A Parallelization Approach for Hard Real-Time Systems and Its Application on Two Industrial Programs

Applications in industry often have grown and improved over many years. Since their performance demands increase, they also need to benefit from the availability of multi-core processors. However, a reimplementation from scratch and even a restructuring of these industrial applications is very expensive, often due to high certification efforts. Therefore, a strategy for a systematic parallelization of legacy code is needed. We present a parallelization approach for hard real-time systems, which ensures a high reusage of legacy code and preserves timing analysability. To show its applicability, we apply it on the core algorithm of an avionics application as well as on the control program of a large construction machine. We create models of the legacy programs showing the potential of parallelism, optimize them and change the source codes accordingly. The parallelized applications are placed on a predictable multi-core processor with up to 18 cores. For evaluation, we compare the worst case execution times and their speedups. Furthermore, we analyse limitations coming up at the parallelization process.     

TCMI: a non-parametric mutual-dependence estimator for multivariate continuous distributions

Data Mining and Knowledge Discovery - The identification of relevant features, i.e., the driving variables that determine a process or the properties of a system, is an essential part of the...     

Drug solubility in fatty acids as a formulation design approach for lipid-based formulations: a technical note

Lipid-based drug delivery systems have been intensively investigated as a means of delivering poorly water-soluble drugs. Upon ingestion, the lipases in the gastrointestinal tract digest lipid ingredients, mainly triglycerides, within the formulation into monoglycerides and fatty acids. While numerous studies have addressed the solubility of drugs in triglycerides, comparatively few publications have addressed the solubility of drugs in fatty acids, which are the end product of digestion and responsible for the solubility of drug within mixed micelles. The objective of this investigation was to explore the solubility of a poorly water-soluble drug in fatty acids and raise the awareness of the importance of drug solubility in fatty acids. The model API (active pharmaceutical ingredient), a weak acid, is considered a BCS II compound with an aqueous solubility of 0.02?μg/mL and predicted partition coefficient >7. The solubility of API ranged from 120?mg/mL to over 1?g/mL in fatty acids with chain lengths across the range C18 to C6. Hydrogen bonding was found to be the main driver of the solubilization of API in fatty acids. The solubility of API was significantly reduced by water uptake in caprylic acid but not in oleic acid. This report demonstrates that solubility data generated in fatty acids can provide an indication of the solubility of the drug after lipid digestion. This report also highlights the importance of measuring the solubility of drugs in fatty acids in the course of lipid formulation development.