新型负载印楝素纳米粒子水分散液制备

目的]发展一种环境友好和具有缓释性能的印楝素水分散制剂。方法]以天然高分子壳聚糖(CS)和羧甲基壳聚糖(CMC)为载体,通过正负电荷的相互作用,制备了负载印楝素纳米粒子水分散液。表征了载药纳米粒子的性能如粒径、多分散指数(PDI)、Zeta电位值、负载率和形态结构,考察了几种影响性能的因素。结果]负载印楝素的纳米粒子为球形,尺寸为200～350 nm,PDI约为0.500,药物负载率最高可达55%。结论]CMC和CS合适的溶液质量浓度和用量是形成纳米子的基本条件。当其固定时,随印楝素质量浓度增加,载药粒子的粒径增大,PDI变宽,负载率降低。

Preparation of A Novel Azadirachtin Loaded Nanoparticle Aqueous Dispersion

A novel azadirachtin(Aza) loaded nanoparticle aqueous dispersion with environmentally friendly and sustained-release performances was developed.Methods] It was prepared by using a natural biodegradable polysaccharide chitosan(CS) and its derivative carboxymethyl chitosan(CMC) as the matrix materials,through the interaction between positive charge and negative charge.Properties of Aza loaded nanoparticle such as particle size,polydispersity index(PDI),Zeta potential,loading efficiency(LE) as well as morphology had been characterized.And the influence factors on properties of Aza loaded nanoparticle had been investigated.Results] The results showed that Aza loaded nanoparticles were spherical and had particle size between 200 and 350 nm,PDI of about 0.500 and LE up to 55%.Conclusions] The appropriate concentrations and their amounts were the basic condition to form nanoparticle.When they were fixed,the nanoparticle size increased,PDI broadened and LE decreased with the increasing Aza concentration.