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Risk management is becoming increasingly important for railway companies in order to safeguard their passengers and employees while improving safety and reducing maintenance costs. However, in many circumstances, the application of probabilistic risk analysis tools may not give satisfactory results because the risk data are incomplete or there is a high level of uncertainty involved in the risk data. This article presents the development of a risk management system for railway risk analysis using fuzzy reasoning approach and fuzzy analytical hierarchy decision making process. In the system, fuzzy reasoning approach (FRA) is employed to estimate the risk level of each hazardous event in terms of failure frequency, consequence severity and consequence probability. This allows imprecision or approximate information in the risk analysis process. Fuzzy analytical hierarchy process (fuzzy-AHP) technique is then incorporated into the risk model to use its advantage in determining the relative importance of the risk contributions so that the risk assessment can be progressed from hazardous event level to hazard group level and finally to railway system level. This risk assessment system can evaluate both qualitative and quantitative risk data and information associated with a railway system effectively and efficiently, which will provide railway risk analysts, managers and engineers with a method and tool to improve their safety management of railway systems and set safety standards. A case study on risk assessment of shunting at Hammersmith depot is used to illustrate the application of the proposed risk assessment system. 相似文献
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Daniel J. O’Shannessy Stephen M. Jackson Natalie C. Twine Bryan E. Hoffman Zoltan Dezso Sergei I. Agoulnik Elizabeth B. Somers 《International journal of molecular sciences》2013,14(7):13687-13703
Folate receptor alpha (FOLR1/FRA) is reported to be overexpressed in epithelial ovarian cancers (EOC), especially the serous histotype. Further, while dysregulation of the folate-dependent 1-carbon cycle has been implicated in tumorogenesis, little is known relative to the potential mechanism of action of FOLR1 expression in these processes. We therefore investigated the expression of FOLR1, other folate receptors, and genes within the 1-carbon cycle in samples of EOC, normal ovary and fallopian tube on a custom TaqMan Low Density Array. Also included on this array were known markers of EOC such as MSLN, MUC16 and HE4. While few differences were observed in the expression profiles of genes in the 1-carbon cycle, genes previously considered to be overexpressed in EOC (e.g., FOLR1, MSLN, MUC16 and HE4) showed significantly increased expression when comparing EOC to normal ovary. However, when the comparator was changed to normal fallopian tube, these differences were abolished, supporting the hypothesis that EOC derives from fallopian fimbriae and, further, that markers previously considered to be upregulated or overexpressed in EOC are most likely not of ovarian origin, but fallopian in derivation. Our findings therefore support the hypothesis that the cell of origin of EOC is tubal epithelium. 相似文献
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新型增益平坦光纤喇曼放大器的研究 总被引:5,自引:1,他引:4
利用光子转换理论的前向受激喇曼散射(SRS)耦合方程,结合多波长泵浦和光纤级联两种方法,提出了一种新型的具有平坦增益的宽带光纤喇曼放大器(FRA).采用数值解法对100信道的波分复用(WDM)系统进行了仿真,得到了宽带增益平坦的功率输出,为光纤喇曼放大器(FRA)增益平坦化提供了一种新的实现方法. 相似文献
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