全文获取类型
收费全文 | 2723篇 |
免费 | 176篇 |
国内免费 | 3篇 |
专业分类
电工技术 | 23篇 |
综合类 | 1篇 |
化学工业 | 608篇 |
金属工艺 | 58篇 |
机械仪表 | 66篇 |
建筑科学 | 63篇 |
矿业工程 | 3篇 |
能源动力 | 122篇 |
轻工业 | 368篇 |
水利工程 | 14篇 |
石油天然气 | 22篇 |
无线电 | 260篇 |
一般工业技术 | 444篇 |
冶金工业 | 427篇 |
原子能技术 | 37篇 |
自动化技术 | 386篇 |
出版年
2024年 | 9篇 |
2023年 | 27篇 |
2022年 | 37篇 |
2021年 | 109篇 |
2020年 | 83篇 |
2019年 | 100篇 |
2018年 | 89篇 |
2017年 | 93篇 |
2016年 | 97篇 |
2015年 | 79篇 |
2014年 | 84篇 |
2013年 | 164篇 |
2012年 | 136篇 |
2011年 | 169篇 |
2010年 | 110篇 |
2009年 | 131篇 |
2008年 | 129篇 |
2007年 | 95篇 |
2006年 | 96篇 |
2005年 | 96篇 |
2004年 | 78篇 |
2003年 | 47篇 |
2002年 | 41篇 |
2001年 | 42篇 |
2000年 | 42篇 |
1999年 | 41篇 |
1998年 | 121篇 |
1997年 | 85篇 |
1996年 | 60篇 |
1995年 | 47篇 |
1994年 | 30篇 |
1993年 | 42篇 |
1992年 | 17篇 |
1991年 | 23篇 |
1990年 | 14篇 |
1989年 | 14篇 |
1988年 | 17篇 |
1987年 | 16篇 |
1986年 | 11篇 |
1985年 | 19篇 |
1984年 | 7篇 |
1983年 | 13篇 |
1982年 | 9篇 |
1981年 | 13篇 |
1980年 | 10篇 |
1979年 | 9篇 |
1978年 | 15篇 |
1977年 | 16篇 |
1976年 | 21篇 |
1973年 | 7篇 |
排序方式: 共有2902条查询结果,搜索用时 46 毫秒
1.
Dr. Jelena Melesina Conrad V. Simoben Lucas Praetorius Emre F. Bülbül Dr. Dina Robaa Prof. Dr. Wolfgang Sippl 《ChemMedChem》2021,16(9):1336-1359
This review classifies drug-design strategies successfully implemented in the development of histone deacetylase (HDAC) inhibitors, which have many applications including cancer treatment. Our focus is on especially demanded selective HDAC inhibitors and their structure-activity relationships in relation to corresponding protein structures. The main part of the paper is divided into six subsections each narrating how optimization of one of six structural features can influence inhibitor selectivity. It starts with the impact of the zinc binding group on selectivity, continues with the optimization of the linker placed in the substrate binding tunnel as well as the adjustment of the cap group interacting with the surface of the protein, and ends with the addition of groups targeting class-specific sub-pockets: the side-pocket-, lower-pocket- and foot-pocket-targeting groups. The review is rounded off with a conclusion and an outlook on the future of HDAC inhibitor design. 相似文献
2.
3.
4.
5.
Giorgio Benedek Joseph R. Manson Salvador Miret-Artés 《Advanced materials (Deerfield Beach, Fla.)》2020,32(25):2002072
Atom scattering is becoming recognized as a sensitive probe of the electron–phonon interaction parameter λ at metal and metal-overlayer surfaces. Here, the theory is developed, linking λ to the thermal attenuation of atom scattering spectra (in particular, the Debye–Waller factor), to conducting materials of different dimensions, from quasi-1D systems such as W(110):H(1 × 1) and Bi(114), to quasi-2D layered chalcogenides, and high-dimensional surfaces such as quasicrystalline 2ML-Ba(0001)/Cu(001) and d-AlNiCo(00001). Values of λ obtained using He atoms compare favorably with known values for the bulk materials. The corresponding analysis indicates in addition, the number of layers contributing to the electron–phonon interaction, which is measured in an atom surface collision. 相似文献
6.
Polyana Alves Radi Angela Vieira Lucas Manfroi Karina Carvalho de Farias Nass Marco Antonio Ramirez Ramos Priscila Leite Gislene Valdete Martins Jorge Benedito Freire Jofre Lucia Vieira 《Ceramics International》2019,45(7):9686-9693
There has been a recent increase in both the production and consumption of ethanol due to the numerous environmental advantages that it offers, such as the fact that it can be produced from a variety of renewable materials, for instance corn and cellulose, or it can be obtained from sugarcane bagasse and biomass (2nd and 3rd generation ethanol). The result of this is that nowadays ethanol is widely seen as the dominant biofuel – or as a blend component in gasoline or pure fuel - in many countries.However, one disadvantage of the use of ethanol is the high corrosive behavior that occurs when its hygroscopic properties are exposed to a large number of materials. Xiaoyuan Lou and Preet Singh showed that the increase of water concentration in ethanol induces pitting and metal loss. Diamond-Like Carbon (DLC) films may be a solution to this problem due to the fact that they can be deposited inside tubes, offer good protection levels against corrosion, and reduce the friction coefficient and wear.This paper shows the tribocorrosion and corrosion studies of DLC films deposited on stainless steel grade 304 (SS304) substrates in order to gauge its appropriateness usage in the construction of pipelines and fuel storage tanks. The surface morphology was analyzed before and after 14 days of immersion. The tribocorrosion, friction coefficient, and wear rate were studied in ethanol to see the effects of water concentration. The films showed good adherence to the substrates. Corrosion and tribocorrosion results showed that for bare Stainless Steel 304 the increase of the water content increases the corrosion and the friction coefficient. DLC coated samples presented few points of delamination, and the friction coefficient and open circuit potentials were very low compared with the bare sample which was water concentration independent. 相似文献
7.
Dr. Monica Varese Dr. Salvador Guardiola Dr. Jesús García Prof. Ernest Giralt 《Chembiochem : a European journal of chemical biology》2019,20(24):2981-2986
Our laboratory has recently identified two nanobodies (small antibodies produced by camelids)—Nb1 and Nb6—that bind efficiently to epithelial growth factor (EGF) and inhibit its ability to activate its receptor (EGFR). Because of the relevance of the EGF/EGFR axis as a target in oncology, these new nanobodies have promising therapeutic potential. This article, however, is focused on another feature of these nanobodies: their distinct thermodynamic signatures. Nb1 binds to EGF through an entropy-driven mechanism whereas Nb6 binds to this factor under enthalpic control. We discuss the advantages and disadvantages of each mechanism in the contexts of traditional medical chemistry (small-molecule drugs) and also of biological drugs. In this latter case, the implications in terms of selectivity are far from being clearly established and further experimental data are required. Their monomeric natures, high stability, and ease of recombinant production make nanobodies ideally suited for thermodynamic studies. Moreover, nanobodies, thanks to their simpler structures in comparison with conventional antibodies, might provide better understanding of the structural basis of the thermodynamic parameters of antigen recognition. 相似文献
8.
Deborah Oliveira De Fusco Leonardo Lucas Madaleno Vanildo Luiz Del Bianchi Aline da Silva Bernardo Rafael Roberto Assis Gustavo Henrique de Almeida Teixeira 《International Journal of Food Science & Technology》2019,54(7):2416-2424
Alcohol-free beer with isotonic properties is getting more popular and its production can be carried out by different production strategies; however, interrupted fermentation is still a challenge. Therefore, the objective of this study was to develop a low-alcohol isotonic beer (<0.5% v/v) by interrupted fermentation. Moreover, the major objective is to compare the developed product to commercial beverages (sports drinks, ‘Pilsen' regular beer, alcohol-free beers and low-alcohol isotonic beer). The beverages were evaluated based on pH, alcohol content (% v/v), total titratable acidity (mEq L−1), osmolality (mOsmol kg−1), bitterness International Bitterness Units, colour European Brewery Convention, total phenolic compounds (mg L−1 gallic acid), reducing and total sugars (%) and Na and K contents (mg L−1). The developed low-alcohol isotonic beer presented characteristics similar to sports drinks, with the advantage of being richer in phenolic compounds and suitable osmolality. Despite salts were added in its formulation, the grades attributed to all beers employed in the sensory evaluation, as well as the purchase intention did not present significant differences. 相似文献
9.
10.
Matheus Henrique Jantsch Viviane Martins Bernardes Juliana Sorraila Oliveira Daniela Ferreira Passos Guilherme Lopes Dornelles Alessandra Guedes Manzoni Fernanda Licker Cabral Jean Lucas Gutknecht da Silva Maria Rosa Chitolina Schetinger Daniela Bitencourt Rosa Leal 《Journal of Food Biochemistry》2021,45(4):e13636