Tribology-optimised silk protein hydrogels for articular cartilage repair |
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| Affiliation: | 1. Research Center for Advanced Biomechanics, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan;2. Department of Applied Science for Integrated System Engineering, Graduate School of Engineering, Kyushu Institute of Technology, Japan;3. Department of Mechanical Engineering, Kyushu University, Japan;4. Department of Materials Science & Research Institute of Environment and Information Sciences, Yokohama National University, Japan;1. Syracuse Biomaterials Institute, Syracuse University, Syracuse, NY 13244, USA;2. Department of Mechanical & Aerospace Engineering, Syracuse University, Syracuse, NY 13244, USA;3. Department of Biomedical & Chemical Engineering, Syracuse University, Syracuse, NY 13244, USA |
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| Abstract: | Porous hydrogels were made from silk fibre as potential materials for cartilage repair. The aim was to develop materials which mimicked the tribological behaviour of cartilage, with controlled pore-sizes and optimised mechanical properties. Mechanical tests showed hydrogels had a comparable compressive modulus to cartilage, with stiffness improved by decreasing pore size. Under static loading and during shear hydrogels demonstrated significant interstitial fluid support. Friction testing showed the hydrogels had a cartilage-like frictional response, dominated by this interstitial fluid support. Silk hydrogels showed little wear, early signs of which were changes in surface morphology that did not correlate with the equilibrium friction coefficient. Consequently both wear and friction should be monitored when assessing the tribological performance of hydrogels. |
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| Keywords: | Articular cartilage Friction Biomaterial Hydrogel |
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