biomaterial constructs prior to in vivo implantation. This study evaluates bacterial cellulose (BC), a biocompatible natural polymer, as a scaffold for equine-derived bone marrow mesenchymal stem cells (EqMSCs) for application in bone and cartilage tissue engineering. An equine model was chosen due to similarities in size, load and types of joint injuries suffered by horses and humans. Lyophilized and critical point dried BC hydrogel scaffolds were characterized using scanning electron microscopy (SEM) to confirm nanostructure morphology which demonstrated that critical point drying induces fibre bundling unlike lyophilisation. EqMSCs positively expressed the undifferentiated pluripotent mesenchymal stem cell surface markers CD44 and CD90. The BC scaffolds were shown to be cytocompatible, supporting cellular adhesion and proliferation, and allowed for osteogenic and chondrogenic differentiation of EqMSCs. The cells seeded on the BC hydrogel were shown to be viable and metabolically active. These findings demonstrate that the combination of a BC hydrogel and EqMSCs are promising constructs for musculoskeletal tissue engineering applications.     

Coarsening of the Sn-Pb solder microstructure in constitutive model-based predictions of solder joint thermal mechanical fatigue

An expression for the coarsening rate of the Pb-rich phase particles was determined through isothermal aging experiments and comparative literature data as:

Coterie join algorithm

Given a set of nodes in a distributed system, a coterie is a collection of subsets of the set of nodes such that any two subsets have a nonempty intersection and are not properly contained in one another. A subset of nodes in a coterie is called a quorum. An algorithm, called the join algorithm, which takes nonempty coteries as input, and returns a new, larger coterie called a composite coterie is introduced. It is proved that a composite coterie is nondominated if and only if the input coteries are nondominated. Using the algorithm, dominated or nondominated coteries may be easily constructed for a large number of nodes. An efficient method for determining whether a given set of nodes contains a quorum of a composite coterie is presented. As an example, tree coteries are generalized using the join algorithm, and it is proved that tree coteries are nondominated. It is shown that the join algorithm may be used to generate read and write quorums which may be used by a replica control protocol     

A GIS-based modeling approach for implementation of sustainable farm management practices

Few agricultural producers utilize the true analytical power of GIS and computer simulation models, partly because the loose linkages developed to-date between GIS and most public-domain modeling software are extremely cumbersome to use. The integrated system (EPIC–View) developed in the study allows the integration of a comprehensive hydrologic–crop management model (EPIC) with a desktop GIS to function as a planning tool aimed at implementing sustainable farm management practices. The use of GIS makes possible the integration of diverse spatial data into a comprehensive spatial database. EPIC–View is applied to simulate nitrogen (N) dynamics under conventional and minimum tillage conditions of a field located in Caddo County, Oklahoma. In general, the overall N balance obtained under minimum tillage is better than the balance obtained under conventional tillage over a 5-year model run. Unexplained losses of N averaged 9.55% and 4.2% of the gain in N under conventional and minimum tillage respectively. The integrated modeling system holds immense potential as a farm management tool. Various components of a sustainable agricultural system including irrigation management, crop management, soil management, and pest management, can be efficiently managed. This approach could make farms more economically viable and ecologically sound.     

Application of a new stress finite element to analysis of shell structures

A new stress finite element for analysis of shell structures of arbitrary geometry and loading has been introduced in Ref. [1]. The purpose of the present paper is to demonstrate the versatility of the proposed element with respect to all kinds of shell structures.