造血干细胞移植治疗外周T细胞淋巴瘤的进展

The general chemotherapy for Peripheral T-cell lymphoma (PTCL) featuring an active invasion has less curative effect and worse prognosis in comparison with that for B-cell non-Hodgkin's lymphoma (NHL). Studies in recent years suggest that hematopoietic stem cell transplantation (HSCT) has better curative effect on the PTCL; however, it is significant to do more studies on some aspects such as the methodology, punctuality, preconditioning, and pretreatment intensity of the transplantation, which are crucial to the curative effect.     

氯磺酚偶氮硫代若丹宁光度法测定微量金

研究了在CTMAB存在下,Au(Ⅲ)与氯磺酚偶氮硫代若丹宁的显色反应,实验表明,在pH = 3.0的盐酸溶液中,Au(Ⅲ)与试剂形成1:2的橘黄色络合物,其λmax = 460 nm,( = 1.52×105 L·mol-1·cm-1.Au(Ⅲ)含量在0～14 (g/10mL符合比尔定律.本法用于金矿石中微量金的测定,结果满意.     

Role of Toll-Like Receptor Signaling in the Pathogenesis of Graft-versus-Host Diseases

Graft-versus-host disease (GVHD) and infection are major complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and the leading causes of morbidity and mortality in HSCT patients. Recent work has demonstrated that the two complications are interdependent. GVHD occurs when allo-reactive donor T lymphocytes are activated by major histocompatibility antigens or minor histocompatibility antigens on host antigen-presenting cells (APCs), with the eventual attack of recipient tissues or organs. Activation of APCs is important for the priming of GVHD and is mediated by innate immune signaling pathways. Current evidence indicates that intestinal microbes and innate pattern-recognition receptors (PRRs) on host APCs, including both Toll-like receptors (TLRs) and nucleotide oligomerization domain (NOD)-like receptors (NLRs), are involved in the pathogenesis of GVHD. Patients undergoing chemotherapy and/or total body irradiation before allo-HSCT are susceptible to aggravated gastrointestinal epithelial cell damage and the subsequent translocation of bacterial components, followed by the release of endogenous dangerous molecules, termed pathogen-associated molecular patterns (PAMPs), which then activate the PRRs on host APCs to trigger local or systemic inflammatory responses that modulate T cell allo-reactivity against host tissues, which is equivalent to GVHD. In other words, infection can, to some extent, accelerate the progression of GVHD. Therefore, the intestinal flora’s PAMPs can interact with TLRs to activate and mature APCs, subsequently activate donor T cells with the release of pro-inflammatory cytokines, and eventually, induce GVHD. In the present article, we summarize the current perspectives on the understanding of different TLR signaling pathways and their involvement in the occurrence of GVHD.     

基于CDM模型的软硬件协同设计与实现

针对CDM模型和传统软硬件设计方法的不足，提出了实现软硬件协同设计与验证的HSCT平台：由多层抽象模型组成，以基于C＋＋的系统硬件语言SystemC作为单一的语言工具，分层细化，达到软硬件同步设计和验证的目的，提高了设计的效率和可靠性。     

氯磺酚偶氮硫代若丹宁固相萃取光度法测定水中的银

研究了氯磺酚偶氮硫代若丹宁 (HSCT)与银的显色反应。在pH 3.5的柠檬酸 -氢氧化钠缓冲介质中 ,HSCT与银反应生成 2∶1稳定络合物 ;该络合物可被C18固相小柱定量萃取 ,小柱上保留的络合物用DMF洗脱后用分光光度法测定 ;λmax =5 45nm ,体系ε =7.81× 1 0 4 L/ (mol·cm) ,银质量浓度在 0～ 1 .5mg/L内符合比尔定律。该方法可用于水样中痕量银的测定。