| 微波合成阿司匹林的研究 |
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| 引用本文： | 张龙贵,曾胜强,丁婷,谢艳波,钟建芳.微波合成阿司匹林的研究[J].精细化工中间体,2009,39(5):44-46. |
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| 作者姓名： | 张龙贵 曾胜强 丁婷 谢艳波 钟建芳 |
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| 作者单位： | 长沙医学院药学系,湖南,长沙,410219 |
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| 基金项目： | 湖南省教厅资助大学生研究性实验项目 |
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| 摘 要： | 以硫酸镍为催化剂，水杨酸和醋酐为原料用微波法合成阿司匹林。考察了催化剂用量、原料配比、辐射功率、辐射时间等因素对收率的影响。合成工艺条件为：n（水杨酸）：n（醋酐）：n（硫酸镍）=1：2：0．1，微波辐射时间为50S，辐射功率为480W，收率达87．7％。该合成工艺简单，产品质量好且污染少。
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| 关 键 词： | 合成 微波 硫酸镍 阿司匹林 |
Study on the Microwave-assisted Synthesis of Aspirin Catalyzed by Nickel Sulfate |
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| ZHANG Long-gui,ZENG Sheng-qiang,DING Ting,XIE Yan-bo,ZHONG Jian-fang.Study on the Microwave-assisted Synthesis of Aspirin Catalyzed by Nickel Sulfate[J].Fine Chemical Intermediates,2009,39(5):44-46. |
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| Authors: | ZHANG Long-gui ZENG Sheng-qiang DING Ting XIE Yan-bo ZHONG Jian-fang |
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| Affiliation: | (Department of Pharmacy, Changsha Medical University, Changsha410219, China) |
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| Abstract: | With nickel sulfate as catalyst, the synthesis of aspirin from salicylic acid and acetic anhydride with by means of microwave radiation was studied. The affecting factors on the yield were investigated. The target product was obtained in 87.7% yield under the conditions of the molar ratio of salicylic acid to acetic anhydride and nickel sulfate of 1∶2.0∶0.1, radiation time of 50 s, and microwave power of 480 W. |
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| Keywords: | synthesis microwave nickel sulfate aspirin |
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