药物相互作用研究在新药研发和审评决策中的应用

药物相互作用改变了剂量效应关系，可能会降低疗效或增加毒性，是临床应用中合并用药治疗时重要的考虑因素。预测具有临床意义的药物相互作用是药物研发过程中获益风险评估的重要环节。本文概述了药物研发过程中药物相互作用研究的目的和意义，体内和体外研究的主要内容；梳理分析了2020年国家药品监督管理局（National Medical Products Administration, NMPA）和美国食品药品监督管理局（Food and Drug Administration, FDA）批准上市的新药药物相互作用研究情况，旨在为我国药物研发过程中药物相互作用研究及其监管审评提供参考。     

建立福州市、县级行政区域界线信息管理系统的探讨

结合福州市行政区域界线勘查工作已结束的实际和社会信息化发展的趋势，提出建立该市市、县级行政区域界线信息管理系统的重要性，对该系统的基本框架、实施方案、建立步骤及与“数字福建”接轨等问题进行了初步讨论，提出了建议。     

内部质量审核的方法与技巧

本文概述了内部质量审核的概念、方法和技巧。在质量管理实践中结合本单位实际着重对内部质量审核方法和审核技巧进行系统阐述     

Norman Joseph Slamecka (1928-2003).

Presents an obituary for Norman J. Slamecka (1928-2003). Slamecka and his wife Jan were killed suddenly in a pedestrian accident on August 2, 2003, in Lewes, Delaware. He was a Marine veteran of the Korean War, and after a few years of practice as a clinical psychologist for the Veterans Administration, he accepted a faculty position at the University of Vermont in Burlington. He then taught at the State University of New York at Buffalo for a short while before coming to the University of Toronto in 1970, where he remained until his retirement in 1994. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

论港口危险货物运输装卸作业安全问题

危险货物作业安全越来越受到人们的关注，从危险货物的分类谈起，分析了危险货物港口运输装卸作业中易引发事故的诸因素和安全作业中应特别注意的几个问题，强调从业单位、从业人员的资质、法律意识和业务素质，制定危险货物事故应急预案等。提出了加强港口危险货物安全管理的有关建议：开展危险源与事故隐患的多层次监控；推进港航危险货物企业建立安全质量标准化体系；创建“抓小放大”的安全管理机制。     

积极引导新社会阶层有序参政议政的思考

改革开放30年来中国社会结构发生的最大变化是新社会阶层的形成。随着社会主义市场经济体制的初步建立,新社会阶层的队伍不断壮大,使中国经济、社会的影响力也越来越大,并在政治舞台上渐渐有了一席之地。人们参政愿望的强烈、自身素质的提高以及参政过程中存在的不同程度的问题,为新社会阶层有序参政提供了可能性和必要性,而执政党的积极引导则成为新社会阶层有序参政议政的领路航标。     

为官不为:界定、根源及治理

"为官不为"可以分为能力缺失型、享乐散漫型、环绕推挡型、名利偏好型、被动应激型和闻风观望型. 管理体制、行政机制、传统文化等方面存在的某些不良因子促成了为官不为现象."为官不为"的实质是公务员的主体性缺位. 治理"为官不为"现象必须强化公务员的个体素质,优化行政机制,正确理解传统文化,实现综合治理.     

行政管理学研究性教学方法探析

目前越来越多的高校开始尝试实行研究性教学。与传统的教学方法相比,研究性教学更能体现m学生在教学活动中的主体地位,更能充分地发挥学生学习的积极性和主动性。根据行政管理学的学科特点,结合研究性教学的具体环节,提出行政管理学研究性教学方法,包括专题讨论、辩论、讲座、角色转换、案例讨论等方法。     

教务管理系统的研究与设计

根据目前高等院校的教务管理的业务流程,对教务管理系统进行了相关的研究和设计,分析了系统采用Browser/Server(B/S)模式的优点,分析和研究了教务管理业务的相关流程,并在此基础上设计了系统总体架构、系统功能结构,并根据系统数据库的ER模型,对数据库和数据表进行了分析与设计.     

Hands-free administration of subjective workload scales: Acceptability in a surgical training environment

Introduction

Subjective workload measures are usually administered in a visual-manual format, either electronically or by paper and pencil. However, vocal responses to spoken queries may sometimes be preferable, for example when experimental manipulations require continuous manual responding or when participants have certain sensory/motor impairments. In the present study, we evaluated the acceptability of the hands-free administration of two subjective workload questionnaires - the NASA Task Load Index (NASA-TLX) and the Multiple Resources Questionnaire (MRQ) - in a surgical training environment where manual responding is often constrained.

Method

Sixty-four undergraduates performed fifteen 90-s trials of laparoscopic training tasks (five replications of 3 tasks - cannulation, ring transfer, and rope manipulation). Half of the participants provided workload ratings using a traditional paper-and-pencil version of the NASA-TLX and MRQ; the remainder used a vocal (hands-free) version of the questionnaires. A follow-up experiment extended the evaluation of the hands-free version to actual medical students in a Minimally Invasive Surgery (MIS) training facility.

Results

The NASA-TLX was scored in 2 ways - (1) the traditional procedure using participant-specific weights to combine its 6 subscales, and (2) a simplified procedure - the NASA Raw Task Load Index (NASA-RTLX) - using the unweighted mean of the subscale scores. Comparison of the scores obtained from the hands-free and written administration conditions yielded coefficients of equivalence of r = 0.85 (NASA-TLX) and r = 0.81 (NASA-RTLX). Equivalence estimates for the individual subscales ranged from r = 0.78 (“mental demand”) to r = 0.31 (“effort”). Both administration formats and scoring methods were equally sensitive to task and repetition effects. For the MRQ, the coefficient of equivalence for the hands-free and written versions was r = 0.96 when tested on undergraduates. However, the sensitivity of the hands-free MRQ to task demands (η_partial² = 0.138) was substantially less than that for the written version (η_partial² = 0.252). This potential shortcoming of the hands-free MRQ did not seem to generalize to medical students who showed robust task effects when using the hands-free MRQ (η_partial² = 0.396). A detailed analysis of the MRQ subscales also revealed differences that may be attributable to a “spillover” effect in which participants’ judgments about the demands of completing the questionnaires contaminated their judgments about the primary surgical training tasks.

Conclusion

Vocal versions of the NASA-TLX are acceptable alternatives to standard written formats when researchers wish to obtain global workload estimates. However, care should be used when interpreting the individual subscales if the object is to make comparisons between studies or conditions that use different administration modalities. For the MRQ, the vocal version was less sensitive to experimental manipulations than its written counterpart; however, when medical students rather than undergraduates used the vocal version, the instrument’s sensitivity increased well beyond that obtained with any other combination of administration modality and instrument in this study. Thus, the vocal version of the MRQ may be an acceptable workload assessment technique for selected populations, and it may even be a suitable substitute for the NASA-TLX.