五倍子抗菌微胶囊的制备及其结构探究

以海藻酸钠、壳聚糖为壁材,对采用锐孔造粒法制备五倍子抗菌微胶囊的工艺进行研究。通过单因素试验和正交试验,以包覆率、成形效果为主要评价指标,系统探讨制备五倍子抗菌微胶囊的最优工艺配置,结果表明:当氯化钙质量分数为4.0%、海藻酸钠质量分数为1.5%、壳聚糖质量分数为0.1%、海藻酸钠与五倍子提取物的投料质量比为3.5︰1.0时,所得五倍子抗菌微胶囊的包覆率高达(80.16±1.02)%,且外形良好、孔洞较多,为后续微胶囊抗菌性的深入探究奠定了基础。

Preparation and structure research of gallnut antibacterial microcapsules

The preparation technology using orifice granulation methods of gallnut antibacterial mi-crocapsule with sodium alginate and chitosan as wall materials was studied.Using cladding rate and forming effect as main evaluation indexes, the optimum process condition for preparation of the gall-nut antibacterial microcapsule was systematically discussed with single factor experiment and orthog-onal experiment.And the results showed that when calcium chloride was at 4.0%wt.,sodium algi-nate was at 1.5%wt., chitosan was at 0.1%wt., sodium alginate and gallnut drug weight ratio was at 3.5∶1.0, gallnut antibacterial microcapsule’ s encapsulation efficiency could reach (80.16 ± 1.02)%, and it had good appearance and more holes,which laid a foundation for subsequent study on antibacterial property of microcapsule.