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Dendrimer as nanocarrier for drug delivery
Authors:Prashant Kesharwani  Keerti Jain  Narendra Kumar Jain
Affiliation:Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Central University, Sagar (MP) 470 003, India
Abstract:Dendrimers are novel three dimensional, hyperbranched globular nanopolymeric architectures. Attractive features like nanoscopic size, narrow polydispersity index, excellent control over molecular structure, availability of multiple functional groups at the periphery and cavities in the interior distinguish them amongst the available polymers. Applications of dendrimers in a large variety of fields have been explored. Drug delivery scientists are especially enthusiastic about possible utility of dendrimers as drug delivery tool. Terminal functionalities provide a platform for conjugation of the drug and targeting moieties. In addition, these peripheral functional groups can be employed to tailor-make the properties of dendrimers, enhancing their versatility. The present review highlights the contribution of dendrimers in the field of nanotechnology with intent to aid the researchers in exploring dendrimers in the field of drug delivery.
Keywords:AFM  atomic force microscopy  BHA  benzhydrylamine  BSA  bovine serum albumin  CE  capillary electrophoresis  CNTs  carbon nanotubes  CPDs  cationic phosphorus-containing dendrimers  CZE  capillary zone electrophoresis  DMPC  1  2-dimyristoyl-sn-glycero-3-phosphocholine  DOX  doxorubicin  DPA  2  4-dichlorophenoxyacetic acid  DSC  differential scanning calorimetry  DTPA  diethylene triamine pentaacetic acid  EDTA  ethylenediamine tetraacetic acid  ESI  electrospray ionization  ESI-MS  electrospray ionization-mass spectrometry  FA  folic acid  FAB-MS  fast-atom bombardment-mass spectrometry  FITC  fluorescein isothiocynate  FRET  fluorescence resonance energy transfer  FT-ICR MS  fourier transform ion cyclotron resonance mass spectrometry  FT-IR  fourier transform infrared spectroscopy  GFP  green fluorescence protein  GOx  glucose oxidase  Hb  hemoglobin  HCT  haematocrit  HEPES  (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid)  HPLC  high performance liquid chromatography  HRP  horseradish peroxide  HSV  herpes simplex virus  LC  liquid crystalline  LDH  lactate dehydrogenase  MALDI-TOF MS  matrix assisted laser desorption ionization-time of flight mass spectrometry  MAP  multiple antigen peptides  MPEG  methoxy polyethylene glycol  MRI  magnetic resonance imaging  MS  mass spectrometry  MTD  maximum tolerated dose  MTX  methotrexate  NMR  nuclear magnetic resonances  NSAIDs  non steroidal anti-inflammatory drugs  OS  organosilicon  PAGE  polyacrylamide gel electrophoresis  PAMAM  polyamidoamine  PAMAMOS  PAMAM-organosilicon dendrimers  PAMAM-SAHs  PAMAM succinamic acid dendrimers  PEI  polyethylenimine  PPI  poly (propylene imine)  PSMA  prostate-specific membrane antigen  PTX  paclitaxel  PVP  polyvinyl-pyrrolidone  RES  reticuloendothelial system  RNase  ribonuclease  RST  repetitive synthesis technique  SANS  small-angle neutron scattering  SAXS  small-angle X-ray scattering  SEC  size exclusion chromatography  siRNA  small interfering RNA  TEER  transepithelial electrical resistance  TEM  transmission electron microscopy  TGA  thermogravimetric analysis  TLR4  Toll-like receptor 4  UPLC  ultra performance liquid chromatography  WBCs  white blood corpuscles  XRD  X-ray diffraction
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