In vivo Kinetic Biodistribution of Nano‐Sized Outer Membrane Vesicles Derived from Bacteria

Evaluation of kinetic distribution and behaviors of nanoparticles in vivo provides crucial clues into their roles in living organisms. Extracellular vesicles are evolutionary conserved nanoparticles, known to play important biological functions in intercellular, inter‐species, and inter‐kingdom communication. In this study, the first kinetic analysis of the biodistribution of outer membrane vesicles (OMVs)—bacterial extracellular vesicles—with immune‐modulatory functions is performed. OMVs, injected intraperitoneally, spread to the whole mouse body and accumulate in the liver, lung, spleen, and kidney within 3 h of administration. As an early systemic inflammation response, increased levels of TNF‐α and IL‐6 are observed in serum and bronchoalveolar lavage fluid. In addition, the number of leukocytes and platelets in the blood is decreased. OMVs and cytokine concentrations, as well as body temperature are gradually decreased 6 h after OMV injection, in concomitance with the formation of eye exudates, and of an increase in ICAM‐1 levels in the lung. Following OMV elimination, most of the inflammatory signs are reverted, 12 h post‐injection. However, leukocytes in bronchoalveolar lavage fluid are increased as a late reaction. Taken together, these results suggest that OMVs are effective mediators of long distance communication in vivo.     

浅析火力发电厂汽水系统中内径管与外径管的设计选择

按照管道加工工艺的不同,管道可分为内径控制管和外径控制管。通过热轧工艺生产的外径控制无缝钢管,可满足火力发电厂汽水系统中绝大部分管道的使用要求。对于超(超)临界机组的主蒸汽和高温再热蒸汽管道采用的P91/P92材质的大口径厚壁无缝钢管,由于对材料性能和加工工艺有特殊要求,因此宜采用内径控制管。     

基于主体外部轮廓的照片分割算法

在实际应用中常常需要将人像从照片的背景中有效地分割出来，通常的做法是通过提取照片中人像各部分特征来实现分割，其缺陷是计算复杂度较大，分割效果受各种干扰因素影响很大。现提出了一种基于主体外部轮廓信息的照片分割算法，通过梯度锐化、边缘保护、临近像素点相似度比较来确定图像的边界，该算法对于具有相对均匀背景的照片具有较高的计算效率。     

Microwave Communication to Moving Parts Inside Machines

Cables to moving parts on a linear actuator in production machines, such as pick-and-place machines, are a source of unreliability owing to the possible breaking of a cable. They further reduce the positioning precision of the actuator owing to additional forces. Slotted waveguide systems for rail vehicles based on 2.4 GHz transmission frequency are well known, but transmitters/receivers and waveguides are bulky. The paper reports on the reduction in size of the equipment, adapted to 5.8 GHz using a commercial off-the-shelf RadioLan communication module. Further, the efficient termination of the wave-guide and a new way to reduce standing-wave effects is also discussed.     

浅析2020年前美军事战略重点的转变--从装备发展看美国军事战略重点可能的变化

美国21世纪前期的军事战略重点将是争夺外空优势，夺取制天权和制信息权。分析了美国夺取外空优势的原因，及其为夺取外空优势在国家政策、航天发展和技术准备等方面采取的措施。     

立井钢丝绳罐道的特点及使用

介绍了钢丝绳罐道的特点,从《煤矿安全规程》的要求出发,考虑钢丝绳罐道的形式、 刚度、定位张紧、布置方式、钢丝绳数目等因素,分析了钢丝绳罐道的选择要点,并指出了钢丝绳罐 道的使用和维护方法。     

万家寨大坝外部变形控制网综述

结合万家寨水利枢纽大坝外部变形控制网测量项目 ,从控制网的布设、标点建造、观测、数据处理及成果分析等方面进行了介绍。实际观测结果说明 ,该控制网能够准确反映大坝运行状态 ,满足工程安全运行需要     

用φ76 mm穿孔机组生产φ63mm毛管的设备改进

介绍了用Φ76mm穿孔机组生产Φ63mm毛管的设备概况及其改进。改进后，Φ76mm穿孔机组增加了产品范围为后面的冷技工序减少了拉拔道次，从而降低了Φ51mm以下冷拔管的生产成本。     

中国先进研究堆导流箱流场的数值模拟

采用目前国内普遍使用的计算流体力学 (CFD)软件PHOENICS 3 2对中国先进研究堆不同结构的导流箱的三维流场进行数值模拟计算。结果表明 :导流箱入口导流板和导流筒能显著改善导流箱入口冷却剂的流动状况 ,获得入口冷却剂沿周向均匀分流的效果 ,达到显著减缓入口冷却剂对垂直辐照孔道导管及安全棒导管直接的横向水力冲刷的设计目的