Dendrimer as nanocarrier for drug delivery

Dendrimers are novel three dimensional, hyperbranched globular nanopolymeric architectures. Attractive features like nanoscopic size, narrow polydispersity index, excellent control over molecular structure, availability of multiple functional groups at the periphery and cavities in the interior distinguish them amongst the available polymers. Applications of dendrimers in a large variety of fields have been explored. Drug delivery scientists are especially enthusiastic about possible utility of dendrimers as drug delivery tool. Terminal functionalities provide a platform for conjugation of the drug and targeting moieties. In addition, these peripheral functional groups can be employed to tailor-make the properties of dendrimers, enhancing their versatility. The present review highlights the contribution of dendrimers in the field of nanotechnology with intent to aid the researchers in exploring dendrimers in the field of drug delivery.     

基于故障树与键合图的贝叶斯网络故障诊断

基于模型的故障诊断往往采用人工智能技术来处理不确定的知识和不完整的信息。概率推理法是一种处理不确定或不完整信息的方法,而贝叶斯网络是一种能够将它应用于实际的工具。提出了一种基于故障树和键合图理论来构建贝叶斯网络模型的新方法,并对系统进行故障诊断。实现了对引起系统或过程的异常行为的元件进行准确定位,并获得同时出现故障的元件对系统影响程度的大小,即为系统操作员提供了一个关于系统组件的优先级检查和维护计划。最后,对此方法的性能进行了仿真验证。